Nuclear factor kappa B as a potential target for pharmacological correction endothelium-associated pathology

The nuclear factor kappa B (NF-κB) is one of transcription factors. A high interest in studying the biological role of the signal system and its contribution to the development of cardiovascular, oncological and autoimmune diseases is obvious. A number of stimuli (proinflammatory cytokines: tumor necrosis factor α, interleukin 1β, ligand CD40 and others) trigger the canonical and non-canonical pathways of NF-κB signaling, which increase the expression of genes regulating synthesis of cytokines and chemokines, cell proliferation and differentiation, angiogenesis, immune reactions and apoptosis. However, pathological activation of NF-κB violates the balance of substances participating in the normal activity of the cardiovascular system. This leads to the development and progression of endothelium-associated pathology and comorbidit

Test system for evaluation of the influence of the biological activity of substances on the signal system of NF-κB: focus on the derivatives of 3- hydroxypyridine

At the first stage of our study, 11 pharmacological agents-inhibitors of NF-κB in vitro were screened with an estimate of the activity of the p65 subunit in mononuclear cells stimulated by bacterial lipopolysaccharide. The most active substances were: mexidol, ethoxidol and the agent under the code XS-9. Further inhibitory activity against NF-κB pharmacological agents was studied on 4 models: L-NAME-induced endothelial dysfunction, staphylococcal sepsis, acute toxic liver damage and acute pancreatiti

The development of Kondratieff’s theory of long waves: the place of the AI economy humanization in the ‘competencies-innovations-markets’ model

The motivation to conduct this study is related to the uncertainty of the impact of the AI economy on the economic cycle and the need to unlock the potential of Industry 4.0 in stabilizing the global economic system amid a series of crises. The article discusses the fundamental issues of the emergence of a new theory related to the evolution of Kondratieff waves in the context of modern drivers of long-term economic development (MANBRIC technologies), taking into account the acceleration of the development of innovations and competencies. The spiraling dynamics of the co-development of competencies and the expansion of new markets are shown, which makes it possible to transform the decline phase of the Kondratieff wave into a similar linear process of maintaining economic growth rates close to the existing ones. As a result, based on the authors’ model “competencies-innovations-markets”, it is proved that subject to humanization, the AI economy allows the reduction of the cyclical nature of the world economic system. The main idea of the article is to smooth out Kondratieff’s long waves due to the humanization of the AI economy. © 2023, The Author(s).RUDN UniversityThis paper has been supported by the RUDN University Strategic Academic Leadership Program

Association of genotypes of biotransformation enzymes with susceptibility to chronic pulmonary tuberculosis

Background. Now it is well-known that the pulmonary tuberculosis is a multifactorial disease in which forming a certain role belongs as factors external the environment, and genetic to factors. Aim. In this study, the association of genes of xenobiotic biotransformation enzymes: NAT2 [590GA (rs1799930)], CYP2E1 [9896CG (rs2070676)], ABCB1 [3435TC (rs1045642)], GSTM1 (E/D) and GSTT1 (E/D) with susceptibility to torpid pulmonary tuberculosis was carried out. Materials and methods. 123 people suffering from torpid pulmonary tuberculosis were included in the study. Genomic DNA was isolated using Arrow Blood DNA 500 reagent kits from whole blood (at the NorDiag Arrow station). Next, the polymerase chain reaction was staged in real time using sets of reagents for SNPs genotyping. Results. The study showed an association of gene polymorphisms of xenobiotic biotransformation enzymes with susceptibility to torpid pulmonary tuberculosis, including certain clinical forms of pulmonary tuberculosis. Conclusion. During the conducted research it was established that implementation of results of genotyping of enzymes of biotransformation of xenobiotics in practice of the doctor of the phthisiatrician for the purpose of forming of risk groups of suffering from tuberculosis lungs which have a susceptibility probability to this disease that perhaps in the future will provide the individualized approach to prevention and treatment of these patients is necessary

