A Case of Multiple Sclerosis Presenting as Eight and Half Syndrome.

Multiple sclerosis (MS) is a chronic disease characterized by inflammation, demyelination, gliosis (scarring), and neuronal loss; the course can be relapsing-remitting or progressive. Manifestations of MS vary from a benign illness to a rapidly evolving and incapacitating disease requiring profound lifestyle adjustments. We report a 24 year old female who presented with right internuclear ophthalmoplegia with right lower motor neuron facial nerve palsy which is called eight and half syndrome. The etiology in our patient was multiple sclerosis which was confirmed by radio-imaging studies. Patient improved on pulse therapy of methyl prednisolone and tapering dose of steroids

COLLECTORS FOR ENABLING FLOTATION OF OXIDIZED COAL

The coalburg seam coal is an example of difficult to float bituminous coal. Laboratory tests conducted on coalburg flotation feed sample revealed recovery values around 28% with 15% product ash when using fuel oil as collector under natural pH conditions. A detailed study showed that increasing pH from natural value of 5.6 to 7.5 provided a significant improvement in recovery of approximately 32 absolute percentage points. The improvement is believed to be result of the release of humic acids from the surface and the dispersion of clay particles thereby leaving a more hydrophobic surface. Based on the tests conducted with various commercially available collectors, oleic acid was selected as a model collector for oxidized coals. Conventional flotation tests found an increase in combustible recovery of 10 absolute percentage points above the pH improvement using 4:1 blend of fuel oil and oleic acid. The problem of higher ash in conventional cell product due to entrainment was minimized by the use of wash water in a flotation column. A flotation concentrate containing less than 7.5% ash was produced while recovering around 75% of the combustible material. Further testing using fatty acids-fuel oil blend also showed evidence of a near 200% increase in flotation rate

Out of Scandinavia: The History and Contributions of an IS Research Tradition

This summer, the Scandinavian IS research community celebrated its 21st annual IRIS conference (Information systems Research In Scandinavia), and from that point of view it is probably the oldest active IS research community in the world. Many important contributions have come out of this tradition: for example, the work of Börje Langefors on theories of information systems (1966), which contributed to the establishment of our field, and the controversial contributions of Kristen Nygaard (1971), emphasizing the political aspects and the strengths of action research approaches as integral parts of information systems studies

Another shock for the Bullet cluster, and the source of seed electrons for radio relics

With Australia Telescope Compact Array observations, we detect a highly elongated Mpc-scale diffuse radio source on the eastern periphery of the Bullet cluster 1E0657-55.8, which we argue has the positional, spectral and polarimetric characteristics of a radio relic. This powerful relic (2.3+/-0.1 x 10^25 W Hz^-1) consists of a bright northern bulb and a faint linear tail. The bulb emits 94% of the observed radio flux and has the highest surface brightness of any known relic. Exactly coincident with the linear tail we find a sharp X-ray surface brightness edge in the deep Chandra image of the cluster -- a signature of a shock front in the hot intracluster medium (ICM), located on the opposite side of the cluster to the famous bow shock. This new example of an X-ray shock coincident with a relic further supports the hypothesis that shocks in the outer regions of clusters can form relics via diffusive shock (re-)acceleration. Intriguingly, our new relic suggests that seed electrons for reacceleration are coming from a local remnant of a radio galaxy, which we are lucky to catch before its complete disruption. If this scenario, in which a relic forms when a shock crosses a well-defined region of the ICM polluted with aged relativistic plasma -- as opposed to the usual assumption that seeds are uniformly mixed in the ICM -- is also the case for other relics, this may explain a number of peculiar properties of peripheral relics.Comment: 10 pages, 9 figures, 1 table, accepted for publication in MNRA

Bayesian inference of substrate properties from film behavior

We demonstrate that by observing the behavior of a film deposited on a substrate, certain features of the substrate may be inferred with quantified uncertainty using Bayesian methods. We carry out this demonstration on an illustrative film/substrate model where the substrate is a Gaussian random field and the film is a two-component mixture that obeys the Cahn–Hilliard equation. We construct a stochastic reduced order model to describe the film/substrate interaction and use it to infer substrate properties from film behavior. This quantitative inference strategy may be adapted to other film/substrate systems.United States. Dept. of Energy. Office of Basic Energy Sciences (Award DE-SC0008926

Structural basis of mitochondrial receptor binding and constriction by DRP1.

Mitochondrial inheritance, genome maintenance and metabolic adaptation depend on organelle fission by dynamin-related protein 1 (DRP1) and its mitochondrial receptors. DRP1 receptors include the paralogues mitochondrial dynamics proteins of 49 and 51 kDa (MID49 and MID51) and mitochondrial fission factor (MFF); however, the mechanisms by which these proteins recruit and regulate DRP1 are unknown. Here we present a cryo-electron microscopy structure of full-length human DRP1 co-assembled with MID49 and an analysis of structure- and disease-based mutations. We report that GTP induces a marked elongation and rotation of the GTPase domain, bundle-signalling element and connecting hinge loops of DRP1. In this conformation, a network of multivalent interactions promotes the polymerization of a linear DRP1 filament with MID49 or MID51. After co-assembly, GTP hydrolysis and exchange lead to MID receptor dissociation, filament shortening and curling of DRP1 oligomers into constricted and closed rings. Together, these views of full-length, receptor- and nucleotide-bound conformations reveal how DRP1 performs mechanical work through nucleotide-driven allostery

Timelines of Transportation Infrastructure Delivery 2000 to 2018 in Toronto, Canada and London, UK

This paper explores the timelines of large transportation infrastructure delivery, from first proposal to construction and opening in London, UK and Toronto, Canada. The goal of the paper is to identify both how long it takes projects to go from idea to delivery, the relative time of different stages in the delivery process, and if projects with long timelines see physical or technological changes in their design. This work contributes to two ongoing discussions around the speed of infrastructure delivery, one that argues infrastructure moves too slowly and major efforts are needed to speed delivery and another that argues that good infrastructure thinking requires time to breathe and care should be taken in rushing through the delivery process. Detailed delivery timelines from initial proposal to construction or operation are developed for 26 transportation projects (16 in Toronto and 10 in London) between the years 2000 and 2018. For each project the timelines of inception, approval, planning, procurement, environmental assessment, construction and operational phases are identified and compared. Long informal gestation periods are identified for many projects, particularly for linear projects. In many instances the informal gestation period dwarfs the time projects spent in formal planning. This research highlights the need to expand the conception of timeliness of infrastructure delivery to include the lengthy periods of informal debate and planning that can span years and build up community expectations about the imminence of a project, even before it has received formal assessment or approval

Pre-operative fixed flexion deformity a curse to the knee arthroplasty surgeon?

Background: The aim of the study was to study the effect of preoperative flexion deformity on the postoperative knee range of motion following total knee arthroplasty.Methods: A total of 28 knees were studied out of which twenty were osteoarthritis and eight were rheumatoid arthritis. Cruciate substituting and cruciate retaining implants were used. Patients above the age of 45 years with a minimum follow up period of two years from April 2010 were studied.Results: 28 knees had an average preoperative range of motion of 87.678. Patients with preoperative flexion deformity had postoperative range of motion of 97.5 degrees. The average postoperative flexion in 8 rheumatoid patients was 96.25 and 20 osteoarthritis patients was 107.462.Conclusions: The average postoperative range of motion was 105.538. Patients with a higher pre-operative range of motion had higher postoperative range of motion. Rheumatoid patients had a significantly low range of motion when compared to osteoarthritis patients. Patients with increased fixed flexion deformity had a significantly low postoperative range of motion