La actuación de las Fuerzas y Cuerpos de Seguridad en la investigación y persecución de los menores en las redes sociales

Desde una perspectiva práctica, la ponencia irá dirigida a enseñar a los asistentes cuales son los riesgos que un mal uso de las nuevas tecnologías de la información y de la comunicación podrían acarrear, haciendo especial hincapié al uso que los menores de edad realizan de éstas. Igualmente se expondrá, de manera resumida, cual es el procedimiento que el Cuerpo Nacional de Policía lleva a cabo desde el momento en el que tiene conocimiento de la realización de alguna de las practicas que actualmente están tan de moda entre menores de edad, como son el grooming, el sexting o el ciberbullying.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Arquitectura por horas

Los alumnos de proyectos 2 [grupos 9+11] de la E.T.S.A.S. realizan como ejercicio final de curso la acción urbana denominada “arquitectura por horas”, que se muestra en un contexto muy concurrido, La Puerta de Jerez y los espacios de la Casa de la Moneda de Sevilla. Los estudiantes, con esa acción colectiva, persiguen que los habitantes de la calle interactúen con una performance de objetos y descubrir en las reacciones los mecanismos que producen interacciones. La acción convierte la calle en un laboratorio social donde convergen acciones y respuestas. La actividad, que se ha desarrollado bajo el lema 'Reducir, reciclar, reutilizar'. Cinco acciones de ámbito académico pensadas para un contexto urbano que se recicla: usamos su materialidad y añadimos otros materiales procedentes de reciclajes: plástico, papel, metal, neumáticos, embalajes,… Cinco colores concurren sobre el tablero de juego: Negro, rojo, (blanco – verde), (amarillo – ocre), azul. Un contexto, la Casa de la Moneda y su entorno inmediato, previamente analizado y conocido. Las propuestas intentan conjugar planteamientos conceptuales con un proceso metódico de alegorías visuales, que son extremadamente sencillas y no están exentas de humor e ironía. Cinco Instalaciones efímeras que en cinco horas, se montan, interactúan y desaparecen. Se diseña un foro de intercambio de experiencias entre profesores, alumnos, viandantes,... La arquitectura como objeto y descubrimiento que desvela, superado el objeto en sí, como actúa sobre los sujetos y cual es su capacidad de provocar situaciones. El paseante toma partido ante lo insólito, inusual, inesperado,... y la experiencia se convierte en celebración de los pobladores de la calle. Sabemos que lo inusual, en ocasiones pasa inadvertido y en otras se presenta como revulsivo o subversivo. Durante cinco horas registramos imágenes del tránsito para documentar las respuestas a las provocaciones, el comportamiento del espectador ante el objeto. Acciones de réplica o indiferencias.The E.T.S.A.S. students from the course Proyectos2 [groups 9 and 11] performed as final exercise the urban action called “Architecture per hours”, within a concurred context: La Puerta de Jerez and the spaces from la Casa de la Moneda de Sevilla. The students pursue through this collective action that the people on the street interact through a performance with objects so the students can find out by their reactions the motions that the interactions generate. This performance turns the streets into a social laboratory where actions and responses are being converged. In addition, this activity has been worked out by the theme “Reduce, recycle, reuse”. The result is five educational actions thought for a specific context where recycling is important: we use its materiality and we add different materials of recycling, such as plastic, paper, metal, tires, cardboards… Five different colors are being played on the game board: black, red, whitegreen, yellow-ocher and blue. One concrete context: la Casa de la Moneda and its closest surroundings, which we previously analyzed and studied. The proposals try to mix up conceptual ideas with an intentional visual game, whose intentions are extremely simple and not far from humor and irony. In conclusion, five ephemeral interventions which are built, used and disappeared in only five hours. It is designed an exchange forum of collective experiences between professors, students, people on the street… Architecture is like an object which once is overcome, it can find out how to interact with the subjects and how far it can get to provoke a situation. The walking person takes part confronting the unusual, the extraordinary, the unexpected… So this experience is turned into a celebration by its public. We all know that the unusual is rarely noticed except when it shows revulsion or subversive. For more than five hours we recorded images and videos of the public flux so we could document the diverse responses and reactions caused by the objects, even the revulsion actions or the indifferent behaviors

