1,130 research outputs found
Pyridine is an organocatalyst for the reductive ozonolysis of alkenes
Whereas the cleavage of alkenes by ozone typically generates peroxide intermediates that must be decomposed in an accompanying step, ozonolysis in the presence of pyridine directly generates ketones or aldehydes through a process that neither consumes pyridine nor generates any detectable peroxides. The reaction is hypothesized to involve nucleophile-promoted fragmentation of carbonyl oxides via formation of zwitterionic peroxyacetals
Pamidronate Administration During Pregnancy and Lactation Induces Temporal Preservation of Maternal Bone Mass in a Mouse Model of Osteogenesis Imperfecta
During pregnancy and lactation, the maternal skeleton undergoes significant bone loss through increased resorption to provide the necessary calcium supply to the developing fetus and suckling neonate. This period of skeletal vulnerability has not been clearly associated with increased maternal fracture risk, but these physiological conditions can exacerbate an underlying metabolic bone condition like osteogenesis imperfecta. Although bisphosphonates (BPs) are commonly used in postmenopausal women, there are cases where premenopausal women taking BPs become pregnant. Given BPsâ long halfâlife, there is a need to establish how BPs affect the maternal skeleton during periods of demanding metabolic bone changes that are critical for the skeletal development of their offspring. In the present study, pamidronateâ (PAMâ) amplified pregnancyâinduced bone mass gains and lactationâinduced bone loss were prevented. This preservation of bone mass was less robust when PAM was administered at late stages of lactation compared with early pregnancy and first day of lactation. Pregnancyâinduced osteocyte osteolysis was also observed and was unaffected with PAM treatment. No negative skeletal effects were observed in offspring from PAMâtreated dams despite lactationâinduced bone loss prevention. These findings provide important insight into (1) a treatment window for when PAM is most effective in preserving maternal bone mass, and (2) the maternal changes in bone metabolism that maintain calcium homeostasis crucial for fetal and neonatal bone development. © 2019 American Society for Bone and Mineral ResearchPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153136/1/jbmr3831.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153136/2/jbmr3831_am.pd
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Efficacy of Elaborated Semantic Features Analysis in Aphasia: a quasi-randomised controlled trial
Background: Word finding difficulty is one of the most common features of aphasia. Semantic Features Analysis (SFA) directly aims to improve word finding in people with aphasia. Evidence from systematic reviews suggests that SFA leads to positive outcomes, yet the evidence comprises single case studies and case series. There is a need to evaluate the efficacy of SFA in controlled group studies/trials.
Aims: To evaluate the efficacy of Elaborated Semantic Feature Analysis (ESFA) for word finding in people with aphasia. We investigated: (a) the efficacy of ESFA versus a delayed therapy/control, (b) the efficacy of two therapy approachesâ individual versus a combination of individual and group therapy.
Methods and procedures: We ran a multi-centre, quasi-randomised controlled trial, nested in a larger study (Thales-Aphasia). Participants were recruited from community settings. They had to be people with aphasia due to stroke at least four months post-onset. Participants were randomized to individual vs combination vs delayed therapy/control groups. Both therapy groups had three hours of ESFA per week for 12 weeks. Delayed therapy/control group had no intervention for 12 weeks and were then randomized to either individual or combination therapy. The primary outcome was confrontation naming. Secondary outcomes were the Boston Naming Test, Discourse, the Functional Assessment of Communication Skills for adults (ASHAâFACS), the Stroke and Aphasia Quality of Life scale (SAQOL-39g), the General Health Questionnaire-12 item, and the EQ-5D.
Outcomes and Results: Of the 72 participants of the Thales-Aphasia project, 58 met eligibility criteria for speech-language therapy and 39 were allocated to ESFA. The critical p-value was adjusted for multiple comparisons (.005). For the therapy versus control comparison, there was a significant main effect of time on the primary outcome (p<.001, η2p=.42) and a significant interaction effect (p=.003, η2p=.21). An interaction effect for the SAQOL-39g (p=.015, η2p=.11) and its psychosocial domain (p=.013, η2p=.12) did not remain significant after Bonferroni adjustment. For the individual versus combination ESFA comparison, there were significant main effects of time on the primary outcome (p<.001, η2p=.49), the BNT (p<.001, η2p=.29) and the ASHA-FACS (p=.001, η2p=.18). Interaction and group effects were not significant.
