HIGH ACCEPTABILITY OF COTRIMOXAZOLE AND ANTIRETROVIRAL TREATMENT AMONG HIV INFECTED TUBERCULOSIS PATIENTS OFFERED INTEGRATE

Cape Town TB Conferenc

Idiopathic CD4+ T-lymphocytopenia with cryptococcal meningitis: first case report from Cambodia.

We report on a patient with cryptococcal meningitis with CD4+ T-lymphocytopenia and no evidence of HIV infection

Early mortality (pre and post antiretroviral treatment) amongst children with HIV/AIDS enrolled in two programs in Cambodia

Mexico AIDS Conference 200

Cervial cancer screening among HIV-positive women in rural Cambodia: a pilot programme

Mexico AIDS Conference 200

Managing complex taxonomic data in an object-oriented database.

This thesis addresses the problem of multiple overlapping classifications in object-oriented databases through the example of plant taxonomy. These multiple overlapping classifications are independent simple classifications that share information (nodes and leaves), therefore overlap. Plant taxonomy was chosen as the motivational application domain because taxonomic classifications are especially complex and have changed over long periods of time, therefore overlap in a significant manner. This work extracts basic requirements for the support of multiple overlapping classifications in general, and in the context of plant taxonomy in particular. These requirements form the basis on which a prototype is defmed and built. The prototype, an extended object-oriented database, is extended from an object-oriented model based on ODMG through the provision of a relationship management mechanism. These relationships form the main feature used to build classifications. This emphasis on relationships allows the description of classifications orthogonal to the classified data (for reuse and integration of the mechanism with existing databases and for classification of non co-operating data), and allows an easier and more powerful management of semantic data (both within and without a classification). Additional mechanisms such as integrity constraints are investigated and implemented. Finally, the implementation of the prototype is presented and is evaluated, from the point of view of both usability and expressiveness (using plant taxonomy as an application), and its performance as a database system. This evaluation shows that the prototype meets the needs of taxonomists

Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes.

This paper describes the effectiveness of first-line regimens for stage 2 human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense infection in nine Médecins Sans Frontières HAT treatment programmes in Angola, Republic of Congo, Sudan and Uganda. Regimens included eflornithine and standard- and short-course melarsoprol. Outcomes for 10461 naïve stage 2 patients fitting a standardised case definition and allocated to one of the above regimens were analysed by intention-to-treat analysis. Effectiveness was quantified by the case fatality rate (CFR) during treatment, the proportion probably and definitely cured and the Kaplan-Meier probability of relapse-free survival at 12 months and 24 months post admission. The CFR was similar for the standard- and short-course melarsoprol regimens (4.9% and 4.2%, respectively). The CFR for eflornithine was 1.2%. Kaplan-Meier survival probabilities varied from 71.4-91.8% at 1 year and 56.5-87.9% at 2 years for standard-course melarsoprol, to 73.0-91.1% at 1 year for short-course melarsoprol, and 79.9-97.4% at 1 year and 68.6-93.7% at 2 years for eflornithine. With the exception of one programme, survival at 12 months was >90% for eflornithine, whilst for melarsoprol it was <90% except in two sites. Eflornithine is recommended where feasible, especially in areas with low melarsoprol effectiveness

Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes

This paper describes the effectiveness of first-line regimens for stage 2 human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense infection in nine Médecins Sans Frontières HAT treatment programmes in Angola, Republic of Congo, Sudan and Uganda. Regimens included eflornithine and standard- and short-course melarsoprol. Outcomes for 10461 naïve stage 2 patients fitting a standardised case definition and allocated to one of the above regimens were analysed by intention-to-treat analysis. Effectiveness was quantified by the case fatality rate (CFR) during treatment, the proportion probably and definitely cured and the Kaplan-Meier probability of relapse-free survival at 12 months and 24 months post admission. The CFR was similar for the standard- and short-course melarsoprol regimens (4.9% and 4.2%, respectively). The CFR for eflornithine was 1.2%. Kaplan-Meier survival probabilities varied from 71.4-91.8% at 1 year and 56.5-87.9% at 2 years for standard-course melarsoprol, to 73.0-91.1% at 1 year for short-course melarsoprol, and 79.9-97.4% at 1 year and 68.6-93.7% at 2 years for eflornithine. With the exception of one programme, survival at 12 months was >90% for eflornithine, whilst for melarsoprol it was <90% except in two sites. Eflornithine is recommended where feasible, especially in areas with low melarsoprol effectivenes