633 research outputs found
The Evil of the Age : The Influence of The New York Times on Anti-Abortion Legislation in New York, 1865-1873
Pulsatile Dynamics in the Yeast Proteome
The activation of transcription factors in response to environmental conditions is fundamental to cellular regulation. Recent work has revealed that some transcription factors are activated in stochastic pulses of nuclear localization, rather than at a constant level, even in a constant environment. In such cases, signals control the mean activity of the transcription factor by modulating the frequency, duration, or amplitude of these pulses. Although specific pulsatile transcription factors have been identified in diverse cell types, it has remained unclear how prevalent pulsing is within the cell, how variable pulsing behaviors are between genes, and whether pulsing is specific to transcriptional regulators or is employed more broadly. To address these issues, we performed a proteome-wide movie-based screen to systematically identify localization-based pulsing behaviors in Saccharomyces cerevisiae. The screen examined all genes in a previously developed fluorescent protein fusion library of 4,159 strains in multiple media conditions. This approach revealed stochastic pulsing in ten proteins, all transcription factors. In each case, pulse dynamics were heterogeneous and unsynchronized among cells in clonal populations. Pulsing is the only dynamic localization behavior that we observed, and it tends to occur in pairs of paralogous and redundant proteins. Taken together, these results suggest that pulsatile dynamics play a pervasive role in yeast and may be similarly prevalent in other eukaryotic species
Prevalence of Cryptosporidium spp. infection in renal transplant and hemodialysis patients
Transplanted and hemodialysis patients are frequently affected by parasitic diseases such as cryptosporidiosis. Cryptosporidium is a parasite causing self-limited diarrhea and enteritis in healthy individuals. The presence of Cryptosporidium infection was studied in three groups including 87 renal transplant patients, 103 hemodialysis patients, and 60 healthy individuals as the control group. Two stool specimens were obtained from each case. The specimens were concentrated by the formalin-ether method and two smears were prepared from each. The smears were stained by modified acid-fast method and were observed under a light microscope. Ten (11.5) renal transplant and 4 (3.88) hemodialysis patients were positive for Cryptosporidium infection. No positive results were obtained in the control group. The results showed a statistically significant difference between renal transplant and control groups (P=0.02), but the difference between hemodialysis and control groups was not significant (P=0.2). The results also showed that the rate of Cryptosporidium infection in renal transplant patients was much higher than hemodialysis patients. The susceptibility of renal transplant patients to Cryptosporidium infection is much more than other studied groups and this could be due to immunosuppressive therapy in these patients
Prevalence of, risk factors for, and oxidative stress associated with Toxoplasma gondii antibodies among asymptomatic blood donors in Egypt
Effects of water temperature and migration time on some fecundity indices and fertilization rate of female Kutum, Rutilus frisii kutum,migratory to Shiroud River in the southwest Caspian Sea
Kutum, Rutilus frisii kutum, is an commercially important fish in the Caspian Sea. The fish enters the rivers leading to the Caspian Sea for spawning. One of these rivers is Shiroud River. In the artificial propagation process of Kutum, different factors are involved in quality and quantity of female broods eggs and also in the best temperature and migration time for spawning. The influence of temperature and migration time on some fecundity indices and fertilization rate of female kutum in Shiroud River was studied in the spawning season. In this study, 90 individual females were studied from February to May 2007. Averages of total length, weight and age were 43.26 cm, 832.08 g, and 4.41 respectively. Results showed that maximum egg diameter (1.86 mm), number of eggs per each gram of body weight (309.12), relative fecundity (56.21) and fertilization rate (95.82 %) were obtained from 5 to 20 April (15.95°C). Maximum ovary weight (201.00 g) and absolute fecundity of eggs (49987.18) were obtained from 6 to 20 March (17.74°C). Relationship between temperature and migration time and fecundity indices was linear and weak
Synovial cavernous hemangioma with juxta-articular hemangioma in a 29-year old woman: A case report
Introduction: Synovial hemangiomas are a rare benign vascular malformation that most commonly affects the knee joint, usually involving the anterior compartment. Histopathology examination is considered the gold standard for the diagnosis of synovial hemangioma. Surgical excision, either done per arthroscopy or per arthrotomy, is the treatment of choice. Presentation of case: This study presents a 29-year-old female admitted to our hospital in March 2020 who complained of continuous pain, swelling, and recurrent haemarthroses without a history of trauma for six months. The anteroposterior and lateral plain radiographs of the left knee showed no abnormality. An ultrasound of the left knee showed lobulated hypoechoic lesions in intra-articular and infra-suprapatellar pouches. Multiple vessels within the lesion with the low-velocity venous flow have appeared in color-Doppler