H19 and IGF-2 allele-specific expression in hepatoblastoma

Patterns of allele-specific expression of H19 and insulin-like growth factor-2 (IGF-2) were examined in tissue obtained from 30 children diagnosed with hepatoblastoma. All informative tumours demonstrated monoallelic expression of H19. In contrast, variable patterns of allele-specific expression of IGF-2 were seen in tumours from children of different ages.© 2000 Cancer Research Campaig

Improving Caregivers’ Confidence with the Powerful Tools for Caregivers Program

The Powerful Tools for Caregivers (PTC) program is designed to help caregivers develop skills to improve their self-efficacy in caregiving. To demonstrate the effectiveness of the PTC program in Boise, Idaho, the program’s pre-survey (n = 277), end-of-program survey (n = 131), and 6-month follow-up post-survey data (n = 100) collected between 2011 and 2017 were analyzed in this study. The end-of-program survey data indicated that caregivers viewed the quality of the program to be excellent and that all of them felt more confident as a caregiver. Factor analysis and reliability testing on the pre-survey data confirmed that seven questions included in the pre- and 6-month follow-up post-survey instruments reliably measured a single factor named as caregiver confidence. A paired samples t-test on 76 complete sets of pre- and 6-month follow-up post-survey data on the seven questions revealed that caregivers improved their confidence in caregiving to a statistically significant level (p \u3c .001, d = 45). Additional paired samples t-tests on each of the seven questions with the Bonferroni correction showed statistically significant improvements in three areas: Making tough decisions (p \u3c .001, d = .53), coping with emotions (p \u3c .001, d = .54), and using stress-reducing activities (p \u3c.007, d = .33). Caregivers experienced the greatest improvement in their confidence in making tough decisions. Despite these significant improvements, caregivers still struggled with finding ways to reduce stress and manage their emotions associated with caregiving as shown by the lowest pre- and 6-month follow-up post-survey scores. In addition to the study results, several considerations when synthesizing PTC research results are discussed

Determinants of student satisfaction with campus residence life at a South African University

Although there are a number of studies on the determinants of general quality of life among university students, these occur mainly in developed countries and do not focus specifically on campus-based residence life. It has long been accepted that factors outside the classroom (“the other curriculum”) can contribute to academic success, as well as the achievement of other important outcomes such as the appreciation of human diversity. Striving towards equality of residence life satisfaction across different racial and gender groups, for example, is thus important for academic outcomes and for the development of well-functioning citizens. This study is based on the 2011 Quality of Residence Life (QoRL) Survey, conducted at a South African university, comprising roughly 2 000 respondents. Based on descriptive analyses and ordered probit regressions, the study investigates the association between satisfaction with QoRL and (i) residence milieu and characteristics, (ii) direct and indirect discrimination, (iii) perceptions of drug and alcohol issues in residence, (iv) safety, and (v) individual student characteristics. One of the main findings is that there are no significant differences in satisfaction with QoRL across racial and gender groups; a finding that suggests significant progress in university transformation and equity goals. The general atmosphere and characteristics of residences are also important predictors of QoRL satisfaction.Economic Research Southern Africa (ERSA) is a research programme funded by the National Treasury of South Africa

Rehabilitation Intervention for Individuals With Heart Failure and Fatigue to Reduce Fatigue Impact: A Feasibility Study

Objective: To investigate feasibility of recruitment, tablet use in intervention delivery, and use of self-report outcome measures and to analyze the effect of Energy Conservation plus Problem-Solving Therapy versus Health Education interventions for individuals with heart failure-associated fatigue. Methods: This feasibility study was a block-randomized controlled trial involving 23 adults, blinded to their group assignment, in a rural southern area in the United States. Individuals with heart failure and fatigue received the interventions for 6 weeks through videoconferencing or telephone. Participants were taught to solve their fatigue-related problems using energy conservation strategies and the process of Problem-Solving Therapy or educated about health-related topics. Results: The recruitment rate was 23%. All participants completed the study participation according to their group assignment, except for one participant in the Energy Conservation plus Problem-Solving Therapy group. Participants primarily used the tablet (n=21) rather than the phone (n=2). Self-report errors were noted on Activity Card Sort (n=23). Reported fatigue was significantly lower for both the Energy Conservation plus Problem-Solving Therapy (p=0.03, r=0.49) and Health Education (p=0.004, r=0.64) groups. The Health Education group reported significantly lower fatigue impact (p=0.019, r=0.48). Participation was significantly different in low-physical demand leisure activities (p=0.008; r=0.55) favoring the Energy Conservation plus Problem-Solving Therapy group. Conclusion: The recruitment and delivery of the interventions were feasible. Activity Card Sort may not be appropriate for this study population due to recall bias. The interventions warrant future research to reduce fatigue and decrease participation in sedentary activities (Clinical Trial Registration number: NCT03820674)