Oxidation of lignocellulosic platform molecules to value-added chemicals using heterogeneous catalytic technologies

Currently, much attention is being paid to the development of sustainable catalytic processes for the production of chemicals (biofuels, bioproducts, and so on) from lignocellulosic biomass. This minireview pursues to give an exhaustive overview about the heterogeneous catalytic technologies proposed for the oxidation of four key platform molecules (glucose, 5-hydroxymethylfurfural, furfural and levulinic acid) into important chemicals, such as gluconic acid and gluconates, glucaric and formic acids, 2-diformylfuran, 2,5-furandicarboxylic acid, maleic acid and anhydride, succinic acid, furanones, furoic acid, alkyl furoates, furan-2-acrolein, succinic acid, butanone and 3-hydroxypropanoic acid. The different mechanistic pathways will be highlighted, as well as the requirements in terms of catalytic sites and catalyst stability. The challenges and opportunities will be put forward for each type of oxidation process.Spanish Ministry of Science, Innovation and Universities (RTI2018-94918) and FEDER (European Union) funds. J. A. C. thanks University of Malaga for contracts of PhD incorporation

Arthroscopic vs. Open-Ankle Arthrodesis on Fusion Rate in Ankle Osteoarthritis Patients: A Systematic Review and Meta-Analysis

Although open surgery is the conventional option for ankle arthritis, there are some reports in the literature regarding the use of the arthroscopy procedure with outstanding results. The primary purpose of this systematic review and meta-analysis was to analyze the effect of the surgery technique (open-ankle arthrodesis vs. arthroscopy) in patients with ankle osteoarthritis. Three electronic databases (PubMed, Web of Science, and Scopus) were searched until 10 April 2023. The Cochrane Collaboration’s risk-of-bias tool was used to assess the risk of bias and grading of the recommendations assessment, development, and evaluation system for each outcome. The between-study variance was estimated using a random-effects model. A total of 13 studies (including n = 994 participants) met the inclusion criteria. The meta-analysis results revealed a nom-significant (p = 0.072) odds ratio (OR) of 0.54 (0.28–1.07) for the fusion rate. Regarding operation time, a non-significant difference (p = 0.573) among both surgical techniques was found (mean differences (MD) = 3.40 min [−11.08 to 17.88]). However, hospital length stay and overall complications revealed significant differences (MD = 2.29 days [0.63 to 3.95], p = 0.017 and OR = 0.47 [0.26 to 0.83], p = 0.016), respectively. Our findings showed a non-statistically significant fusion rate. On the other hand, operation time was similar among both surgical techniques, without significant differences. Nevertheless, lower hospital stay was found in patients that were operated on with arthroscopy. Finally, for the outcome of overall complications, the ankle arthroscopy technique was a protective factor in comparison with open surgery

Implicaciones Fisiológicas en la Vía Aérea Difícil

La Vía Aérea Difícil (VAD) continúa siendo la primera causa de morbi-mortalidad anestésica, e incluye diferentes situaciones, como la ventilación difícil con mascarilla facial (VDMF), laringoscopia difícil (LD), intubación difícil (ID) y la ventilación e intubación imposible (escenario No intubable /No ventilable). Aunque sigue sin existir actualmente en la literatura consenso en la definición de VAD, la ASA define la ID como aquella situación en la que, con la cabeza en posición neutra y con manipulación laríngea externa, la introducción del tubo en la tráquea precisa más de 10 minutos, requiere más de 2-3 intentos, o material accesorio al laringoscopio de Macintosh (1). La VAD representa el 50% de las complicaciones severas en nuestra especialidad, y es responsable de hasta el 30% de las muertes por causa anestésica (2). La mayoría de los casos se deben a la existencia de una VAD no reconocida previamente, de ahí la gran importancia que adquiere la valoración de la vía aérea (VA) en el periodo preoperatorio, y el que todos los especialistas en disposición de manejar la VA de un paciente deban estar correctamente capacitados con las habilidades necesarias para tal fin

