Effects of Transcranial Direct Current Stimulation of Primary Motor Cortex on Reaction Time and Tapping Performance: A Comparison Between Athletes and Non-athletes

Recent studies provided compelling evidence that physical activity leads to specific changes on a functional and structural level of brain organization. The observed neural adaptions are specific to the sport and manifested in those brain regions which are associated with neuronal processing of sport-specific skills. Techniques of non-invasive brain stimulation have been shown to induce neuroplastic changes and thereby also facilitate task performance. In the present study, we investigated the influence of transcranial direct current stimulation (tDCS) over the leg area of the primary motor cortex (M1) on simple reaction time tasks (RTT) and tapping tasks (TT) as a comparison between trained football (FB) and handball players (HB) and non-athletes (NA). We hypothesized that anodal tDCS over M1 (leg area) would lead to specific behavioral gains in RTT and TT performance of the lower extremity as compared to sham condition. On an exploratory level, we aimed at revealing if trained athletes would show stronger tDCS-induced behavioral gains as compared to NA, and, furthermore, if there are any differential effects between FB and HB. A total number of 46 participants were enrolled in a sham-controlled, double-blinded, cross-over study. A test block consisting of RTT and TT was performed before, during, after as well as 30 min after a 20-min tDCS application. Additionally, the specificity of tDCS-induced changes was examined by testing upper extremity using the same experimental design as a control condition. Our data showed no group- or sport-specific tDCS-induced effects (online and offline) on RTT and TT neither for lower nor upper extremities. These findings indicate that neither athletes nor NA seems to benefit from a brief period of tDCS application in speed-related motor tasks. However, more knowledge on neuronal processing of RTT and TT performance in trained athletes, the influence of tDCS parameters including stimulation sites, and the effect of inter-individual differences are required in order to draw a comprehensive picture of whether tDCS can help to enhance motor abilities on a high-performance level

Whole-body sensorimotor skill learning in football players: No evidence for motor transfer effects

Besides simple movement sequences, precise whole-body motor sequences are fundamental for top athletic performance. It has long been questioned whether athletes have an advantage when learning new whole-body motor sequences. In a previous study, we did not find any superior learning or transfer effects of strength and endurance athletes in a complex whole-body serial reaction time task (CWB-SRTT). In the present study, we aimed to extend this research by increasing the overlap of task requirements between CWB-SRTT and a specific sports discipline. For this purpose, we assessed differences between football players and non-athletes during motor sequence learning using CWB-SRTT. 15 non-athletes (CG) and 16 football players (FG) performed the CWB-SRTT over 2 days separated by one week. Median reaction times and movement times were analyzed as well as differences in sequence-specific CWB-SRTT learning rates and retention. Our findings did not reveal any differences in sequence-specific or non-sequence-specific improvement, nor retention rates between CG and FG. We speculate that this might relate to a predominately cognitive-induced learning effect during CWB-SRTT which negates the assumed motor advantage of the football players

Somatosensory-evoked potentials as a marker of functional neuroplasticity in athletes: A systematic review

Background: Somatosensory-evoked potentials (SEP) represent a non-invasive tool to assess neural responses elicited by somatosensory stimuli acquired via electrophysiological recordings. To date, there is no comprehensive evaluation of SEPs for the diagnostic investigation of exercise-induced functional neuroplasticity. This systematic review aims at highlighting the potential of SEP measurements as a diagnostic tool to investigate exercise-induced functional neuroplasticity of the sensorimotor system by reviewing studies comparing SEP parameters between athletes and healthy controls who are not involved in organized sports as well as between athlete cohorts of different sport disciplines. Methods: A systematic literature search was conducted across three electronic databases (PubMed, Web of Science, and SPORTDiscus) by two independent researchers. Three hundred and ninety-seven records were identified, of which 10 cross-sectional studies were considered eligible. Results: Differences in SEP amplitudes and latencies between athletes and healthy controls or between athletes of different cohorts as well as associations between SEP parameters and demographic/behavioral variables (years of training, hours of training per week & reaction time) were observed in seven out of 10 included studies. In particular, several studies highlight differences in short- and long-latency SEP parameters, as well as high-frequency oscillations (HFO) when comparing athletes and healthy controls. Neuroplastic differences in athletes appear to be modality-specific as well as dependent on training regimens and sport-specific requirements. This is exemplified by differences in SEP parameters of various athlete populations after stimulation of their primarily trained limb. Conclusion: Taken together, the existing literature suggests that athletes show specific functional neuroplasticity in the somatosensory system. Therefore, this systematic review highlights the potential of SEP measurements as an easy-to-use and inexpensive diagnostic tool to investigate functional neuroplasticity in the sensorimotor system of athletes. However, there are limitations regarding the small sample sizes and inconsistent methodology of SEP measurements in the studies reviewed. Therefore, future intervention studies are needed to verify and extend the conclusions drawn here

Single-session anodal transcranial direct current stimulation to enhance sport-specific performance in athletes: A systematic review and meta-analysis

