The Piano Music of Maurice Ohana

A composer whose first works date from his early thirties and whose first important, large-scale composition does not appear until the age of thirty-seven could well be perceived as a late starter. This to some extent was the case with Maurice Ohana. The earliest works which he allowed to remain in his catalogue were composed towards the end of the Second World War when, taking advantage of his army posting to Italy, he enrolled in the piano class of Alfredo Casella at the Academia Santa Cecilia in Rome. Although he established his compositional presence later than most others belonging to that illustrious generation of composers born in and around 1913, it would be misleading to suggest that Ohana either came to music late in life or was to any extent a late developer. His real beginnings as a composer were delayed not only by the Second World War, but by the success of his first career as a concert pianist which he pursued throughout the 1930s and for some time after his war service. It is not surprising, therefore, that music for his own instrument, the piano, should figure prominently in Ohanas catalogue. Indeed, much of his compositional development is reflected through his work in this medium, his music for solo piano spanning almost all of his creative years from the mid 1940s to the mid 1980s

Pyruvate Carboxylation in Different Model Systems Studied by 13C MRS

Pyruvate carboxylation is of great importance in the brain since it is responsible for adding net carbons to the tricarboxylic acid cycle following removal of carbon backbone for synthesis of the two most abundant neurotransmitters, glutamate and GABA. Despite having such a pivotal role, there is still much uncertainty in the exact metabolic details about where and how this carbon is returned. Pyruvate carboxylation has been studied in various model systems of the brain and 13C magnetic resonance spectroscopy is an excellent tool for doing this. This review will focus on results dealing with the extent and cellular location of pyruvate carboxylation and its role in pathophysiology and concludes that pyruvate carboxylation is an extraordinarily important predominantly astrocytic pathway which plays a pivotal part in a number of diseases

Maurice Ohana’s 'Office des Oracles' and 'Messe' [Music Review]

This article compares two major vocal works by French composer Maurice Ohana composed during the 1970s and sets them in context within twentieth century French music

Henri Dutilleux and Maurice Ohana: victims of an exclusion zone?

Until recently, the music of Henri Dutilleux and Maurice Ohana was largely overlooked in Britain, despite both composers having achieved widespread recognition beyond our shores. In France they have ranked among the leading composers of their generation since at least the 1960s and have received many of the highest official accolades. In Britain, the view of French music since 1945 has often been synonymous with the music of Olivier Messiaen and Pierre Boulez, to the virtual exclusion of others whose work has long been honoured not only in France and elsewhere in Europe but in the wider international arena. These ‘others’ include Dutilleux and Ohana. Developing an innovative and forward-looking approach, independent from the preoccupations of their contemporaries who congregated at Darmstadt, both Dutilleux and Ohana were excluded from representation at the concerts of the Domaine musical. As a result, their music was neglected in Britain throughout the years when the programming policies of Boulez and Sir William Glock were at their most influential. Undoubtedly, Boulez is one of the most phenomenal figures in music of the last 50 or so years and the position of his erstwhile teacher Messiaen is secure as one of the giants of the 20th century. Yet, however significant their respective contribution, Boulez and Messiaen represent only one facet of French music since 1945

Increased permeability of the malaria-infected erythrocyte to organic cations

AbstractThe human malaria parasite, Plasmodium falciparum, induces in the plasma membrane of its host red blood cell new permeation pathways (NPP) that allow the influx of a variety of low molecular weight solutes. In this study we have demonstrated that the NPP confer upon the parasitised erythrocyte a substantial permeability to a range of monovalent organic (quaternary ammonium) cations, the largest having an estimated minimum cross-sectional diameter of 11–12 Å. The rate of permeation of these cations showed a marked dependence on the nature of the anion present, increasing with the lyotropicity of the anion. There was no clear relationship between the permeation rate and either the size or the hydrophobicity of these solutes. However, the data were consistent with the rate of permeation being influenced by a combination of these two factors, with the pathways showing a marked preference for the relatively small and hydrophobic phenyltrimethylammonium ion over larger or less hydrophobic solutes. Large quaternary ammonium cations inhibited flux via the NPP, as did long-chain n-alkanols. For both classes of compound the inhibitory potency increased with the size and hydrophobicity of the solute. This study extends the range of solutes known to permeate the NPP of malaria-infected erythrocytes as well as providing some insight into the factors governing the rate of permeation

Investigating the hydration of C3A in the presence of the potentially toxic element chromium–a route to remediation?