Arquitectura por Horas: acciones e interacciones en el espacio colectivo

Presentamos para esta publicación un artículo publicado en inglés e italiano en el año 2012 como “Architetture “Part time”. Azioni e interazioni per lo Spazio Collettivo” (“Architecture “Part time”. Actions and interactions for the collective space”), En Reduce-Recycle- Reuse, Arti performative in spazi urbani. De Vittorio Fiore, Francesca Castagneto, Lettera Ventidue Edicioni . Artículo por tanto, inédito en castellano. La vigencia, tanto de los ejercicios, como de las reflexiones, nos animan a publicarlo en esta ocasión, en su versión en castellano, tal y como fue publicado en los otros idiomas. Los cursos de los que se da cuenta, es la primera experiencia que el conjunto de profesores que la publican, realizaron en Proyectos 1 y Proyectos 2, dos cursos centrados en el proceso de creación, el papel del cuerpo en el proyecto y la construcción de lo real. Las premisas y los ejercicios propuestos (todos centrados en el desarrollo de procesos creativos de corta duración, en la interacción con el espacio urbano, colectivo y social , además de la necesidad impuesta de la ejecución a 1:1 de las propuestas), nos siguen apareciendo vigentes y las acciones trasladables a nuevas experiencias, para aprender, como en el texto expone, no tanto “qué es la arquitectura”, sino lo que en ella acontece.We presented for this publication an article published in English and Italian in 2012 as “Architetture “Part time”. Azioni e interazioni per lo Spazio Collettivo” (“Architecture “Part time”. Actions and interactions for the collective space”), En Reduce-Recycle- Reuse, Arti performative in spazi urbani. By Vittorio Fiore, Francesca Castagneto, Lettera Ventidue Edicioni . Article therefore, unpublished in Spanish. The validity, both of the exercises and of the reflections, encourage us to publish it on this occasion, in its version in Spanish, as it was published in the other languages. The courses of which he realizes, is the first experience that the set of teachers who publish it, carried out in Projects 1 and Projects 2, two courses focused on the creation process, the role of the body in the project and the construction of the real. The premises and the proposed exercises (all focused on the development of short-term creative processes, on interaction with urban, collective and social space, in addition to the imposed need for the implementation at 1:1 of the proposals), follow us appearing and actions transferable to new experiences, to learn, as in the text exposes, not so much “what is architecture”, but what is happening in it

Mapas, rostros y tiempos del grupo de investigación In-Gentes: (Investigación en generación de territorios) en torno a dos áreas temáticas y quince epígrafes para una investigación proyectual.

El presente texto se estructura en torno a dos bloque estratégicos (introducción y cierre) y dos bloque temáticos (barrios y barriadas; creatividad e investigación) en torno a los cueles se ha organizado y gestionado las principales líneas de investigación del grupo de Investigación PAIDI, HUM-958 IN-GENTES (Investigación en Generación de Territorios (anterior TEP238). En el primer apartado se especifican las fases estratégicas que ha atravesado el mismo, desde su creación en el 2007 hasta el momento actual, sirviendo luego de esqueleto para explicitar la investigación realizada en dos campos que emergen con mayor presencia y continuidad: la investigación centrada en la problemática que hemos denominado como “Barrios y barriadas”, en torno a la cual se han estructurado tanto una gran parte de proyectos financiados, como los cursos del departamento con una fuerte componente de investigación (las asignaturas optativas de “Fundamentos de Habitar” del plan 98 y “Arquitectura y sostenibilidad” del plan 2010) y docencia en Master y la línea de investigación matriz de todas ella, “Creatividad e investigación”, en la que se enmarcan las tesis doctorales leídas, gran parte de la investigación paralela a los cursos iniciales de proyectos y la docencia en Doctorado.This paper is structured around two strategic blocks (introduction and closing) and two thematic blocks (slums and neighborhoods; creativity and research) on which PAIDI HUM-958 IN-GENTES (Research in generating of territories) research group investigations have been organized and managed. The first section specifies the strategic phases that the group has experienced since its creation in 2007 until today. This will then be used as the basis for explicit the research carried out in two fields that emerge with a greater presence and continuity. On the one hand, research focused on the issues we have termed “slums and neighborhoods”. The majority of the projects financed; department courses, which have had a strong research component (elective subject of “Fundamentals of inhabit”, belonging to Plan 98, or “Architecture and Sustainability” in Plan 2010); teaching in master and the common parent research line to all of them have been structured around this issue. On the other hand, “creativity and research”, which includes doctoral theses defended, the majority of the parallel research for the initial projects courses and teaching in doctoral program

Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing a proliferation index with ZFtool

Background Zebrafish (Danio rerio) is a model organism that has emerged as a tool for cancer research, cancer being the second most common cause of death after cardiovascular disease for humans in the developed world. Zebrafish is a useful model for xenotransplantation of human cancer cells and toxicity studies of different chemotherapeutic compounds in vivo. Compared to the murine model, the zebrafish model is faster, can be screened using high-throughput methods and has a lower maintenance cost, making it possible and affordable to create personalized therapies. While several methods for cell proliferation determination based on image acquisition and quantification have been developed, some drawbacks still remain. In the xenotransplantation technique, quantification of cellular proliferation in vivo is critical to standardize the process for future preclinical applications of the model. Methods This study improved the conditions of the xenotransplantation technique – quantification of cellular proliferation in vivo was performed through image processing with our ZFtool software and optimization of temperature in order to standardize the process for a future preclinical applications. ZFtool was developed to establish a base threshold that eliminates embryo auto-fluorescence and measures the area of marked cells (GFP) and the intensity of those cells to define a ‘proliferation index’. Results The analysis of tumor cell proliferation at different temperatures (34 °C and 36 °C) in comparison to in vitro cell proliferation provides of a better proliferation rate, achieved as expected at 36°, a maintenance temperature not demonstrated up to now. The mortality of the embryos remained between 5% and 15%. 5- Fluorouracil was tested for 2 days, dissolved in the incubation medium, in order to quantify the reduction of the tumor mass injected. In almost all of the embryos incubated at 36 °C and incubated with 5-Fluorouracil, there was a significant tumor cell reduction compared with the control group. This was not the case at 34 °C. Conclusions Our results demonstrate that the proliferation of the injected cells is better at 36 °C and that this temperature is the most suitable for testing chemotherapeutic drugs like the 5-FluorouracilThis research was funded by the Fondo de Investigación Sanitaria (Instituto Carlos III) - FIS project (PI13/01388). The funding body had no role in the design of the study and collection, analysis, and interpretation of data and in writing of this manuscriptS

Molecular Profiling of Circulating Tumour Cells Identifies Notch1 as a Principal Regulator in Advanced Non-Small Cell Lung Cancer