Conclusion: Though underpowered, this study provides evidence on the efficacy of ESFA to improve word finding in aphasia, with gains similar in the two therapy approaches.
Trial registration: ISRCTN71455409, https://doi.org/10.1186/ISRCTN7145540
Understanding the psychosocial impact of weight loss following bariatric surgery: a qualitative study
Abstract
Background
Bariatric surgery leads to changes in mental health, quality of life and social functioning, yet these outcomes differ among individuals. In this study, we explore patientsâ psychosocial experiences following bariatric surgery and elucidate the individual-level factors that may drive variation in psychosocial outcomes.
Methods
Eleven semi-structured focus groups with Michigan Bariatric Surgery Collaborative (MBSC) patients (nâ=â77). Interviews were audio recorded, transcribed verbatim, and analyzed using a grounded theory approach. Data on participant demographic characteristics were abstracted from the MBSC clinical registry.
Results
Most focus group participants were female (89%), white (64%), and married (65%). We identified three major themes: (1) change in self-perception; (2) change in perception by others; and (3) change in relationships. Each theme includes 3 sub-themes, demonstrating a range of positive and negative psychosocial experiences. For example, weight loss led to increased self-confidence among many participants while others described a loss of self-identity. Some noted improved relationships with family or friends while others experienced worsening or even loss of relationships due to perceived jealousy.
Conclusion
Weight loss following bariatric surgery leads to complex changes in self-perception and inter-personal relationships, which may be proximal mediators of commonly assessed mental health outcomes such as depression. Individuals considering bariatric surgery may benefit from anticipatory guidance about these diverse experiences, and post-surgical longitudinal monitoring should include evaluation for adverse psychosocial events.https://deepblue.lib.umich.edu/bitstream/2027.42/146725/1/40608_2018_Article_215.pd
The Weak Clustering of Gas-Rich Galaxies
We examine the clustering properties of HI-selected galaxies through an
analysis of the HI Parkes All-Sky Survey Catalogue (HICAT) two-point
correlation function. Various sub-samples are extracted from this catalogue to
study the overall clustering of HI-rich galaxies and its dependence on
luminosity, HI gas mass and rotational velocity. These samples cover the entire
southern sky Dec < 0 deg, containing up to 4,174 galaxies over the radial
velocity range 300-12,700 km/s. A scale length of r_0 = 3.45 +/- 0.25 Mpc/h and
slope of gamma = 1.47 +/- 0.08 is obtained for the HI-rich galaxy real-space
correlation function, making gas-rich galaxies among the most weakly clustered
objects known. HI-selected galaxies also exhibit weaker clustering than
optically selected galaxies of comparable luminosities. Good agreement is found
between our results and those of synthetic HI-rich galaxy catalogues generated
from the Millennium Run CDM simulation. Bisecting HICAT using different
parameter cuts, clustering is found to depend most strongly on rotational
velocity and luminosity, while the dependency on HI mass is marginal. Splitting
the sample around v_rot = 108 km/s, a scale length of r_0 = 2.86 +/- 0.46 Mpc/h
is found for galaxies with low rotational velocities compared to r_0 = 3.96 +/-
0.33 Mpc/h for the high rotational velocity sample.Comment: Accepted for publication in the Astrophysical Journa
Alexithymia in individuals with chronic pain and its relation to pain intensity, physical interference, depression, and anxiety:a systematic review and meta-analysis
Numerous studies have examined how alexithymia (difficulty identifying and describing one's emotions and a preference for externally oriented thinking) relates to chronic pain and associated disability. We conducted a systematic review and meta-analysis to summarize individual studies that either assessed alexithymia in individuals with chronic pain vs controls or related alexithymia to pain intensity, physical interference, depression, and anxiety. We searched MEDLINE, Embase, and PsycINFO from inception through June 2017; 77 studies met the criteria (valid assessment of alexithymia in adults or children with any chronic pain condition) and were included in analyses (n = 8019 individuals with chronic pain). Primary analyses indicated that chronic pain samples had significantly higher mean alexithymia scores compared with nonclinical (d = 0.81) and clinical nonpain (d = 0.55) controls. In chronic pain samples, alexithymia was significantly positively associated with pain intensity (d = 0.20), physical interference (d = 0.17), depression (d = 0.46), and anxiety (d = 0.43). Secondary meta-analyses of 14 studies that conducted partial correlations that controlled for negative affect-related measures revealed that alexithymia was no longer significantly related to pain intensity or interference. Meta-analysis findings demonstrated that alexithymia is elevated in individuals with chronic pain and related to greater pain intensity and physical interference, although the latter relationships may be accounted for by negative affect. Critical future work is needed that examines alexithymia assessed using non-self-report measures, develops a person-centered perspective on this construct, and identifies how alexithymia is relevant to the assessment and treatment of individuals with chronic pain.</p
Reducing Poverty in CaliforniaâŠPermanently
If California were to seriously commit to equalizing opportunity and reducing poverty, how might that commitment best be realized?
