Clinical application of ceramics in anterior cervical discectomy and fusion: A review and update

Study Design: Narrative review. Objectives: Anterior cervical discectomy and fusion (ACDF) is a reliable procedure, commonly used for cervical degenerative disc disease. For interbody fusions, autograft was the gold standard for decades; however, limited availability and donor site morbidities have led to a constant search for new materials. Clinically, it has been shown that calcium phosphate ceramics, including hydroxyapatite (HA) and tricalcium phosphate (TCP), are effective as osteoconductive materials and bone grafts. In this review, we present the current findings regarding the use of ceramics in ACDF. Methods: A review of the relevant literature examining the clinical use of ceramics in anterior cervical discectomy and fusion procedures was conducted using PubMed, OVID and Cochrane. Result: HA, coralline HA, sandwiched HA, TCP, and biphasic calcium phosphate ceramics were used in combination with osteoinductive materials such as bone marrow aspirate and various cages composed of poly-ether-ether-ketone (PEEK), fiber carbon, and titanium. Stand-alone ceramic spacers have been associated with fracture and cracks. Metallic cages such as titanium endure the risk of subsidence and migration. PEEK cages in combination with ceramics were shown to be a suitable substitute for autograft. Conclusion: None of the discussed options has demonstrated clear superiority over others, although direct comparisons are often difficult due to discrepancies in data collection and study methodologies. Future randomized clinical trials are warranted before definitive conclusions can be drawn. © The Author(s) 2017

Nonclassical correlation in a multipartite quantum system: two measures and evaluation

There is a commonly recognized paradigm in which a multipartite quantum system described by a density matrix having no product eigenbasis is considered to possess nonclassical correlation. Supporting this paradigm, we define two entropic measures of nonclassical correlation of a multipartite quantum system. One is defined as the minimum uncertainty about a joint system after we collect outcomes of particular local measurements. The other is defined by taking the maximum over all local systems about the minimum distance between a genuine set and a mimic set of eigenvalues of a reduced density matrix of a local system. The latter measure is based on an artificial game to create mimic eigenvalues of a reduced density matrix of a local system from eigenvalues of a density matrix of a global system. Numerical computation of these measures for several examples is performed.Comment: v1: 10 pages, 8 figures, IOPART, v2: introduction modified, figure 7 replaced, v3: 10 pages, 10 figures, RevTeX4, major revision with an additional measure introduced, title changed (previous title: Non-classical correlation in a multi-partite quantum system reconsidered), to appear in Phys. Rev.

Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy

Adhesion to extracellular matrix (ECM) is crucially important for survival of normal epithelial cells as detachment from ECM triggers specific apoptosis known as anoikis. As tumor cells lose the requirement for anchorage to ECM, they rely on cell-cell adhesion 'multicellular aggregation' for survival. Multicellular aggregation of tumor cells also significantly determines the sensitivity of tumor cells to the cytotoxic effects of chemotherapeutics. In this report, we demonstrate that expression of immunoglobulin containing and proline-rich receptor-1 (IGPR-1) is upregulated in human primary colon cancer. Our study demonstrates that IGPR-1 promotes tumor multicellular aggregation, and interfering with its adhesive function inhibits multicellular aggregation and, increases cell death. IGPR-1 supports colon carcinoma tumor xenograft growth in mouse, and inhibiting its activity by shRNA or blocking antibody inhibits tumor growth. More importantly, IGPR-1 regulates sensitivity of tumor cells to the chemotherapeutic agent, doxorubicin/adriamycin by a mechanism that involves doxorubicin-induced AKT activation and phosphorylation of IGPR-1 at Ser220. Our findings offer novel insight into IGPR-1's role in colorectal tumor growth, tumor chemosensitivity, and as a possible novel anti-cancer target.Grant support from: R01 CA175382/CA/NCI NIH HHS/United States, R21 CA191970/CA/NCI NIH HHS/United States, and R21 CA193958/CA/NCI NIH HHS/United State

Desertification sensitivity analysis using medalus model and gis: A case study of the oases of middle draa valley, morocco

