The Effect of Intermittent Fasting and Caloric Restricted Diet on Diabetic Rats

The present study was aimed to investigate the effect of intermittent fasting and caloric restricted diet (RD) for 8 weeks on diabetic rats. Forty-nine adult male albino rats were divided into two main groups; the first main group was fed only on basal diet and served as negative control group and the second main group: diabetic rats were induced by a single intra-peritoneal injection of freshly prepared STZ (60 mg/kg BW) then divided into 6 subgroups: Subgroup (1) was fed only on basal diet and was served as positive cont. Subgroup (2) was fed on RD only. Subgroups (3, 4) were fed on basal diet and were deprived of food except water from 5 p.m. to 8 a.m. twice a week and every other day, respectively. Subgroups (5, 6): were fed on RD and intermittent fasting twice a week and every other day, respectively. The results indicated that RD and intermittent fasting significantly decreased the final body weight, feed intake and body weight gain % values as compared to the positive control rats. Diabetic treated rats had significant increase (p<0.05) in insulin concentration and lower glucose levels as well as an improvement in liver functions and lipid profile as compared to the positive control group. Conclusion: the findings suggest that intermittent fasting and caloric restricted diet could have a potential role in managing diabetes

The Effect of Some Animal and Plant Proteins on uric acid index in Rats with Acute Renal Failure

Kidney diseases are a public health problem all over the world. From recent studies it has been found that a low-protein diet as part of diet therapy has beneficial effects that slow the progression of chronic kidney disease. So, this study was carried out to investigate the uric acid index of some animal protein (Beef, eggs, kidney) and plant protein (mushroom, yellow lentils, lupine) in rats with induced-acute renal failure (ARF). Forty rats were divided into 8 groups (n=5) in each group. The first group of rats was fed on basal diet. The other rats were injected with one dose of 50% glycerol (10 ml/kg B.Wt.) in their hind limbs to induce ARF, these rats were divided into 7 subgroups, as follows: Subgroup (1): Rats with ARF were fed on basal diet supplemented with 150 gm/kg casein as positive control group (+Ve). From subgroups (2 : 7) rats were fed on the basal diet supplemented with 150 gm/kg from dried beef, eggs, kidney, mushroom, yellow lentils, lupine, respectively for 4 weeks. The treated groups with either animal or plant proteins had a significant decrease (P<0.05) in the level of kidney functions as well as lowering the mean values of phosphorous, sodium and potassium. The level of serum albumin and total protein were significantly (P<0.05) increased as compared to the +ve control group. It could be concluded that a diet containing animal protein (beef, eggs, kidney) or plant protein (mushroom, yellow lentils, lupine) may be used as a part of diet therapy to slow the progression of kidney disease and improve the kidney functions

The effective role of vitamin D and omega-3 on rats with induced Crohn’s disease

Crohn's disease is an irreversible inflammatory disease, mainly affecting the gastrointestinal tract. The aim of present study was to investigate the effect of dietary vitamin D and omega 3 supplementation on rats with induced Crohn’s disease. Twenty – four adult male albino rats weighing (160 gm) were divided into 4 groups. The 1st group (n=6) was fed on the basal diet. The 2nd to 4th of rats (n=18) were injected with (10 mg/kg for 3 days) of indomethacin at the end of the experiment to induce Crohn’s disease. Groups (3 and 4) were fed on basal diet and given orally 1000/IU/kg/ b.w. of vitamin D and 600 mg/kg/b.w. of omega 3 respectively. At the end of the experimental period (8 weeks), rats were scarified. Biochemical analysis of the tested parameters was determined. The Results indicated that indomethacin Crohn’s rats showed a significant (P< 0.05) decrease in serum albumin, serum Catalase and serum Glutathione peroxidase compared to the negative control one, while serum liver function, MDA, CRP, and immunity proteins were significantly increased.&nbsp

Effect of psyllium seeds and its husk on hypercholesterolemic rats

This study was performed to investigate the outcome of psyllium seeds and their husk on lipid profile for 8 weeks of hypercholesterolemic rats. A number of 36 mature male rats were split into two groups. The first six rats in the study were fed a standard diet (served as – ve control group). The second main group (30 rats) was fed on high cholesterol diet to induce hypercholesterolemia for six weeks, then was divided as follows: Subcategories (1) was fed on a diet with high cholesterol (as a positive control group). Subcategories (2 and 3) were on a diet with high cholesterol supplemented with 2.5% and 5% Psyllium husk powder, respectively. Subcategories (4 and 5) were fed on high cholesterol diet supplemented with 2.5 % and 5% Psyllium seed powder, respectively. The results revealed that liver functions were found to be significantly decreased (P<0.05) by Psyllium husk or seeds at the tested levels. Serum kidney functions and lipid profile were appreciably (P<0.05) decreased. At the same time, HDL-C was noticeably increased by psyllium seeds or husk supplementation at the tested levels in comparison to the positive control group

Effect of grilled meat supplemented with cinnamon, green coffee and cardamom on serum liver function of obese rats

Obesity has become a global epidemic, and it is a major risk factor for other metabolic disorders such as type 2 diabetes and cardiometabolic disease. Dietary protein is effective for body-weight management. This study aimed to   investigate the effect of grilled meat supplemented with cinnamon, green coffee and cardamom on serum liver function of obese rats. Fourty-two adult male rats weighing approximately (150 ± 5 g.) fed on basal diet for one week for adaptation. After this week rats divided into two main groups; the first main group (6 rats) fed on basal diet (as a control negative group), The second main group (36 rat) fed on high fat diet for four weeks then divided as follows: Subgroup (1) fed on high fat diet (as a control positive group). Subgroups (2) fed on high fat diet containing half amount of protein from grilled meat without any supplementation. Subgroups (3) fed on high fat diet containing half amount of protein from grilled meat supplemented with 5% cinnamon. Subgroups (4) fed on high fat diet containing half amount of protein from grilled meat with 5% green coffee.&nbsp

Effect of Psyllium Seeds and Its Husk on Hypercholesterolemic Rats

This study was performed to investigate the outcome of psyllium seeds and their husk on lipid profile for 8 weeks of hypercholesterolemic rats. A number of 36 mature male rats were split into two groups. The first six rats in the study were fed a standard diet (served as – ve control group). The second main group (30 rats) was fed on high cholesterol diet to induce hypercholesterolemia for six weeks, then was divided as follows: Subcategories (1) was fed on a diet with high cholesterol (as a positive control group). Subcategories (2 and 3) were on a diet with high cholesterol supplemented with 2.5% and 5% Psyllium husk powder, respectively. Subcategories (4 and 5) were fed on high cholesterol diet supplemented with 2.5 % and 5% Psyllium seed powder, respectively. The results revealed that liver functions were found to be significantly decreased (P<0.05) by Psyllium husk or seeds at the tested levels. Serum kidney functions and lipid profile were appreciably (P<0.05) decreased. At the same time, HDL-C was noticeably increased by psyllium seeds or husk supplementation at the tested levels in comparison to the positive control group