On Pole Assignment and Stabilizability of Neutral Type Systems

In this note we present a systematic approach to the stabilizability problem of linear infinite-dimensional dynamical systems whose infinitesimal generator has an infinite number of instable eigenvalues. We are interested in strong non-exponential stabilizability by a linear feed-back control. The study is based on our recent results on the Riesz basis property and a careful selection of the control laws which preserve this property. The investigation may be applied to wave equations and neutral type delay equations

Blepharophimosis, ptosis, epicanthus inversus syndrome type 2 with red hair, lymphedema of lower limbs and kidney stones in an Egyptian patient

We report the case of a 2 month old male, 6th in order of birth of 1st cousin consanguineous marriage with the typical features of blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) including bilateral shortening of the horizontal and vertical dimensions of the palpebral fissures, bilateral eye lids drooping, lateral displacement of inner canthi with a small skin-fold obscuring the inner canthus of the eye. Our patient had normal psychomotor development. His father was similarly affected suggesting autosomal dominant inheritance. The patient had red brown hair, lymphedema of lower limbs and kidney stones which were not reported before with this syndrome. Most probably these additional features are associations with BPES

Self-consistent determination of proton and nuclear PDFs at the Electron Ion Collider

We quantify the impact of unpolarized lepton-proton and lepton-nucleus inclusive deep-inelastic scattering (DIS) cross section measurements from the future Electron-Ion Collider (EIC) on the proton and nuclear parton distribution functions (PDFs). To this purpose, we include neutral- and charged-current DIS pseudodata in a self-consistent set of proton and nuclear global PDF determinations based on the NNPDF methodology. We demonstrate that the EIC measurements will reduce the uncertainty of the light quark PDFs of the proton at large values of the momentum fraction x and, more significantly, of the quark and gluon PDFs of heavy nuclei, especially at small and large x. We illustrate the implications of the improved precision of nuclear PDFs for the interaction of ultrahigh energy cosmic neutrinos with matter

Self-consistent determination of proton and nuclear PDFs at the Electron Ion Collider

We quantify the impact of unpolarized lepton-proton and lepton-nucleus inclusive deep-inelastic scattering (DIS) cross section measurements from the future Electron-Ion Collider (EIC) on the proton and nuclear parton distribution functions (PDFs). To this purpose we include neutral- and charged-current DIS pseudodata in a self-consistent set of proton and nuclear global PDF determinations based on the NNPDF methodology. We demonstrate that the EIC measurements will reduce the uncertainty of the light quark PDFs of the proton at large values of the momentum fraction $x$, and, more significantly, of the quark and gluon PDFs of heavy nuclei, especially at small and large $x$. We illustrate the implications of the improved precision of nuclear PDFs for the interaction of ultra-high energy cosmic neutrinos with matter.Comment: 11 pages, 5 figures, In the context of the Electron-Ion collider yellow repor

STEPS-T Program Improves Endovascular Treatment Outcomes of Acute Ischemic Stroke; A 6-Year Study

Background: Early endovascular recanalization of occluded vessels in acute ischemic stroke (AIS) is a major contributor to good clinical outcome. We report the analysis of all AIS patients throughout a 6-year experience following the deployment of a quality initiative aiming at improving care, speed and maintaining quality for AIS treatment. Methods: Using a prospectively collected endovascular database at a comprehensive stroke center between 2012 and 2017, workflow/outcomes were recorded. There were no exclusion criteria. During the first year, a quality program employing “digital-object” technology, staff education, and workflow improvement was implemented to reduce time-to-treatment. Using electronic recording, workflow times were collected for onset (TO), CT (TCT), door (TD), angiography-suite (TA), groin puncture (TG), DSA (TDSA), and recanalization (TR). Recanalization time (TG-TR) and workflow intervals were compared at Year 1 and 6. Results: Analysis of 382 patients (aged 71.3 ± 12.9) undergoing mechanical thrombectomy for AIS (206 male and 176 female) was performed. Recanalization time was significantly reduced from 82min in 2012 to 34min by 2017 (IQR 52–117min and 23–49min), a 59% reduction (P \u3c 0.001). Further, consistent year-over-year reductions in setup time (TA-TG) (44% improvement) and TCT to TA times were observed. During the same period, clinical outcome significantly improved year-over-year as measured with the modified Rankin Scale 0–2 (33, 37, 38, 41, 53, and 58%). Conclusions: Significant improvements were observed following the deployment of a quality initiative enabling iterative evidence-based process improvements, thereby sustaining significant reductions in time-to-treat and improved clinical outcomes for AIS patients

Initial Experience With the Next-Generation Resolute Onyx Zotarolimus-Eluting Stent in Symptomatic Intracranial Atherosclerotic Disease

Background and Purpose: Intracranial atherosclerotic disease (ICAD) is a common cause of stroke worldwide. Although there are different endovascular options for the treatment of symptomatic ICAD (sICAD), it is still controversial. Herein, we aim to study the safety and efficacy of a new generation of drug-eluting balloon-mounted stent (DES); Resolute (R) onyx DES in the treatment of sICAD. Methods:A prospectively maintained neuroendovascular procedures database in a high-volume comprehensive stroke center was reviewed from October 2019 through January 2020. Patients were included if they had sICAD (≥70% stenosis), failed medical management, and underwent intracranial stenting with R-onyx DES. Technical success was defined as the ability to deploy the device at the desired location and achievement of Results: A total of 18 consecutive patients (mean age, 66.6 years; 44.4% were females and 94.4% were Hispanic) were eligible for the analysis. Indication for treatment was recurrent strokes in 13 and recurrent transient ischemic attack (TIA) in 5. A total of 22 symptomatic lesions with a mean baseline stenosis percent (84.9 ± 9.6) were treated using 23 R-onyx DES in 19 procedures. All procedures were done under general anesthesia with 100% technical success, and no reported periprocedural strokes or death. Among 13 patients who had clinical follow-up, 1 (7.7%) patient had TIA. There were no reported ischemic or hemorrhagic strokes. Angiographic follow-up for 9 (50%) patients showed no in-stent restenosis. Conclusion: The use of R-onyx DES in the treatment of sICAD is safe with high technical success rates. Large prospective multicenter trials with long-term follow-up are warranted

On exact controllability of linear time delay systems of neutral type

The problem of exact null controllability is considered for linear neutral type systems with distributed delay. A characterization of this problem is given. The minimal time of controllability is precised. The results are based on the analysis of the Riesz basis property of eigenspaces in Hilbert space. Recent results on the moment problem and properties of exponential families are used