Social parasitism by honeybee workers (Apis mellifera capensis Escholtz): host finding and resistance of hybrid host colonies

We studied possible host finding and resistance mechanisms of host colonies in the context of social parasitism by Cape honeybee (Apis mellifera capensis) workers. Workers often join neighboring colonies by drifting, but long-range drifting (dispersal) to colonies far away from the maternal nests also rarely occurs. We tested the impact of queenstate and taxon of mother and host colonies on drifting and dispersing of workers and on the hosting of these workers in A. m. capensis, A. m. scutellata, and their natural hybrids. Workers were paint-marked according to colony and reintroduced into their queenright or queenless mother colonies. After 10 days, 579 out of 12,034 labeled workers were recaptured in foreign colonies. We found that drifting and dispersing represent different behaviors, which were differently affected by taxon and queenstate of both mother and host colonies. Hybrid workers drifted more often than A. m. capensis and A. m. scutellata. However, A. m. capensis workers dispersed more often than A. m. scutellata and the hybrids combined, and A. m. scutellata workers also dispersed more frequently than the hybrids. Dispersers from queenright A. m. capensis colonies were more often found in queenless host colonies and vice versa, indicating active host searching and/or a queenstate-discriminating guarding mechanism. Our data show that A. m. capensis workers disperse significantly more often than other races of A. mellifera, suggesting that dispersing represents a host finding mechanism. The lack of dispersal in hybrids and different hosting mechanisms of foreign workers by hybrid colonies may also be responsible for the stability of the natural hybrid zone between A. m. capensis and A. m. scutellata

Students perceiving risk: a quantitative assessment on three South African university campuses

This paper documents risk as perceived by students in three South African universities—it focuses on risk encountered in everyday choices such as sexual behaviour, alcohol use and freedom of association.The project originated in qualitative research conducted over two years (2008- 2009) among Rhodes University (RU) Sociology students. A second—quantitative—phase began in 2010 when findings from the initial phase were used to guide students in designing and piloting a questionnaire. Pilot results then informed a final research iteration in which a second questionnaire was designed and administered at three universities.The final questionnaire proved robust and performed very well. Among the 1694 valid cases included in analyses, strong associations were found between the universities, respondents’ sex and their worldview. Exploratory factor analysis revealed four latent constructs underlying all responses: The existential experience of risk; Stress and pressure resulting from exposure to financial and emotional risk; Risks attached to the everyday university culture; and Promiscuity. These constructs explained 59.8% of the total variance in all observed cases (all respondents in all universities).Students’ perception of risk in their lives is complex and multi-dimensional. The research found considerable evidence for Beck’s claim that in late modernity there is increasing individualisation in people’s perception of risk. Also, the degrees to which specific risks resonate in student consciousness demonstrate that risk is—as Zinn claims—both constructed and real.Key Words: risk, student behaviour, existential experience, sexual violence, South AfricaRésuméCet article documente le risque perçu par les étudiants dans trois universités sud- africaines concentre-il un risque rencontré dans les choix de tous les jours tels que le comportement sexuel, la consommation d’alcool et la liberté de projet association. The origine dans la recherche qualitative Menée sur deux ans (2008-2009) entre Les étudiants de l’Université de Rhodes (RU) sociologie. Une deuxième phase quantitative a commencé en 2010 lorsque les résultats de la première phase ont été utilisés pour guider les élèves dans la conception et le pilotage d’un questionnaire. Résultats de pilote informe alors une itération de recherche final dans lequel un second questionnaire a été conçu et administré à trois universities.The questionnaire final s’est avéré robuste et très bien performé. Parmi les 1 694 cas valides incluses dans les analyses, de fortes associations ont été trouvées entre les universités, le sexe des répondants et de leur vision du monde. L’analyse factorielle exploratoire a révélé quatre construits latents sous-jacents toutes les réponses: L’expérience existentielle de risque; Le stress et la pression résultant de l’exposition au risque financier et émotionnel; Risques liés à la culture universitaire de tous les jours; et la promiscuité. Ces constructions ont expliqué 59,8% de la variance totale dans tous les-cas observés (tous les répondants dans toutes les universités). La perception du risque dans leur vie des étudiants est complexe et multidimensionnelle. La recherche a trouvé des preuves considérables pour la demande de Beck C’est à la fin de la modernité, il ya augmentation de l’individualisation dans la perception des gens de risque. En outre, les degrés dans laquelle les risques spécifiques résonnent dans la conscience des étudiants démontrent C’est le risque que les créances Zinn appliquées Bothan- construit et réel.Mots clés: risque, le comportement des élèves, l’expérience existentielle, la violence sexuelle, l’Afrique du Su

HIV Testing and Conspiracy Beliefs Regarding the Origins of HIV among African Americans

