Dynamics of a single exciton in strongly correlated bilayers

We formulated an effective theory for a single interlayer exciton in a bilayer quantum antiferromagnet, in the limit that the holon and doublon are strongly bound onto one interlayer rung by the Coulomb force. Upon using a rung linear spin wave approximation of the bilayer Heisenberg model, we calculated the spectral function of the exciton for a wide range of the interlayer Heisenberg coupling \alpha=J_{\perp}/Jz. In the disordered phase at large \alpha, a coherent quasiparticle peak appears representing free motion of the exciton in a spin singlet background. In the N\'{e}el phase, which applies to more realistic model parameters, a ladder spectrum arises due to Ising confinement of the exciton. The exciton spectrum is visible in measurements of the dielectric function, such as c-axis optical conductivity measurements.Comment: 28 pages, 12 figure

An experimental proposal to study collapse of the wave function in travelling-wave parametric amplifiers

The read-out of a microwave qubit state occurs using an amplification chain that enlarges the quantum state to a signal detectable with a classical measurement apparatus. However, at what point in this process did we really `measure' the quantum state? In order to investigate whether the `measurement' takes place in the amplification chain, we propose to construct a microwave interferometer that has a parametric amplifier added to each of its arms. Feeding the interferometer with single photons, the visibility depends on the gain of the amplifiers and whether a measurement collapse has taken place during the amplification process. We calculate the interference visibility as given by standard quantum mechanics as a function of gain, insertion loss and temperature and find a magnitude of $1/3$ in the limit of large gain without taking into account losses. This number reduces to $0.26$ in case the insertion loss of the amplifiers is $2.2$ dB at a temperature of $50$ mK. We show that if the wave function collapses within the interferometer, we will measure a reduced visibility compared to the prediction from standard quantum mechanics once this collapse process sets in.Comment: 21 pages and 23 figures (including appendices and subfigures). v4: Abstract and introduction rewritten and note on stochasticity of quantum state collapse added to section 6. v5: no content changes w.r.t. v

Space--time fluctuations and the spreading of wavepackets

Using a density matrix description in space we study the evolution of wavepackets in a fluctuating space-time background. We assume that space-time fluctuations manifest as classical fluctuations of the metric. From the non-relativistic limit of a non-minimally coupled Klein-Gordon equation we derive a Schr\"odinger equation with an additive gaussian random potential. This is transformed into an effective master equation for the density matrix. The solutions of this master equation allow to study the dynamics of wavepackets in a fluctuating space-time, depending on the fluctuation scenario. We show how different scenarios alter the diffusion properties of wavepackets.Comment: 11 page

Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes

Conjugates of a dicarba analogue of octreotide, a potent somatostatin agonist whose receptors are overexpressed on tumor cells, with [PtCl 2(dap)] (dap = 1-(carboxylic acid)-1,2-diaminoethane) (3), [(η 6-bip)Os(4-CO 2-pico)Cl] (bip = biphenyl, pico = picolinate) (4), [(η 6-p-cym)RuCl(dap)] + (p-cym = p-cymene) (5), and [(η 6-p-cym)RuCl(imidazole-CO 2H)(PPh 3)] + (6), were synthesized by using a solid-phase approach. Conjugates 3-5 readily underwent hydrolysis and DNA binding, whereas conjugate 6 was inert to ligand substitution. NMR spectroscopy and molecular dynamics calculations showed that conjugate formation does not perturb the overall peptide structure. Only 6 exhibited antiproliferative activity in human tumor cells (IC 50 = 63 ± 2 μ in MCF-7 cells and IC 50 = 26 ± 3 μ in DU-145 cells) with active participation of somatostatin receptors in cellular uptake. Similar cytotoxic activity was found in a normal cell line (IC 50 = 45 ± 2.6 μ in CHO cells), which can be attributed to a similar level of expression of somatostatin subtype-2 receptor. These studies provide new insights into the effect of receptor-binding peptide conjugation on the activity of metal-based anticancer drugs, and demonstrate the potential of such hybrid compounds to target tumor cells specifically. © 2012 American Chemical Society

Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs

This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging. Current research addressing the problems associated with platinum drugs has focused on other metal-based therapeutics that have different modes of action and on prodrug and targeting strategies in an effort to diminish the side-effects of cisplatin chemotherapy

Doctoral Dissertation Improvement Grant: Early Human Settlement of the High-Altitude Pucuncho Basin, Southern Peruvian Andes

Under the direction of Dr. Daniel Sandweiss, Mr. Kurt Rademaker will collect data for his doctoral dissertation research. His project focuses on determining the timing of early human occupation in the Andes Mountains. Human settlement of Earth\u27s high-altitude mountains and plateaus is among the most recent of our species\u27 bio-geographic expansions. Current anthropological models emphasize the physiographic and biological challenges inherent to these extreme environments to explain a lack of pre-11,000 year-old archaeological evidence above 3500 m elevation in the Andes and on the high Tibetan Plateau. However few archaeological studies targeting hunter-gatherer sites have been conducted in these areas.This interdisciplinary project\u27s primary objectives are to better understand the timing, environmental setting, and adaptations involved in human settlement of the high Andes of southern Peru. Rademaker\u27s investigations so far have led to the discovery of early archaeological sites in the Pucuncho Basin, a wetland oasis ringed by glaciated volcanoes and situated at ~4500 m (~14,760 ft) elevation. One of these sites, Cuncaicha rockshelter, has yielded preliminary radiocarbon dates that indicate an initial settlement of this high-altitude area between 12,400 and 11,800 years ago. These dates establish Cuncaicha as one of the oldest known directly-dated archaeological sites in the Andes Mountains and the highest ice-age site yet discovered anywhere in the world.The final laboratory phase of this dissertation project, to be funded by NSF, will significantly strengthen the preliminary chronological data from Cuncaicha shelter and provide information on the development of local habitats important to Andean animals and people for successful colonization of high-altitude zones. Rademaker will obtain additional radiocarbon dates for the Cuncaicha rockshelter site and the nearby Rio Blanco geologic section. These archaeological and paleoecologic data will be directly comparable with local glacial geologic records, and these comparisons will shed light on links between late ice-age climatic change, the formation of Andean habitats, and early human settlement of extreme high-altitude environments. This project will have several broad impacts. By conducting pretreatment of samples at the University of Arizona accelerator mass spectrometry lab, Rademaker will receive valuable training in archaeological scientific methodology. Completion of this dissertation project will yield numerous peer-reviewed journal publications and ultimately lead to publication of an edited volume for a more general audience. The project team has given, and will continue to give, guest lectures at Peruvian and North American universities, in addition to presenting scientific results at professional meetings at home and abroad. Since 2005 this project has provided limited temporary economic benefits to some local inhabitants of the Pucuncho Basin who have assisted in surveys and excavation and provided related support for the project team. The team has brought medicine, vitamins, and educational materials for the school children in Pucuncho\u27s three villages and worked to instill a conservation ethic about archaeological remains in the region. Continued scientific work in the Pucuncho area, which will build upon this Ph.D. dissertation project, will undoubtedly reinforce this ethic and yield additional valuable information on climatic change, ecology, and human prehistory

Aquatic community response to volcanic eruptions on the Ecuadorian Andean flank: evidence from the palaeoecological record