This is of course a hypothetical question, as there is no evidence that California is poised to make such a serious commitment, nor have many other states gone much beyond the usual lip-service proclamations. There are many reasons for Californiaâs complacency, but an important one is that most people think that poverty is intractable and that viable solutions to it simply donât exist.
When Californians know what needs to be done, they tend to go forward and get it done. When, for example, the stateâs roads are in disrepair, there are rarely paralyzing debates about exactly how to go about fixing them; instead we proceed with the needed repairs as soon as the funds to do so are appropriated. The same type of sure and certain prescription might appear to be unavailable when it comes to reducing poverty. It is hard not to be overwhelmed by the cacophony of voices yielding a thick stream of narrow-gauge interventions, new evaluations, and piecemeal proposals.1
Although the research literature on poverty is indeed large and may seem confusing, recent advances have in fact been so fundamental that it is now possible to develop a science-based response to poverty. In the past, the causes of poverty were not well understood, and major interventions, such as the War on Poverty, had to be built more on hunch than science. It is an altogether different matter now. The causes of poverty are well established, and the effects of many possible policy responses to poverty are likewise well established. The simple purpose of this essay is to assemble these advances into a coherent plan that would, if implemented, reduce poverty in California substantially
On Star Formation and the Non-Existence of Dark Galaxies
We investigate whether a baryonic dark galaxy or `galaxy without stars' could
persist indefinitely in the local universe, while remaining stable against star
formation. To this end, a simple model has been constructed to determine the
equilibrium distribution and composition of a gaseous protogalactic disk.
Specifically, we determine the amount of gas that will transit to a Toomre
unstable cold phase via the H2 cooling channel in the presence of a UV--X-ray
cosmic background radiation field.
All but one of the models are predicted to become unstable to star formation.
Moreover, we find that all our model objects would be detectable via HI line
emission, even in the case that star formation is potentially avoided. These
results are consistent with the non-detection of isolated extragalactic HI
clouds with no optical counterpart (galaxies without stars) by HIPASS.
Additionally, where star formation is predicted to occur, we determine the
minimum interstellar radiation field required to restore gravothermal
stability, which we then relate to a minimum global star formation rate. This
leads to the prediction of a previously undocumented relation between HI mass
and star formation rate that is observed for a wide variety of dwarf galaxies
in the HI mass range 10^8--10^10 M_sun. The existence of such a relation
strongly supports the notion that the well observed population of dwarf
galaxies represent the minimum rates of self-regulating star formation in the
universe. (Barely abridged)Comment: 19 pages, 8 figures, TeX using emulateapj.cls, v2 accepted for
publication in ApJ (16/8/5) with one figure deleted and a number of minor
clarifying revision
Nonlocal Conductivity in the Vortex-Liquid Regime of a Two-Dimensional Superconductor
We have simulated the time-dependent Ginzburg-Landau equation with thermal
fluctuations, to study the nonlocal dc conductivity of a superconducting film.
Having examined points in the phase diagram at a wide range of temperatures and
fields below the mean-field upper critical field, we find a portion of the
vortex-liquid regime in which the nonlocal ohmic conductivity in real space is
negative over a distance several times the spacing between vortices. The effect
is suppressed when driven beyond linear response. Earlier work had predicted
the existence of such a regime, due to the high viscosity of a
strongly-correlated vortex liquid. This behavior is clearly distinguishable
from the monotonic spatial fall-off of the conductivity in the higher
temperature or field regimes approaching the normal state. The possibilities
for experimental study of the nonlocal transport properties are discussed.Comment: 18 pages, revtex, 6 postscript figure
2021 assessment of the status of the West Coast Demersal Scalefish Resource
A recovery program for the West Coast Demersal Scalefish Resource was introduced between late 2007 and early 2010, based on the maintenance of retained catches of demersal species (overall suite and each indicator species) by both the commercial and recreational sectors below 50% of the catches reported in 2005/06 (original catch recovery benchmarks)
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