Calculation of magnetic anisotropy energy in SmCo5

SmCo5 is an important hard magnetic material, due to its large magnetic anisotropy energy (MAE). We have studied the magnetic properties of SmCo5 using density functional theory (DFT) calculations where the Sm f-bands, which are difficult to include in DFT calculations, have been treated within the LDA+U formalism. The large MAE comes mostly from the Sm f-shell anisotropy, stemming from an interplay between the crystal field and the spin-orbit coupling. We found that both are of similar strengths, unlike some other Sm compounds, leading to a partial quenching of the orbital moment (f-states cannot be described as either pure lattice harmonics or pure complex harmonics), an optimal situation for enhanced MAE. A smaller portion of the MAE can be associated with the Co-d band anisotropy, related to the peak in the density of states at the Fermi energy. Our result for the MAE of SmCo5, 21.6 meV/f.u., agrees reasonably with the experimental value of 13-16 meV/f.u., and the calculated magnetic moment (including the orbital component) of 9.4 mu_B agrees with the experimental value of 8.9 mu_B.Comment: Submitted to Phys. Rev.

3p photoabsorption spectra of Mn2+ and Mn3+

Time resolved EUV photoabsorption spectra of a manganese plasma have been recorded using the dual laser plasma technique. The 43 - 73 eV photon energy range is dominated by the 3p-3d giant resonance and to a lesser extent the 3p-4s resonances in both Mn2+ and Mn3+, recorded at an interplasma time delay of 80 ns and 30 ns respectively. These experimentally observed resonances are well reproduced by synthetic spectra calculated using the Hartree-Fock method. The synthetic spectra allow for absorption from excited states of the Mn2+ and Mn3+ ions

The Grizzly, May 2, 1986

Student Health Center • Musser Renovation Hatches U.C. Experiment in International Living • Maintenance Men Injured in Electrical Accident • Letters: Toilet Paper Article Belongs in the Toilet, not the Paper; Theatres Filthy • Schultz and Fletcher Retire After Long Ursinus Careers • Farewell Seniors • The Salinger Myth • Women\u27s Lacrosse Awaits NCAA Bid • Cornbone\u27s Curtain Call • U.C. Hosts MAC\u27s • Men\u27s Lax Ends at .500 • Ursinus Athletic Complex Reigns Supreme in Division III • Profile: Abe Rowson • Goodwin: A Bright Light in the Future of Ursinus Basketball • Costs and Past Vandalism Thwart U.C.\u27s Hosting Big Rock Bands • Briefs: Bear Pit; Happy Hour; Evening School; Radio; Education; Randolphhttps://digitalcommons.ursinus.edu/grizzlynews/1165/thumbnail.jp

The Grizzly, March 20, 1987

Pledging Population Plummets • Resident Fulbright Scholar to Lecture on Latin America • Board Makes Promotions • Letter: Help is on the Way Writes Jamison • Upcoming Meistersinger and Chamber Singer Concert • Our Town Student Actor Profiles • Senior Symp. Surges Ahead • Women\u27s Lax Set to Defend Title on Wednesday • Bear Baseball Rides 5-1 Florida Trip into Collegeville • Track Opens • Young Softball Team Begins New Season •Swimmin\u27 Women Medal Winners • Infant Women\u27s Running Program Soars Over the MAC • Former Olympic Player to Fill Soccer Assistant Slot •Sieracki Steps Down after Seven Years • Deep Purple Releases Blue Light LPhttps://digitalcommons.ursinus.edu/grizzlynews/1185/thumbnail.jp

Enhancement of Cardiac Store Operated Calcium Entry (SOCE) within Novel Intercalated Disk Microdomains in Arrhythmic Disease

Store-operated Ca2+ entry (SOCE), a major Ca2+ signaling mechanism in non-myocyte cells, has recently emerged as a component of Ca2+ signaling in cardiac myocytes. Though it has been reported to play a role in cardiac arrhythmias and to be upregulated in cardiac disease, little is known about the fundamental properties of cardiac SOCE, its structural underpinnings or effector targets. An even greater question is how SOCE interacts with canonical excitation-contraction coupling (ECC). We undertook a multiscale structural and functional investigation of SOCE in cardiac myocytes from healthy mice (wild type; WT) and from a genetic murine model of arrhythmic disease (catecholaminergic ventricular tachycardia; CPVT). Here we provide the first demonstration of local, transient Ca2+ entry (LoCE) events, which comprise cardiac SOCE. Although infrequent in WT myocytes, LoCEs occurred with greater frequency and amplitude in CPVT myocytes. CPVT myocytes also evidenced characteristic arrhythmogenic spontaneous Ca2+ waves under cholinergic stress, which were effectively prevented by SOCE inhibition. In a surprising finding, we report that both LoCEs and their underlying protein machinery are concentrated at the intercalated disk (ID). Therefore, localization of cardiac SOCE in the ID compartment has important implications for SOCE-mediated signaling, arrhythmogenesis and intercellular mechanical and electrical coupling in health and disease