Test system for evaluation of the influence of the biological activity of substances on the signal system of NF-κB: focus on the derivatives of 3- hydroxypyridine

At the first stage of our study, 11 pharmacological agents-inhibitors of NF-κB in vitro were screened with an estimate of the activity of the p65 subunit in mononuclear cells stimulated by bacterial lipopolysaccharide. The most active substances were: mexidol, ethoxidol and the agent under the code XS-9. Further inhibitory activity against NF-κB pharmacological agents was studied on 4 models: L-NAME-induced endothelial dysfunction, staphylococcal sepsis, acute toxic liver damage and acute pancreatiti

Nuclear factor kappa B as a potential target for pharmacological correction endothelium-associated pathology

The nuclear factor kappa B (NF-κB) is one of transcription factors. A high interest in studying the biological role of the signal system and its contribution to the development of cardiovascular, oncological and autoimmune diseases is obvious. A number of stimuli (proinflammatory cytokines: tumor necrosis factor α, interleukin 1β, ligand CD40 and others) trigger the canonical and non-canonical pathways of NF-κB signaling, which increase the expression of genes regulating synthesis of cytokines and chemokines, cell proliferation and differentiation, angiogenesis, immune reactions and apoptosis. However, pathological activation of NF-κB violates the balance of substances participating in the normal activity of the cardiovascular system. This leads to the development and progression of endothelium-associated pathology and comorbidit

The development of Kondratieff’s theory of long waves: the place of the AI economy humanization in the ‘competencies-innovations-markets’ model

Abstract The motivation to conduct this study is related to the uncertainty of the impact of the AI economy on the economic cycle and the need to unlock the potential of Industry 4.0 in stabilizing the global economic system amid a series of crises. The article discusses the fundamental issues of the emergence of a new theory related to the evolution of Kondratieff waves in the context of modern drivers of long-term economic development (MANBRIC technologies), taking into account the acceleration of the development of innovations and competencies. The spiraling dynamics of the co-development of competencies and the expansion of new markets are shown, which makes it possible to transform the decline phase of the Kondratieff wave into a similar linear process of maintaining economic growth rates close to the existing ones. As a result, based on the authors’ model “competencies-innovations-markets”, it is proved that subject to humanization, the AI economy allows the reduction of the cyclical nature of the world economic system. The main idea of the article is to smooth out Kondratieff’s long waves due to the humanization of the AI economy

Perspectives of solving the problems of regional development with the help of new internet technologies

International audienceThe purpose of the work is to determine the key problems of regional development in modern Russia and to substantiate the perspectives and model the process of their solving with the help of new Internet technologies. For full coverage of the problems of regional development in modern Russia, they are analyzed from the positions of public perception and level of dynamics of the statistical data that characterize these problems. At that, the methods of logical and statistical analysis are used. The information and analytical basis of the research includes the materials of the All-Russian Public Opinion Research Center, Federal State Statistics Service of the Russian Federation, and independence expert and analytical organization RIA Ranking for 2014-2017. As a result, the authors substantiate that implementation of new Internet technologies is a perspective means of solving the problems of regional development in modern Russia. These problems concern optimality of interaction of non-government economic subjects (society and entrepreneurship) between each other, which leads to low business activity, complexity of employment, and low income, and non-optimality of interaction between non-government economic subjects and the state, which leads to inaccessibility and low quality of state services and public benefits, including healthcare, communal and housing sphere, infrastructure, etc. Implementation of new Internet technologies into entrepreneurship allows reducing its capital intensity, increasing business activity, simplifying the process of employment, and increasing accessibility (reduce cost) of goods and services for the population. Due to implementation of new Internet technologies into activities of state organizations, which provide state services and public benefits, their controllability and manageability by society is achieved – which stimulates increase of their quality and accessibility. A proprietary model of solving the problems of regional development in modern Russia with the help of new Internet technologies is developed