Aquatic ecosystems in the tropical Andes are under increasing pressure from human modification of the landscape (deforestation and dams) and climatic change (increase of extreme events and 1.5 °C on average temperatures are projected for AD 2100). However, the resilience of these ecosystems to perturbations is poorly understood. Here we use a multi-proxy palaeoecological approach to assess the response of aquatic ecosystems to a major mechanism for natural disturbance, volcanic ash deposition. Specifically, we present data from two Neotropical lakes located on the eastern Andean flank of Ecuador. Laguna Pindo (1°27.132′S–78°04.847′W) is a tectonically formed closed basin surrounded by a dense mid-elevation forest, whereas Laguna Baños (0°19.328′S–78°09.175′W) is a glacially formed lake with an inflow and outflow in high Andean Páramo grasslands. In each lake we examined the dynamics of chironomids and other aquatic and semi-aquatic organisms to explore the effect of thick (> 5 cm) volcanic deposits on the aquatic communities in these two systems with different catchment features. In both lakes past volcanic ash deposition was evident from four large tephras dated to c.850 cal year BP (Pindo), and 4600, 3600 and 1500 cal year BP (Baños). Examination of the chironomid and aquatic assemblages before and after the ash depositions revealed no shift in composition at Pindo, but a major change at Baños occurred after the last event around 1500 cal year BP. Chironomids at Baños changed from an assemblage dominated by Pseudochironomus and Polypedilum nubifer-type to Cricotopus/Paratrichocladius type-II, and such a dominance lasted for approximately 380 years. We suggest that, despite potential changes in the water chemistry, the major effect on the chironomid community resulted from the thickness of the tephra being deposited, which acted to shallow the water body beyond a depth threshold. Changes in the aquatic flora and fauna at the base of the trophic chain can promote cascade effects that may deteriorate the ecosystem, especially when already influenced by human activities, such as deforestation and dams, which is frequent in the high Andes

Evaluation of Dynamic Models of Distillation Columns with Emphasis on the Initial Response

The flow dynamics (tray hydraulics) are of key importance for the initial dynamic response of distillation columns. The most important parameters are the liquid holdup, the liquid hydraulic time constant and the vapor constant representing the initial effect of a change in vapor flow on liquid flow. In the paper we present methods for determining these parameters experimentally, and compare the results with estimates from available correlations such as the Francis Weir formula

Visualization of HIV-1 interactions with penile and foreskin epithelia: clues for female-to-male HIV transmission

To gain insight into female-to-male HIV sexual transmission and how male circumcision protects against this mode of transmission, we visualized HIV-1 interactions with foreskin and penile tissues in ex vivo tissue culture and in vivo rhesus macaque models utilizing epifluorescent microscopy. 12 foreskin and 14 cadaveric penile specimens were cultured with R5-tropic photoactivatable (PA)-GFP HIV-1 for 4 or 24 hours. Tissue cryosections were immunofluorescently imaged for epithelial and immune cell markers. Images were analyzed for total virions, proportion of penetrators, depth of virion penetration, as well as immune cell counts and depths in the tissue. We visualized individual PA virions breaching penile epithelial surfaces in the explant and macaque model. Using kernel density estimated probabilities of localizing a virion or immune cell at certain tissue depths revealed that interactions between virions and cells were more likely to occur in the inner foreskin or glans penis (from local or cadaveric donors, respectively). Using statistical models to account for repeated measures and zero-inflated datasets, we found no difference in total virions visualized at 4 hours between inner and outer foreskins from local donors. At 24 hours, there were more virions in inner as compared to outer foreskin (0.0495 +/- 0.0154 and 0.0171 +/- 0.0038 virions/image, p = 0.001). In the cadaveric specimens, we observed more virions in inner foreskin (0.0507 +/- 0.0079 virions/image) than glans tissue (0.0167 +/- 0.0033 virions/image, p<0.001), but a greater proportion was seen penetrating uncircumcised glans tissue (0.0458 +/- 0.0188 vs. 0.0151 +/- 0.0100 virions/image, p = 0.099) and to significantly greater mean depths (29.162 +/- 3.908 vs. 12.466 +/- 2.985 μm). Our in vivo macaque model confirmed that virions can breach penile squamous epithelia in a living model. In summary, these results suggest that the inner foreskin and glans epithelia may be important sites for HIV transmission in uncircumcised men