Time Multiplexed Active Neural Probe with 678 Parallel Recording Sites

We present a high density CMOS neural probe with active electrodes (pixels), consisting of dedicated in-situ circuits for signal source amplification. The complete probe contains 1356 neuron size (20x20 μm2) pixels densely packed on a 50 μm thick, 100 μm wide and 8 mm long shank. It allows simultaneous highperformance recording from 678 electrodes and a possibility to simultaneously observe all of the 1356 electrodes with increased noise. This considerably surpasses the state of the art active neural probes in electrode count and flexibility. The measured action potential band noise is 12.4 μVrms, with just 3 μW power dissipation per electrode amplifier and 45 μW per channel (including data transmission)

Time Multiplexed Active Neural Probe with 1356 Parallel Recording Sites

We present a high electrode density and high channel count CMOS (complementary metal-oxide-semiconductor) active neural probe containing 1344 neuron sized recording pixels (20 µm × 20 µm) and 12 reference pixels (20 µm × 80 µm), densely packed on a 50 µm thick, 100 µm wide, and 8 mm long shank. The active electrodes or pixels consist of dedicated in-situ circuits for signal source amplification, which are directly located under each electrode. The probe supports the simultaneous recording of all 1356 electrodes with sufficient signal to noise ratio for typical neuroscience applications. For enhanced performance, further noise reduction can be achieved while using half of the electrodes (678). Both of these numbers considerably surpass the state-of-the art active neural probes in both electrode count and number of recording channels. The measured input referred noise in the action potential band is 12.4 µVrms, while using 678 electrodes, with just 3 µW power dissipation per pixel and 45 µW per read-out channel (including data transmission)

An artificial iris ASIC with high voltage liquid crystal driver, 10 nA light range detector and 40 nA blink detector for LCD flicker removal

In a normally functioning eye, the iris controls the pupil diameter to regulate the amount of light reaching the retina. Various iris deficiencies exist, manifesting as defects in the iris or an absence of one which result in too much light reaching the retina. Some iris deficiencies, such as aniridia or leiomyoma, can be mitigated with fixed or adaptive artificial irises. As an alternative, adaptive transparency glasses may also alleviate this situation, however, both solutions do not mimic the other normal functionality of the natural iris: adaptive aperture. To address this, we developed a fully encapsulated, self-contained artificial iris embedded in a smart contact lens. The control ASIC of the contact lens is developed in 0.18-μm 16-V BCD TSMC and has a typical power consumption of 1.9 μW from a 3-V supply voltage at office light condition

Time multiplexed active neural probe with 678 parallel recording sites

We present a high density CMOS neural probe with active electrodes (pixels), consisting of dedicated in-situ circuits for signal source amplification. The complete probe contains 1356 neuron sized (20×20 μm2) pixels densely packed on a 50 μm thick, 100 μm wide and 8 mm long shank. It allows simultaneous high-performance recording from 678 electrodes and a possibility to simultaneously observe all of the 1356 electrodes with increased noise. This considerably surpasses the state of the art active neural probes in electrode count and flexibility. The measured action potential band noise is 12.4 μVrms, with just 3 μW power dissipation per electrode amplifier and 45 μW per channel (including data transmission)