The Grizzly, March 27, 1987

Vandals Violate Student Property • Greek Week • Comprehensive Conflicts • Letter: Brothers Give Thanks • Future Changes for Ursinus • English Comprehensive Anxieties • Table Talk • Students Should Become Aware of Career Aid Opportunities • Lent, Wood Lead Ursinus at ECAC\u27s • Men\u27s Outdoor Track Upsets F&M • Lacrosse Opens Defense of National Crown • Golfers Win • Men Netters Split • Women\u27s Tennis Upsets Widener • Bears Leave Del. Val. Blue • Wentzel, Nelson Shut Down Widener • Wrestlers Lauded for Academics • O\u27Donohue Runs to All-American • WVOU Makes Waves • Hall Highlights Women\u27s Studies • Notes: Cub & Key Add Junior Members; Forum on Ethnic Writers; Richter Lectures to Community • The Bear Facts • Flamin\u27 Caucasians to Rock Ursinus • CAB Comedy Night a Laugh • Ursinus Receives Educational Grant • College Choir to Perform Elijahhttps://digitalcommons.ursinus.edu/grizzlynews/1186/thumbnail.jp

The Grizzly, May 3, 1985

Reimert Hall Will Welcome Girls in the Fall • Fraternities Are Still Alive at Ursinus • Ursinus Applicants Improve • Letters: Greek Week Disappointing; Radio Offers Thanks • Drinking Age of 21 Should Not Be a Standard • Profile: Dr. Coggers Says Farewell • Greek Week\u27s Final Results • Lacrosse Looks to Repeat Division III Title • Successful Year for Lacrosse Club • Gasser Retires • Sally Grim Shines As Star Pitcher • Griffin Worth Far More than Gold • Trackmen Head to MAC\u27s • Stormy Baver is Pilot Behind the Plate • Golf Team Optimistic • Visit the Writing Center • 1985 Baseball Wraps it Up • 1985 Lacrosse Stats • St. Joseph\u27s M.B.A Courses Offered at Ursinus • Open Dialog On Intervention • Area Residents Share College Memories • Shorts: Faculty Members to Retire; Open Dialog; Color Analysis Held on Campus; Evening Concert Announced; Voices ; Art Show • Dead Kennedys • WVOU Conducts Survey • Luau on Sat. • Weekend Highlights • It Will Be a Fantasy Weekendhttps://digitalcommons.ursinus.edu/grizzlynews/1142/thumbnail.jp

The Grizzly, May 1, 1987

Will Ursinus Make the Grade? • Commuters Recognized • Student Apathy a Farce • Beatles Now Available on Disc • Dougy is King to Sig Rho • Notes: Summer Tennis Strategies Offered; Continuing Ed. Becomes Assertive; Physical Education Day: May 4th; Band and Jazz Ensemble to Perform • Lacrosse Shoots for 4th Title; Bingaman Breaks Another Record • MAC\u27s Return to Ursinus; Bears Look to Usurp Crown • Golf Ties Record at 15-1: Klee, Ignatowicz Lead Bears to MAC Fifth • Trout Tourney Results • The Men Looking For Glory • Baseball Season Ends on Down Note • Kulp Driven to Excellence • Softball Denied Playoffs • Women Netters .500 • Dolman Leaves with Warm Feelings • Renovations at Myrin • Zucker Retires to Further Musical Interests • Multi-talented Symons Ends Forty Year Career at Ursinus • Page Closes the Book at Ursinushttps://digitalcommons.ursinus.edu/grizzlynews/1189/thumbnail.jp

Employing Dietary Comparators to Perform Risk Assessments for Anti-Androgens Without Using Animal Data

This study investigated the use of androgen receptor (AR) reporter gene assay data in a non-animal exposure-led risk assessment in which in vitro anti-androgenic activity and exposure data were put into context using a naturally occurring comparator substance with a history of dietary consumption. First, several dietary components were screened to identify which selectively interfered with AR signaling in vitro, using the AR CALUX® test. The IC50 values from these dose-response data together with measured or predicted human exposure levels were used to calculate exposure:activity ratios (EARs) for the dietary components and a number of other well-known anti-androgenic substances. Both diindolylmethane (DIM) and resveratrol are specifically-acting dietary anti-androgens. The EARs for several anti-androgens were therefore expressed relative to the EAR of DIM, and how this ‘dietary comparator ratio’ (DCR) approach may be used to make safety decisions was assessed using an exposure-led case study for an anti-androgenic botanical ingredient. This highlights a pragmatic approach which allows novel chemical exposures to be put into context against dietary exposures to natural anti-androgenic substances. The DCR approach may have utility for other modes of action where appropriate comparators can be identified