PPAR Alpha Regulation of the Immune Response and Autoimmune Encephalomyelitis

PPARs are members of the steroid hormone nuclear receptor superfamily and play an important role in the regulation of lipid metabolism, energy balance, artherosclerosis and glucose control. Recent studies suggest that they play an important role in regulating inflammation. This review will focus on PPAR-α regulation of the immune response. We describe how PPAR-α regulates differentiation of T cells by transactivation and/or interaction with other transcription factors. Moreover, PPAR-α agonists have been shown to ameliorate experimental autoimmune encephalomyelitis (EAE) in mice, suggesting that they could provide a therapy for human autoimmune diseases such as multiple sclerosis

Heat conduction in elastic systems : fourier versus cattaneo

Papers presented to the 11th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, South Africa, 20-23 July 2015.Please read abstract in article.am201

Energy decay for Timoshenko systems of memory type

AbstractLinear systems of Timoshenko type equations for beams including a memory term are studied. The exponential decay is proved for exponential kernels, while polynomial kernels are shown to lead to a polynomial decay. The optimality of the results is also investigated

On the Nature of Singularities in Plane Symmetric Scalar Field Cosmologies

The nature of the initial singularity in spatially compact plane symmetric scalar field cosmologies is investigated. It is shown that this singularity is crushing and velocity dominated and that the Kretschmann scalar diverges uniformly as it is approached. The last fact means in particular that a maximal globally hyperbolic spacetime in this class cannot be extended towards the past through a Cauchy horizon. A subclass of these spacetimes is identified for which the singularity is isotropic.Comment: 7 pages, MPA-AR-94-

A class of plane symmetric perfect-fluid cosmologies with a Kasner-like singularity

We prove the existence of a class of plane symmetric perfect-fluid cosmologies with a (-1/3, 2/3, 2/3) Kasner-like singularity. These solutions of the Einstein equations depend on two smooth functions of one space coordinate. They are constructed by solving a symmetric hyperbolic system of Fuchsian equations.Comment: LaTeX, 15 pages, no figures, to appear in CQG, correction to existence proo

Global well-posedness of the Kirchhoff equation and Kirchhoff systems

This article is devoted to review the known results on global well-posedness for the Cauchy problem to the Kirchhoff equation and Kirchhoff systems with small data. Similar results will be obtained for the initial-boundary value problems in exterior domains with compact boundary. Also, the known results on large data problems will be reviewed together with open problems.Comment: arXiv admin note: text overlap with arXiv:1211.300

A phase 2 multicenter study of ublituximab, a novel glycoengineered anti-CD20 monoclonal antibody, in patients with relapsing forms of multiple sclerosis.

Background: Ublituximab, a novel monoclonal antibody (mAb) targeting a unique epitope on the CD20 antigen, is glycoengineered for enhanced B-cell targeting through antibody-dependent cellular cytotoxicity (ADCC). Greater ADCC may allow lower doses and shorter infusion times versus other anti-CD20 mAbs. Objective: The objective was to determine optimal dose, infusion time, and activity of ublituximab in relapsing multiple sclerosis. Methods: This is a phase 2, placebo-controlled study. Patients received three ublituximab infusions (150 mg over 1-4 hours on day 1 and 450-600 mg over 1-3 hours on day 15 and week 24) in six dosing cohorts. The primary endpoint was B-cell depletion. Results: In all cohorts (N = 48), median B-cell depletion was >99% by week 4, maintained at weeks 24 and 48. Most common adverse events (AEs) were infusion-related reactions (all grade 1-2), with no apparent increased incidence at shorter infusion times. There were no AE-related discontinuations. At weeks 24 and 48, no T1 gadolinium-enhancing lesions (p = 0.003) and a 10.6% decrease in T2 lesion volume (p = 0.002) were detected. The annualized relapse rate was 0.07; 93% remained relapse free on study. Overall, 74% of patients had no evidence of disease activity (NEDA). Conclusion: Ublituximab was safely infused as rapid as 1 hour, producing robust B-cell depletion and profound reductions in magnetic resonance imaging (MRI) activity and relapses