Comparability of lexical corpora: Word frequency in phonological generalization

Statistical regularities in language have been examined for new insight to the language acquisition process. This line of study has aided theory advancement, but it also has raised methodological concerns about the applicability of corpora data to child populations. One issue is whether it is appropriate to extend the regularities observed in the speech of adults to developing linguistic systems. The purpose of this paper is to establish the comparability of lexical corpora in accounting for behavioural effects of word frequency on children's phonological generalization. Four word frequency corpora were evaluated in comparison of child/adult and written/spoken sources. These were applied post-hoc to generalization data previously reported for two preschool children. Results showed that the interpretation of phonological generalization was the same within and across children, regardless of the corpus being used. Phonological gains were more evident in low than high frequency words. The findings have implications for the design of probabilistic studies of language acquisition and clinical treatment programmes.National Institutes of Health DC00433, RR7031K, DC00076, DC001694 (PI: Gierut)This is an Accepted Manuscript of an article published by Taylor & Francis in Clinical Linguistics & Phonetics on June 2007, available online: http://wwww.tandfonline.com/10.1080/02699200701299891

Comparability of lexical corpora : Word frequency in phonological generalization.

Abstract Statistical regularities in language have been examined for new insight to the language acquisition process. This line of study has aided theory advancement, but it also has raised methodological concerns about the applicability of corpora data to child populations. One issue is whether it is appropriate to extend the regularities observed in the speech of adults to developing linguistic systems. The purpose of this paper is to establish the comparability of lexical corpora in accounting for behavioural effects of word frequency on children's phonological generalization. Four word frequency corpora were evaluated in comparison of child/adult and written/spoken sources. These were applied post-hoc to generalization data previously reported for two preschool children. Results showed that the interpretation of phonological generalization was the same within and across children, regardless of the corpus being used. Phonological gains were more evident in low than high frequency words. The findings have implications for the design of probabilistic studies of language acquisition and clinical treatment programmes

A controlled study of cold dust content in galaxies from z=0−2z=0-2

At $z=1-3$, the formation of new stars is dominated by dusty galaxies whose far-IR emission indicates they contain colder dust than local galaxies of a similar luminosity. We explore the reasons for the evolving IR emission of similar galaxies over cosmic time using: 1) Local galaxies from GOALS $(L_{\rm IR}=10^{11}-10^{12}\,L_\odot)$; 2) Galaxies at $z\sim0.1-0.5$ from the 5MUSES ($L_{\rm IR}=10^{10}-10^{12}\,L_\odot$); 3) IR luminous galaxies spanning $z=0.5-3$ from GOODS and Spitzer xFLS ($L_{\rm IR}>10^{11}\,L_\odot$). All samples have Spitzer mid-IR spectra, and Herschel and ground-based submillimeter imaging covering the full IR spectral energy distribution, allowing us to robustly measure $L_{\rm IR}^{\rm\scriptscriptstyle SF}$, $T_{\rm dust}$, and $M_{\rm dust}$ for every galaxy. Despite similar infrared luminosities, $z>0.5$ dusty star forming galaxies have a factor of 5 higher dust masses and 5K colder temperatures. The increase in dust mass is linked with an increase in the gas fractions with redshift, and we do not observe a similar increase in stellar mass or star formation efficiency. $L_{160}^{\rm\scriptscriptstyle SF}/L_{70}^{\rm\scriptscriptstyle SF}$, a proxy for $T_{\rm dust}$, is strongly correlated with $L_{\rm IR}^{\rm\scriptscriptstyle SF}/M_{\rm dust}$ independently of redshift. We measure merger classification and galaxy size for a subsample, and there is no obvious correlation between these parameters and $L_{\rm IR}^{\rm \scriptscriptstyle SF}/M_{\rm dust}$ or $L_{160}^{\rm\scriptscriptstyle SF}/L_{70}^{\rm\scriptscriptstyle SF}$. In dusty star forming galaxies, the change in $L_{\rm IR}^{\rm\scriptscriptstyle SF}/M_{\rm dust}$ can fully account for the observed colder dust temperatures, suggesting that any change in the spatial extent of the interstellar medium is a second order effect.Comment: Accepted for publication in ApJ. 21 pages, 11 figure

The State of Preschool 2009

Provides data on state-funded pre-K programs for the 2008-09 school year and examines the recession's effects on expanding enrollment and raising standards. Ranks states by percentage of children enrolled, funding per child, and quality benchmarks met

Linking galaxy structural properties and star formation activity to black hole activity with IllustrisTNG

We study the connection between active galactic nuclei (AGN) and their host galaxies through cosmic time in the large-scale cosmological IllustrisTNG simulations. We first compare BH properties, i.e. the hard X-ray BH luminosity function, AGN galaxy occupation fraction, and distribution of Eddington ratios, to available observational constraints. The simulations produce a population of BHs in good agreement with observations, but we note an excess of faint AGN in hard X-ray (L_x ~ 10^{43-44} erg/s), and a lower number of bright AGN (L_x>10^{44} erg/s), a conclusion that varies quantitatively but not qualitatively with BH luminosity estimation method. The lower Eddington ratios of the 10^{9} Msun BHs compared to observations suggest that AGN feedback may be too efficient in this regime. We study galaxy star formation activity and structural properties, and design sample-dependent criteria to identify different galaxy types (star-forming/quiescent, extended/compact) that we apply both to the simulations and observations from the candels fields. We analyze how the simulated and observed galaxies populate the specific star formation rate - stellar mass surface density diagram. A large fraction of the z=0 M_{star}>10^{11} Msun quiescent galaxies first experienced a compaction phase (i.e. reduction of galaxy size) while still forming stars, and then a quenching event. We measure the dependence of AGN fraction on galaxies' locations in this diagram. After correcting the simulations with a redshift and AGN luminosity-dependent model for AGN obscuration, we find good qualitative and quantitative agreement with observations. The AGN fraction is the highest among compact star-forming galaxies (16-20% at z~1.5-2), and the lowest among compact quiescent galaxies (6-10% at z~1.5-2).Comment: 35 pages, 22 figures, accepted for publication in MNRA