Knowledge on the molecular mechanisms underlying metastasis colonization in Non-Small Cell Lung Cancer (NSCLC) remains incomplete. A complete overview integrating driver mutations, primary tumour heterogeneity and overt metastasis lacks the dynamic contribution of disseminating metastatic cells due to the inaccessibility to the molecular profiling of Circulating Tumour Cells (CTCs). By combining immunoisolation and whole genome amplification, we performed a global gene expression analysis of EpCAM positive CTCs from advanced NSCLC patients. We identified an EpCAM+ CTC-specific expression profile in NSCLC patients mostly associated with cellular movement, cell adhesion and cell-to-cell signalling mediated by PI3K/AKT, ERK1/2 and NF-kB pathways. NOTCH1 emerged as a driver connecting active signalling pathways, with a reduced number of related candidate genes (NOTCH1, PTP4A3, LGALS3 and ITGB3) being further validated by RT-qPCR on an independent cohort of NSCLC patients. In addition, these markers demonstrated high prognostic value for Progression-Free Survival (PFS). In conclusion, molecular characterization of EpCAM+ CTCs from advanced NSCLC patients provided with highly specific biomarkers with potential applicability as a “liquid biopsy” for monitoring of NSCLC patients and confirmed NOTCH1 as a potential therapeutic target to block lung cancer dissemination.This work was funded by InveNNta (Innovation in Nanomedicine); Operational Programme for Cross-border Cooperation: Spain-Portugal (POCTEP) and European Regional Development Fund (ERDF). Javier Mariscal is recipient of a fellowship from Escola de Doutoramento Internacional Campus Vida of the University of Santiago de Compostela. Laura Muinelo-Romay is supported by ISCIII as Responsible of the Liquid Biopsy Analysis UnitS

Atividade antimicrobiana do óleo-resina de copaíba natural/comercial contra cepas padrão

RESUMO Objetivo: comparar laboratorialmente a atividade antimicrobiana de amostras do óleo-resina de copaíba (Copaifera sp.) natural e comercial sobre as bactérias Pseudomonas aeruginosa ATCC 9027, Escherichia coli ATCC 25922 e Staphylococcus aureus ATCC 25923. Método: Trata-se de um estudo transversal descritivo ao qual utilizou-se a técnica de cilindro em placa além da determinação da concentração inibitória mínima do óleo em ágar Mueller-Hinton. Para o controle positivo foi utilizado solução de Hidróxido de Sódio e para o controle negativo, solução fisiológica de Cloreto de Sódio. Resultados: o óleo de copaíba natural e comercial apresentou potencial de inibição do crescimento bacteriano satisfatório sobre as cepas Staphylococcus aureus ATCC 25923 e Escherichia coli ATCC 25922, sendo a bactéria Pseudomonas aeruginosa ATCC 9027 resistente ao óleo na concentração de 150µL da solução. A atividade antimicrobiana variou de acordo com os óleos e os patógenos estudados; nas concentrações de 100% até 3,1% houve inibição da cepa Escherichia coli ATCC 25922 e de 100% a 25% da cepa Staphylococcus aureus ATCC 25923, em ambos os óleos de copaíba. Conclusão: o óleo de copaíba natural e comercial possuem diferenças mínimas no potencial de inibição para os específicos patógenos. No entanto, Escherichia coli ATCC 25922 foi mais sensível que Staphylococcus aureus ATCC 25923, tanto no óleo-resina natural quanto comercial. ABSTRACT Objective: to compare the antimicrobial activity of natural and commercial copaíba (Copaifera sp.) oil-resin samples on the bacterias Pseudomonas aeruginosa ATCC 9027, Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923. Method: this is a descriptive cross-sectional study analysis to which the plate cylinder technique was used in addition to the determination of the minimum inhibitory concentration of the oil in Mueller-Hinton agar. For the positive control it was used a sodium hydroxide solution and for the negative control, a physiological sodium chloride solution. Results: commercial and natural copaiba oil showed satisfactory bacterial growth inhibition on Staphylococcus aureus strains ATCC 25923 and Escherichia coli ATCC 25922, with the bacterium Pseudomonas aeruginosa ATCC 9027 being resistant to oil in the concentration of 150 μL of the solution. The antimicrobial activity varied according to the oils and pathogens studied; at concentrations of 100% to 3.1% there was inhibition of the Escherichia coli strain ATCC 25922 and 100% to 25% of Staphylococcus aureus strain ATCC 25923 in both copaiba oils. Conclusion: natural and commercial copaiba oil have minimal differences in the potential for inhibition of specific pathogens. However, Escherichia coli ATCC 25922 was more sensitive than Staphylococcus aureus ATCC 25923, both in the natural and commercial oil-resin