BackgroundTranscranial direct current stimulation (tDCS) has emerged as a promising and feasible method to improve motor performance in healthy and clinical populations. However, the potential of tDCS to enhance sport-specific motor performance in athletes remains elusive.ObjectiveWe aimed at analyzing the acute effects of a single anodal tDCS session on sport-specific motor performance changes in athletes compared to sham.MethodsA systematic review and meta-analysis was conducted in the electronic databases PubMed, Web of Science, and SPORTDiscus. The meta-analysis was performed using an inverse variance method and a random-effects model. Additionally, two subgroup analyses were conducted (1) depending on the stimulated brain areas (primary motor cortex (M1), temporal cortex (TC), prefrontal cortex (PFC), cerebellum (CB)), and (2) studies clustered in subgroups according to different sports performance domains (endurance, strength, visuomotor skill).ResultsA total number of 19 studies enrolling a sample size of 258 athletes were deemed eligible for inclusion. Across all included studies, a significant moderate standardized mean difference (SMD) favoring anodal tDCS to enhance sport-specific motor performance could be observed. Subgroup analysis depending on cortical target areas of tDCS indicated a significant moderate SMD in favor of anodal tDCS compared to sham for M1 stimulation.ConclusionA single anodal tDCS session can lead to performance enhancement in athletes in sport-specific motor tasks. Although no definitive conclusions can be drawn regarding the modes of action as a function of performance domain or stimulation site, these results imply intriguing possibilities concerning sports performance enhancement through anodal M1 stimulation

Effects of short-term dynamic balance training on postural stability in school-aged football players and gymnasts

Static and dynamic balance abilities enable simple and complex movements and are determinants of top athletic performance. Balance abilities and their proficiency differ fundamentally with respect to age, gender, type of balance intervention, and type of sport. With this study, we aim to investigate whether 4weeks of dynamic balance training (DBT) improves static balance performance in school-aged gymnasts and football players. For this purpose, young male gymnasts (n=21) and male football players (n=20) completed an initial static balance assessment consisting of two one-legged stance (left and right foot) and two two-legged stance (eyes open and eyes closed) tasks. Subsequently, all participants underwent a 4-week intervention. DBT consisting of nine individual tasks was performed two times per week. Another static balance assessment followed 1day after the last training session and retention was assessed 2weeks later. Dynamic balance scores and total path length were analyzed via rank-based repeated measures designs using ANOVA-type statistics. The influence of factors GROUP and TIME on the static and dynamic balance performance was examined. Prior to DBT, young gymnasts showed better static balance performance than football players. However, after intervention, both groups improved in both one-legged stance tasks and also had high retention rates in these tasks. No significant improvements were seen in either group in the two-legged balance tests. Both groups improved in the dynamic balance tasks, although no differences in learning rates were evident. Our findings imply an inter-relationship between both static and dynamic balance components. Consequently, training regimes should include both balance components to facilitate early development of balance ability

No Overt Effects of a 6-Week Exergame Training on Sensorimotor and Cognitive Function in Older Adults. A Preliminary Investigation

Several studies investigating the relationship between physical activity and cognition showed that exercise interventions might have beneficial effects on working memory, executive functions as well as motor fitness in old adults. Recently, movement based video games (exergames) have been introduced to have the capability to improve cognitive function in older adults. Healthy aging is associated with a loss of cognitive, as well as sensorimotor functions. During exergaming, participants are required to perform physical activities while being simultaneously surrounded by a cognitively challenging environment. However, only little is known about the impact of exergame training interventions on a broad range of motor, sensory, and cognitive skills. Therefore, the present study aims at investigating the effects of an exergame training over 6 weeks on cognitive, motor, and sensory functions in healthy old participants. For this purpose, 30 neurologically healthy older adults were randomly assigned to either an experimental (ETG, n = 15, 1 h training, twice a week) or a control group (NTG, n = 15, no training). Several cognitive tests were performed before and after exergaming in order to capture potential training-induced effects on processing speed as well as on executive functions. To measure the impact of exergaming on sensorimotor performance, a test battery consisting of pinch and grip force of the hand, tactile acuity, eye-hand coordination, flexibility, reaction time, coordination, and static balance were additionally performed. While we observed significant improvements in the trained exergame (mainly in tasks that required a high load of coordinative abilities), these gains did not result in differential performance improvements when comparing ETG and NTG. The only exergaming- induced difference was a superior behavioral gain in fine motor skills of the left hand in ETG compared to NTG. In an exploratory analysis, within-group comparison revealed improvements in sensorimotor and cognitive tasks (ETG) while NTG only showed an improvement in a static balance test. Taken together, the present study indicates that even though exergames might improve gaming performance, our behavioral assessment was probably not sensitive enough to capture exergaming-induced improvements. Hence, we suggest to use more tailored outcome measures in future studies to assess potential exergaming- induced changes

No overt effects of a 6-week exergame training on sensorimotor and cognitive function in older adults: A preliminary investigation