Pollution by hexavalent chromium is a growing, global problem. Its presence in public water systems is often the result of industrial activities, both past and present. In this study, tricalcium aluminate (C3A, Ca(3)Al(2)O(6)) is added to solutions of varying concentrations of potassium chromate (K(2)CrO(4)) and samples of both the solid and liquid are taken at various time intervals to monitor the removal of chromium from the solutions. Solution concentrations of 0.2 M, 0.1 M, 0.02 M, and 0.01 M are used, and the chromium concentration is found to reduce in all cases. For the 0.02 M solution the chromium concentration is reduced from 1040 ppm to 3.1 ppm in 1 week, and the chromium concentration of the 0.01 M solution is reduced from 520 ppm to 0.26 ppm in only one day of reaction with the C3A. The chromium removed from solution is identified in the solid products, which were fully characterised as being a mixture of ettringite (Ca(6)[Al(OH)(6)](2)(CrO(4))(3)·26H(2)O) and monochromate (Ca(4)[Al(OH)(6)](2)CrO(4)·8H(2)O) phases from analysis of Powder X-ray Diffraction and Fourier Transform Infrared Spectroscopy data. The work presented here is a proof of concept study to investigate C3A as a potential material for the removal of hexavalent chromium from solution. The results from this study are initial steps towards development of this as a technology for hexavalent chromium remediation

Retrospective cohort study of the South Tyneside Exercise Referral scheme 2009-2014: Predictors of dropout and barriers to adherence

Background: Exercise Referral Schemes (ERS) are a prevalent method of increasing physical activity levels. However, they suffer from participant dropout and research predicting dropout or barriers to adherence is limited. This study aimed to focus upon the effect of referral characteristics on dropout, dropout predictors and whether self-reported barriers to exercise predict dropout. Methods: ERS data from 2009-2014 were retrieved for analysis. Chi squared and t-tests were used to investigate differences between referral characteristics, and logistic regression used to investigate dropout predictors. Results: Of 6894 participants, 37.8% (n=2608) dropped out within 6 weeks and 50.03% (n=3449) by the final 12th week. More males adhered (p<0.001) with dropouts being significantly younger (p<0.001). Dropout predictors were smoking (OR=1.58, 95% CI:1.29-1.93) or being a Tier 3 referral (OR=1.47, 95% CI:1.25-1.73). Increasing age (OR=0.98, 95% CI:0.98-0.99), drinking alcohol (OR=0.82, 95% CI:0.71-0.95), secondary care referrals (OR=0.68, 95% CI:0.52-0.90), having a lack of motivation (OR=0.81, 95% CI:0.69-0.95), or a lack of childcare (OR=0.69, 95% CI:0.50-0.95) decreased the likelihood of dropout. Conclusion: ERS dropout continues to be problematic. Smoking and having moderate-high comorbidities predicted dropout. Increasing age and patient-reported barriers of a lack of time or childcare decreased dropout risk. The reasons for dropout require further investigation

Attitudes, beliefs, behaviours and perspectives on barriers and enablers of Australian general practitioners towards non-drug interventions: A national survey

BACKGROUND: Many guidelines recommend non-drug interventions (NDIs) for managing common conditions in primary care. However, compared with drug interventions, NDIs are less widely known, promoted and used. We aim to (1) examine general practitioners' (GPs') knowledge, attitudes and practices for NDIs, including their use of the Royal Australian College of General Practitioners (RACGP) Handbook of Non-Drug Interventions (HANDI), and (2) identify factors influencing their use of NDIs and HANDI.METHODS: We conducted a web-based cross-sectional survey of practicing GP members in Australia during October-November 2022. The survey contained five sections: characteristics of GP; knowledge and use of NDIs; attitudes towards NDIs; barriers and enablers to using HANDI; and suggestions of NDIs and ideas to improve the uptake of NDIs in primary care.RESULTS: Of the 366 GPs who completed the survey, 242 (66%) were female, and 248 (74%) were ≥45 years old. One in three GPs reported that they regularly ('always') recommend NDIs to their patients when appropriate (34%), whereas one-third of GPs were unaware of HANDI (39%). GPs identified several factors that improve the uptake of HANDI, including 'access and integration of HANDI in clinical practice', 'content and support to use in practice' and 'awareness and training'.CONCLUSIONS: While many GPs are aware of the effectiveness of NDIs and often endorse their use, obstacles still prevent widespread adoption in primary care. The results of this survey can serve as a foundation for developing implementation strategies to improve the uptake of effective evidence-based NDIs in primary care.</p