imaging. Magnetic resonance imaging (MRI) of the left knee showed an irregular soft tissue mass in intra-articular fossa that infiltrating infra-suprapatellar pouches along to vastus medialis muscle (juxta-articular areas) measuring about 87 � 72 � 75 mm. Synovial effusion and bone erosions were notable. Fine-needle aspiration cytology (FNAC) offered hemarthrosis. The excisional biopsy obtained from the lesion and imprint cytology performed immediately after tissue removal. The cytologic diagnosis was compatible with a benign vascular neoplasm. The histologic exam confirmed synovial hemangioma. Discussion: Synovial hemangioma is a rare benign tumor of vascular origin arising from synovium-lined tissues, and often affects adolescents and young adults. Synovial hemangioma is often associated with an adjacent cutaneous or deep soft tissue hemangioma. It is a vascular malformation that contains variable amounts of adipose, fibrous, and muscle tissue, as well as thrombi in the vessels. At present, MRI has become the modality of choice for the evaluation of hemangiomas. The final diagnosis established with the histologic examination. The choice treatment is surgical excision. Conclusion: Although synovial hemangioma is a rare condition, be considered for non-specific clinical symptoms. However, an early diagnosis of synovial hemangioma is fundamental for adequate treatment. © 2020 The Author
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Feedback Control Systems for Non-Linear Simulation of Operational Transients in LMFBRs
Feedback control systems for non-linear simulation of operational transients in LMFBRs are developed. The models include (1) the reactor power control and rod drive mechanism, (2) sodium flow control and pump drive system, (3) steam generator flow control and valve actuator dynamics, and (4) the supervisory control. These models have been incorporated into the SSC code using a flexible approach, in order to accommodate some design dependent variations. The impact of system nonlinearity on the control dynamics is shown to be significant for severe perturbations. Representative result for a 10 cent and 25 cent step insertion of reactivity and a 10% ramp change in load in 40 seconds demonstrate the suitability of this model for study of operational transients without scram in LMFBRs
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A simplified model for calculating atmospheric radionuclide transport and early health effects from nuclear reactor accidents
During certain hypothetical severe accidents in a nuclear power plant, radionuclides could be released to the environment as a plume. Prediction of the atmospheric dispersion and transport of these radionuclides is important for assessment of the risk to the public from such accidents. A simplified PC-based model was developed that predicts time-integrated air concentration of each radionuclide at any location from release as a function of time integrated source strength using the Gaussian plume model. The solution procedure involves direct analytic integration of air concentration equations over time and position, using simplified meteorology. The formulation allows for dry and wet deposition, radioactive decay and daughter buildup, reactor building wake effects, the inversion lid effect, plume rise due to buoyancy or momentum, release duration, and grass height. Based on air and ground concentrations of the radionuclides, the early dose to an individual is calculated via cloudshine, groundshine, and inhalation. The model also calculates early health effects based on the doses. This paper presents aspects of the model that would be of interest to the prediction of environmental flows and their public consequences
Intraoperative 3-D mapping of parathyroid adenoma using freehand SPECT
Background: Freehand single photon emission computed tomography (fSPECT) is a three-dimensional (3-D) tomographic imaging modality based on data acquisition with a handheld detector that is moved freely, in contrast to conventional, gantry-mounted gamma camera systems. In this pilot study, we evaluated the feasibility of fSPECT for intraoperative 3-D mapping in patients with parathyroid adenomas.
Methods: Three patients (range 30 to 45 years) diagnosed with hyperparathyroidism (one primary and two tertiary) underwent parathyroid scintigraphy with technetium-99m sestamibi (99mTc-MIBI) to localize parathyroid adenomas. Two patients were referred with persistent hyperparathyroidism after conventional parathyroidectomy. In all three patients, a planar scintigraphy of the neck was performed 10 min after injection (p.i.) followed by SPECT/CT (Symbia T2, Siemens Healthcare) and a correlative ultrasound 2 h p.i. 99mTc-MIBI scan was performed the day before surgery in two patients and at the same day in one patient. fSPECT images were acquired intraoperatively using declipse SPECT (SurgicEyeTM).
Results: A total of five parathyroid adenomas were successfully located with SPECT/CT. fSPECT allowed intraoperative detection of all adenomas, and successful parathyroidectomy was accomplished. Parathyroid hormone level decreased intraoperatively in all three patients, on average, by 79% (range 72% to 91%).
Conclusion: In this preliminary study, we could demonstrate that intraoperative localization of parathyroid adenomas is feasible using the freehand SPECT technology, thus allowing an image-guided parathyroidectomy
Development and validation of a prehospital prediction model for acute traumatic coagulopathy
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