Several studies investigating the relationship between physical activity and cognition showed that exercise interventions might have beneficial effects on working memory, executive functions as well as motor fitness in old adults. Recently, movement based video games (exergames) have been introduced to have the capability to improve cognitive function in older adults. Healthy aging is associated with a loss of cognitive, as well as sensorimotor functions. During exergaming, participants are required to perform physical activities while being simultaneously surrounded by a cognitively challenging environment. However, only little is known about the impact of exergame training interventions on a broad range of motor, sensory, and cognitive skills. Therefore, the present study aims at investigating the effects of an exergame training over 6 weeks on cognitive, motor, and sensory functions in healthy old participants. For this purpose, 30 neurologically healthy older adults were randomly assigned to either an experimental (ETG, n = 15, 1 h training, twice a week) or a control group (NTG, n = 15, no training). Several cognitive tests were performed before and after exergaming in order to capture potential training-induced effects on processing speed as well as on executive functions. To measure the impact of exergaming on sensorimotor performance, a test battery consisting of pinch and grip force of the hand, tactile acuity, eye-hand coordination, flexibility, reaction time, coordination, and static balance were additionally performed. While we observed significant improvements in the trained exergame (mainly in tasks that required a high load of coordinative abilities), these gains did not result in differential performance improvements when comparing ETG and NTG. The only exergaming-induced difference was a superior behavioral gain in fine motor skills of the left hand in ETG compared to NTG. In an exploratory analysis, within-group comparison revealed improvements in sensorimotor and cognitive tasks (ETG) while NTG only showed an improvement in a static balance test. Taken together, the present study indicates that even though exergames might improve gaming performance, our behavioral assessment was probably not sensitive enough to capture exergaming-induced improvements. Hence, we suggest to use more tailored outcome measures in future studies to assess potential exergaming-induced changes

Changes of hand switching costs during bimanual sequential learning

Many tasks in our daily life demand not only the use of different fingers of one hand in a serial fashion, but also to alternate from one hand to the other. Here, we investigated performance in a bimanual serial reaction time task (SRTT) with particular emphasis on learning-related changes in reaction time (RT) for consecutive button presses for homologous index- and middle fingers. The bimanual SRTT consisted of sequential button presses either with the left or right index- and middle-finger to a series of visual letters displayed on a computer screen. Each letter was assigned a specific button press with one of four fingers. Two outcome measures were investigated: (a) global sequence learning as defined by the time needed to complete a 15-letter SRTT sequence and (b) changes in hand switch costs across learning. We found that bimanual SRTT resulted in a global decrease in RT during the time course of learning that persisted for at least two weeks. Furthermore, RT to a button press showed an increase when the previous button press was associated with another hand as opposed to the same hand. This increase in RT was defined as switch costs. Hand switch costs significantly decreased during the time course of learning, and remained stable over a time of approximately two weeks. This study provides evidence for modulations of switch costs during bimanual sequence learning, a finding that might have important implications for theories of bimanual coordination and learning

Cerebellar Transcranial Direct Current Stimulation Improves Maximum Isometric Force Production during Isometric Barbell Squats

Maximum voluntary contraction force (MVC) is an important predictor of athletic performance as well as physical fitness throughout life. Many everyday life activities involve multi-joint or whole-body movements that are determined in part through optimized muscle strength. Transcranial direct current stimulation (tDCS) has been reported to enhance muscle strength parameters in single-joint movements after its application to motor cortical areas, although tDCS effects on maximum isometric voluntary contraction force (MIVC) in compound movements remain to be investigated. Here, we tested whether anodal tDCS and/or sham stimulation over primary motor cortex (M1) and cerebellum (CB) improves MIVC during isometric barbell squats (iBS). Our results provide novel evidence that CB stimulation enhances MIVC during iBS. Although this indicates that parameters relating to muscle strength can be modulated through anodal tDCS of the cerebellum, our results serve as an initial reference point and need to be extended. Therefore, further studies are necessary to expand knowledge in this area of research through the inclusion of different tDCS paradigms, for example investigating dynamic barbell squats, as well as testing other whole-body movements

Comparison of whole-body sensorimotor skill learning between strength athletes, endurance athletes and healthy sedentary adults

Motor sequences represent an integral part of human motor ability. Apart from simple movement sequences, complex coordinated movement sequences are the building blocks for peak athletic performance. Accordingly, optimized temporal and spatial coordination of muscle action across multiple limbs may be a distinguishing feature between athletes and non-athletes in many sports. In the present study, we aimed to assess differences between strength and endurance athletes and non-athletes during learning of a complex whole-body serial reaction time task (CWB-SRTT). For this purpose, 26 nonathletes (NAG) and 25 athletes (AG) learned the CWB-SRTT over 2 days separated by 7 days. Mean response times of participants were recorded and statistically analyzed for sequence-specific and non-sequence-specific improvements, as well as differences in learning rates and retention. Furthermore, AG was subdivided into strength (SG) and endurance (EG) athletes, and all analysis steps were repeated. Our results show a better mean response time of AG compared to NAG. However, we could not detect differences in sequence-specific or non-sequence-specific learning, as well as different retention rates between NAG and AG or SG and EG. We assume here that a potential lack of motor transfer between general athletic abilities and the specific complex motor sequence mainly accounts for our findings