Abstract Conspiracy beliefs regarding the origins of HIV are common among African Americans, and have been associated with engaging in HIV risk behaviors but also with earlier diagnosis among HIV patients. The objective of the present study was to test the association of HIV serostatus testing with conspiracy beliefs. A total of 1430 African Americans from low-income neighborhoods with high rates of drug use were surveyed in 1997-1999 in face-to-face interviews. Two 4-point items assessed if participants agreed that AIDS was started by an experiment that went wrong and AIDS was created to kill blacks and poor folks. A binary variable indicated if the respondent agreed with the statements, on average. 22.5% of the sample endorsed conspiracy beliefs, 4.0% of whom reported not having had an HIV test, compared to 7.7% of those who did not endorse conspiracy beliefs. In multivariable logistic regression modeling, never having had an HIV test was significantly associated with conspiracy beliefs (adjusted odds ratio [AOR]=0.43, 95% confidence interval [CI]=1.3-4.3), having a high school education (AOR=0.55, CI=0.35-0.84), having depression (AOR=1.61, CI=1.02-2.52), female gender (AOR=0.54, CI=0.34-0.86), younger age, and a history of injection drug use (AOR=0.36, CI=0.23-0.56), but not sex risk behaviors (multiple partners, irregular condom use). The finding that individuals who have conspiracy beliefs are more likely to have been tested for HIV may partially explain why HIV-positive individuals who endorse conspiracy beliefs are more likely to obtain an earlier diagnosis.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78123/1/apc.2009.0061.pd

Missed opportunities for family planning counselling among postpartum women in eleven counties in Kenya

Background: Mothers may access medical facilities for their babies and miss opportunities to access family planning (FP) services. This study was undertaken to describe missed opportunities for FP among women within the extended (0–11months) postpartum period from counties participating in Performance Monitoring and Accountability 2020 (PMA2020) surveys. Design and setting: This study analysed cross-sectional household survey data from 11 counties in Kenya between 2014 and 2018. PMA2020 uses questions extracted from the Demographic and Health survey (DHS) and DHS defnitions were used. Multivariable logistic regression was used for inferential statistics with p-value of \u3c0.05 considered to be signifcant. Participants: Women aged 15-49 years from the households visited. Primary outcome measure: Missed opportunity for family planning/contraceptives (FP/C) counselling. Results: Of the 34,832 women aged 15-49 years interviewed, 10.9% (3803) and 10.8% (3746) were in the period 0–11months and 12–23months postpartum respectively, of whom, 38.8 and 39.6% respectively had their previous pregnancy unintended. Overall, 50.4% of women 0-23months postpartum had missed opportunities for FP/C counselling. Among women who had contact with health care at the facility, 39.2% of women 0-11months and 44.7% of women 12-23months had missed opportunities for FP/C counselling. Less than half of the women 0-11months postpartum (46.5%) and 64.5% of women 12 – 23months postpartum were using highly efcacious methods. About 27 and 18% of the women 0-11months and 12 – 23months postpartum respectively had unmet need for FP/C. Multivariable analysis showed that being low parity and being from the low wealth quintile signifcantly increased the odds of missed opportunities for FP/C counselling among women in the extended postpartum period, p\u3c0.05. Conclusions: A large proportion of women have missed opportunities for FP/C counselling within 2 years postpartum. Programs should address these missed opportunities

Self-rated health in middle-aged and elderly Chinese : distribution, determinants and associations with cardio-metabolic risk factors

Background: Self-rated health (SRH) has been demonstrated to be an accurate reflection of a person's health and a valid predictor of incident mortality and chronic morbidity. We aimed to evaluate the distribution and factors associated with SRH and its association with biomarkers of cardio-metabolic diseases among middle-aged and elderly Chinese. Methods: Survey of 1,458 men and 1,831 women aged 50 to 70 years, conducted in one urban and two rural areas of Beijing and Shanghai in 2005. SRH status was measured and categorized as good (very good and good) vs. not good (fair, poor and very poor). Determinants of SRH and associations with biomarkers of cardio-metabolic diseases were evaluated using logistic regression. Results: Thirty two percent of participants reported good SRH. Males and rural residents tended to report good SRH. After adjusting for potential confounders, residence, physical activity, employment status, sleep quality and presence of diabetes, cardiovascular disease, and depression were the main determinants of SRH. Those free from cardiovascular disease (OR 3.68; 95%CI 2.39; 5.66), rural residents (OR 1.89; 95% CI 1.47; 2.43), non-depressed participants (OR 2.50; 95% CI 1.67; 3.73) and those with good sleep quality (OR 2.95; 95% CI 2.22; 3.91) had almost twice or over the chance of reporting good SRH compared to their counterparts. There were significant associations -and trend- between SRH and levels of inflammatory markers, insulin levels and insulin resistance. Conclusion: Only one third of middle-aged and elderly Chinese assessed their health status as good or very good. Although further longitudinal studies are required to confirm our findings, interventions targeting social inequalities, lifestyle patterns might not only contribute to prevent chronic morbidity but as well to improve populations' perceived health