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Oases can play a significant role in the sustainable economic development of arid and Saharan regions. The aim of this study was to map the desertification-sensitive areas in the Middle Draa Valley (MDV), which is in the southeast of Morocco. A total of 13 indices that affect desertification processes were identified and analyzed using a geographic information system. The Mediterranean desertification and land use approach; which has been widely used in the Mediterranean regions due to its simplicity; flexibility and rapid implementation strategy; was applied. All the indices were grouped into four main quality indices; i.e., soil quality; climate quality; vegetation quality and management quality indices. Each quality index was constructed by the combination of several sub-indicators. In turn; the geometric mean of the four quality index maps was used to construct a map of desertification-sensitive areas; which were classified into four classes (i.e., low; moderate; high and very high sensitivity). Results indicated that only 16.63% of the sites in the study were classified as least sensitive to desertification; and 50.34% were classified as highly and very highly sensitive areas. Findings also showed that climate and human pressure factors are the most important indicators affecting desertification sensitivity in the MDV. The framework used in this research provides suitable results and can be easily implemented in similar oasis arid areas

Critical gap analysis of merging sections at Kuala Lumpur middle ring road

At merging sections, drivers normally slow down and sometimes need to stop while seeking a suitable gap before merging with the mainstream. Thus, there will always be several observed rejected gaps and an accepted gap which can be used to determine the smallest average gap, so-called critical gap. This study was carried out to determine critical gap values at selected merging sections at the Jalan Tun Razak and the DUKE Expressway uses the Maximum Likelihood method. Data were collected by using videotaping method and the gap acceptance data were extracted for analysis. A gap acceptance event at highway merging sections in this study was redefined due to unavailability of stopping vehicles at the ramp junction. Therefore, the gap data were estimated starting from a ramp’s vehicle passing the end of gore marking to where it merges with the mainstream. The analysis of the critical gap takes into consideration accepted gaps greater than 5 seconds to avoid forced entry due to lead impedance of successive vehicles on mainstream. The critical gap values obtained in this study, according to vehicle classification were ranged between 4.5 to 5.0 seconds, which are slightly smaller if compared to critical gap values for particularly left turn from minor movement at priority junction of the Arahan Teknik (Jalan) 11/87 and the United States Highway Capacity Manual 2000. The findings shall help to study driving behavior of local drivers, especially at priority control facilities such as merging sections

Performance and Emission Parameters of Single Cylinder Diesel Engine Using Castor Oil Bio-Diesel Blended Fuels

The purpose of this study is to investigate the performance and emission parameters of a CI single cylinder diesel engine operating on biodiesel-diesel blends (B0, B5, B10, B15 and E20: 20% biodiesel and 80% diesel by volume). A reactor was designed, fabricated and evaluated for biodiesel production. The results showed that increasing the biodiesel content in the blend fuel will increase the performance parameters and decrease the emission parameters. Maximum power was detected for B0 at 2650 rpm and maximum torque was belonged to B20 at 1600 rpm. The experimental results revealed that using biodiesel-diesel blended fuels increased the power and torque output of the engine. For biodiesel blends it was found that the specific fuel consumption (sfc) was decreased. B10 had the minimum amount for sfc. The concentration of CO2 and HC emissions in the exhaust pipe were measured and found to be decreased when biodiesel blends were introduced. This was due to the high oxygen percentage in the biodiesel compared to the net diesel fuel. In contrast, the concentration of CO and NOx was found to be increased when biodiesel is introduced

Performance evaluation of a scoria-compost biofilter treating xylene vapors

The removal of xylene vapors was studied in a biofilter packed with a new hybrid (scoria/compost) packing material at various inlet loads (IL) and empty bed residence times (EBRT) of 90, 60, and 40s. The best performance was observed for EBRT of 90s, where a removal efficiency of 98% was obtained under steady state condition for inlet xylene concentration of 1.34 g m(-3), while a maximum elimination capacity of 97.5 g m(-3) h(-1) was observed for IL of 199.5 g m(-3) h(-1). Carbon dioxide production rates and the microbial counts for xylene-degraders followed xylene elimination capacities. Overall look to the results of this study indicates that the scoria/compost mixture could be considered as a potential biofilter carrier, with low pressure drop (here <4 mm H2O), to treat air streams containing VOCs