44 research outputs found

    Environmental Attitude and Environmental Behavior of Catholic Colleges’ Employees in Ilocos Sur, Philippines

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    International audienceThe study was intended to measure the understanding and attitudes of employees of Catholic Colleges in Ilocos Sur Province toward the environment and how such attitudes affect their behavior toward the environment. It was found that overall the employees were not certain related to their attitudes toward the environment and such ambivalent attitudes affect their behavior toward the environment. The study concludes that such ambivalent attitudes are caused by lack of understanding about environmental ethics. It is recommended therefore to improve awareness or understanding about natural environment through seminars on environment and to include environmental ethics in the curriculum

    Moral Leadership of Middle-Lower Level Managers and Employee's Job Satisfaction of Divine Word Colleges in Region I, Philippines as Perceived by the Employees

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    The study wants to determine the effect of moral leadership and job satisfactionInternational audienceThe study was intended to measure the moral leadership of middle-lower level managers of Divine Word Colleges in Region I, Philippines and how it affects the job satisfaction of employees. In order to strengthen the study, theories on moral leadership were presented and related literature and studies were reviewed. The conceptual framework of the study was established on the four variables such as integrity, trust, ethical leadership, and honesty as independent variables and job satisfaction as dependent variable. The framework indicates the relationship of both variables: moral leadership and job satisfaction. Based on the conceptual framework, the statements of the problems were proposed and questionnaires were made. The questionnaires were adopted from the study of Foronda (2010). The study used the descriptive correlational research design and used Pearson r to determine the relationship between moral leadership and job satisfaction. The study found that moral leadership of middle-lower level managers of Divine Word Colleges in Region I, Philippines in terms of integrity, trust, ethical relationship and honesty is very good and that moral leadership correlates to job satisfaction of employees

    Genetic and clinical characteristics of Filipino patients with Gaucher disease

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    Gaucher disease (GD) is a lysosomal storage disorder caused by the deficiency of the β-glucocerebrosidase enzyme due to disease causing mutations in the GBA1 (glucosidase beta acid) gene, leading to the abnormal accumulation of the lipid glucocerebroside in lysosomal macrophages. This is a review of the clinical features and molecular profiles of 14 Filipino patients with GD. Five patients presented with type 1 disease, two had type 2 GD and seven had type 3 GD. The age of onset for all types was between 1 and 2 years of age but there was a delay of 2.2 years from the time of symptom onset to confirmation of diagnosis. Hepatosplenomegaly, anemia and thrombocytopenia were present in most of the patients. Stunting was seen in 64.3% and bone abnormalities were present in 63.6%. The most common mutant allele detected in this cohort was L483P (previously L444P), followed by F252I, P358A and G241R. IVS2+1 G>A, N409S and G416S mutations were reported singularly. There were 3 patients who were found to have N131S mutations and one patient with D257V mutation, mutant alleles that have only been reported among the Filipinos to date. Except for N409S, the mutations found in this cohort were generally severe and were congruent with the severe phenotypes found in most patients. Of the 14 patients, only 6 were able to undergo enzyme replacement therapy which significantly improved the hematologic parameters and decreased the sizes of the liver and spleen but did not consistently improve the growth and skeletal abnormalities nor alleviate the neurological manifestations of our patients with GD. Improved monitoring through recommended modalities for assessments and tools for evaluation should be implemented in order to fully appreciate the severity of the disease and accuracy of the response to treatment. Keywords: Gaucher disease, Filipinos, β glucocerebrosidase, GBA1 mutations, Enzyme replacement therapy, Severe phenotyp

    Volcanoes magnify Metro Manila's southwest monsoon rains and lethal floods

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    Many volcanoes worldwide are located near populated cities that experience monsoon seasons, characterised by shifting winds each year. Because of the severity of flood impact to large populations, it is worthy of investigation in the Philippines and elsewhere to better understand the phenomenon for possible hazard mitigating solutions, if any. During the monsoon season, the change in flow direction of winds brings moist warm air to cross the mountains and volcanoes in western Philippines and cause lift into the atmosphere, which normally leads to heavy rains and floods. Heavy southwest monsoon rains from 18-21 August 2013 flooded Metro Manila (population of 12 million) and its suburbs paralyzing the nation’s capital for an entire week. Called the 2013 Habagat event, it was a repeat of the 2012 Habagat or extreme southwest monsoon weather from 6-9 August, which delivered record rains in the mega city. In both the 2012 and 2013 Habagat events, cyclones, the usual suspects for the delivery of heavy rains, were passing northeast of the Philippine archipelago, respectively, and enhanced the southwest monsoon. Analysis of Doppler data, rainfall measurements, and Weather Research and Forecasting (WRF) model simulations show that two large stratovolcanoes, Natib and Mariveles, across from Manila Bay and approximately 70 km west of Metro Manila, played a substantial role in delivering extreme rains and consequent floods to Metro Manila. The study highlights how volcanoes, with their shape and height create an orographic effect and dispersive tail of rain clouds which constitutes a significant flood hazard to large communities like Metro Manila

    Chloroquine inhibits glioblastoma cell proliferation.

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    <p>U87MG and Gli36ΔEGFR cells were incubated with increasing concentrations of CQ for 7–10 days. At the end of the growth period colonies were fixed, stained and counted. After taking into account the plating efficiency for each cell line, the surviving fraction is the ratio of the number of colonies counted and the initial number of cells plated. Mean ± S.D., n = 3.</p
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