The mass evolution of the first galaxies: stellar mass functions and star formation rates at 4<z<74 < z < 7 in the CANDELS GOODS-South field

We measure new estimates for the galaxy stellar mass function and star formation rates for samples of galaxies at $z \sim 4,~5,~6~\&~7$ using data in the CANDELS GOODS South field. The deep near-infrared observations allow us to construct the stellar mass function at $z \geq 6$ directly for the first time. We estimate stellar masses for our sample by fitting the observed spectral energy distributions with synthetic stellar populations, including nebular line and continuum emission. The observed UV luminosity functions for the samples are consistent with previous observations, however we find that the observed $M_{UV}$ - M$_{*}$ relation has a shallow slope more consistent with a constant mass to light ratio and a normalisation which evolves with redshift. Our stellar mass functions have steep low-mass slopes ($\alpha \approx -1.9$), steeper than previously observed at these redshifts and closer to that of the UV luminosity function. Integrating our new mass functions, we find the observed stellar mass density evolves from $\log_{10} \rho_{*} = 6.64^{+0.58}_{-0.89}$ at $z \sim 7$ to $7.36\pm0.06$ $\text{M}_{\odot} \text{Mpc}^{-3}$ at $z \sim 4$. Finally, combining the measured UV continuum slopes ($\beta$) with their rest-frame UV luminosities, we calculate dust corrected star-formation rates (SFR) for our sample. We find the specific star-formation rate for a fixed stellar mass increases with redshift whilst the global SFR density falls rapidly over this period. Our new SFR density estimates are higher than previously observed at this redshift.Comment: 28 pages, 23 figures, 2 appendices. Accepted for publication in MNRAS, August 7 201

Medical and Financial Risks Associated with Surgery in the Elderly Obese

OBJECTIVE: To study the medical and financial outcomes associated with surgery in elderly obese patients and to ask if obesity itself influences outcomes above and beyond the effects from comorbidities that are known to be associated with obesity. BACKGROUND: Obesity is a surgical risk factor not present in Medicare\u27s risk adjustment or payment algorithms, as BMI is not collected in administrative claims. METHODS: A total of 2045 severely or morbidly obese patients (BMI ≥ 35 kg/m, aged between 65 and 80 years) selected from 15,914 elderly patients in 47 hospitals undergoing hip and knee surgery, colectomy, and thoracotomy were matched to 2 sets of 2045 nonobese patients (BMI = 20-30 kg/m). A limited match controlled for age, sex, race, procedure, and hospital. A complete match also controlled for 30 additional factors such as diabetes and admission clinical data from chart abstraction. RESULTS: Mean BMI in the obese patients was 40 kg/m compared with 26 kg/m in the nonobese. In the complete match, obese patients displayed increased odds of wound infection: OR (odds ratio) = 1.64 (95% CI: 1.21, 2.21); renal dysfunction: OR = 2.05 (1.39, 3.05); urinary tract infection: OR = 1.55 (1.24, 1.94); hypotension: OR = 1.38 (1.07, 1.80); respiratory events: OR = 1.44 (1.19, 1.75); 30-day readmission: OR = 1.38 (1.08, 1.77); and a 12% longer length of stay (8%, 17%). Provider costs were 10% (7%, 12%) greater in obese than in nonobese patients, whereas Medicare payments increased only 3% (2%, 5%). Findings were similar in the limited match. CONCLUSIONS: Obesity increases the risks and costs of surgery. Better approaches are needed to reduce these risks. Furthermore, to avoid incentives to underserve this population, Medicare should consider incorporating incremental costs of caring for obese patients into payment policy and include obesity in severity adjustment models

Human Vascular Tissue Models Formed from Human Induced Pluripotent Stem Cell Derived Endothelial Cells

Here we describe a strategy to model blood vessel development using a well-defined induced pluripotent stem cell-derived endothelial cell type (iPSC-EC) cultured within engineered platforms that mimic the 3D microenvironment. The iPSC-ECs used here were first characterized by expression of endothelial markers and functional properties that included VEGF responsiveness, TNF-α-induced upregulation of cell adhesion molecules (MCAM/CD146; ICAM1/CD54), thrombin-dependent barrier function, shear stress-induced alignment, and 2D and 3D capillary-like network formation in Matrigel. The iPSC-ECs also formed 3D vascular networks in a variety of engineering contexts, yielded perfusable, interconnected lumen when co-cultured with primary human fibroblasts, and aligned with flow in microfluidics devices. iPSC-EC function during tubule network formation, barrier formation, and sprouting was consistent with that of primary ECs, and the results suggest a VEGF-independent mechanism for sprouting, which is relevant to therapeutic anti-angiogenesis strategies. Our combined results demonstrate the feasibility of using a well-defined, stable source of iPSC-ECs to model blood vessel formation within a variety of contexts using standard in vitro formats.National Institutes of Health (U.S.) (NIH 1UH2 TR000506-01)National Institutes of Health (U.S.) (3UH2 TR000506-02S1)National Institutes of Health (U.S.) (T32 HL007936-12)National Institutes of Health (U.S.) (RO1 HL093282)National Institutes of Health (U.S.) (R21 EB016381-01