544 research outputs found
Persistence-driven durotaxis: Generic, directed motility in rigidity gradients
Cells move differently on substrates with different elasticities. In
particular, the persistence time of their motion is higher on stiffer
substrates. We show that this behavior will result in a net transport of cells
directed up a soft-to-stiff gradient. Using simple random walk models with
controlled persistence and stochastic simulations, we characterize this
propensity to move in terms of the durotactic index measured in experiments. A
one-dimensional model captures the essential features of this motion and
highlights the competition between diffusive spreading and linear, wavelike
propagation. Since the directed motion is rooted in a non-directional change in
the behavior of individual cells, the motility is a kinesis rather than a
taxis. Persistence-driven durokinesis is generic and may be of use in the
design of instructive environments for cells and other motile, mechanosensitive
objects.Comment: 5 pages, 4 figure
Matrix elasticity in vitro controls muscle stem cell fate in vivo
Almost every laboratory that grows mammalian cells today grows their cells on tissue culture plastic, which was introduced to cell culture decades ago based on properties such as inertness, transparency, and so forth. However, plastic is rigid and unlike the many soft tissues in the body. Polymer gel systems that mimic the softness of various tissues have been developed over the past decade to test and understand the effects of rigidity on cells such as muscle cells. One recent study even shows that muscle stem cells expand much better in vitro on muscle-mimetic gels and that such cells prove optimal for engraftment in muscle
The Vehicle, Spring 2000
Vol. 41, No. 2
Table of Contents
UntitledMatthew A. Thomaspage 4
Fred\u27s PenAutumn Williamspage 5
tomatoesDave Moutraypage 6
AFRICABusinge Roger Godfreypage 7
seeking OutKim Hunterpage 8
Razorblade, Crystal I.Jason Brownpage 9
UntitledMegan Guernseypage 10
CoyoteAutumn Williamspage 11
BaptizedStephanie Carpenterpage 13
BrotherTara Coburnpage 14
My 1984Dave Moutraypage 15
what little boys and girls are made ofKristi Brownfieldpage 17
To GerriMegan Guernseypage 19
JunieJoe Raabpage 20
BeatWes Paytonpage 21
MercyAutumn Williamspage 23
TravelingDenise Fitzerpage 24
UntitledMatthew A. Thomaspage 25
a story of rapeAnnie Whitepage 26
Teddy RhexisPaul Austerpage 30https://thekeep.eiu.edu/vehicle/1074/thumbnail.jp
The Vehicle, Spring 2000
Vol. 41, No. 2
Table of Contents
UntitledMatthew A. Thomaspage 4
Fred\u27s PenAutumn Williamspage 5
tomatoesDave Moutraypage 6
AFRICABusinge Roger Godfreypage 7
seeking OutKim Hunterpage 8
Razorblade, Crystal I.Jason Brownpage 9
UntitledMegan Guernseypage 10
CoyoteAutumn Williamspage 11
BaptizedStephanie Carpenterpage 13
BrotherTara Coburnpage 14
My 1984Dave Moutraypage 15
what little boys and girls are made ofKristi Brownfieldpage 17
To GerriMegan Guernseypage 19
JunieJoe Raabpage 20
BeatWes Paytonpage 21
MercyAutumn Williamspage 23
TravelingDenise Fitzerpage 24
UntitledMatthew A. Thomaspage 25
a story of rapeAnnie Whitepage 26
Teddy RhexisPaul Austerpage 30https://thekeep.eiu.edu/vehicle/1074/thumbnail.jp
Indications for thyroid FNA and pre-FNA requirements: A synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference
The National Cancer Institute (NCI) sponsored the NCI Thyroid Fine-Needle Aspiration (FNA) State of the Science Conference on October 22–23, 2007 in Bethesda, MD. The 2-day meeting was accompanied by a permanent informational website and several on-line discussions between May 1 and December 15, 2007 ( http://thyroidfna.cancer.gov ). This document summarizes the indications for performing an FNA of a nodule discovered by physical examination or an imaging study; the indications for using ultrasound versus palpation for guidance when performing a thyroid FNA; the issues surrounding informed consent for thyroid FNA; and the information required on a requisition form that accompanies a thyroid FNA specimen. ( http://thyroidfna.cancer.gov/pages/info/agenda/ ) Diagn. Cytopathol. 2008;36:390–399. © 2008 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/58658/1/20827_ftp.pd
Duke Surgery Patient Safety: an open-source application for anonymous reporting of adverse and near-miss surgical events
BACKGROUND: Studies have shown that 4% of hospitalized patients suffer from an adverse event caused by the medical treatment administered. Some institutions have created systems to encourage medical workers to report these adverse events. However, these systems often prove to be inadequate and/or ineffective for reviewing the data collected and improving the outcomes in patient safety. OBJECTIVE: To describe the Web-application Duke Surgery Patient Safety, designed for the anonymous reporting of adverse and near-miss events as well as scheduled reporting to surgeons and hospital administration. SOFTWARE ARCHITECTURE: DSPS was developed primarily using Java language running on a Tomcat server and with MySQL database as its backend. RESULTS: Formal and field usability tests were used to aid in development of DSPS. Extensive experience with DSPS at our institution indicate that DSPS is easy to learn and use, has good speed, provides needed functionality, and is well received by both adverse-event reporters and administrators. DISCUSSION: This is the first description of an open-source application for reporting patient safety, which allows the distribution of the application to other institutions in addition for its ability to adapt to the needs of different departments. DSPS provides a mechanism for anonymous reporting of adverse events and helps to administer Patient Safety initiatives. CONCLUSION: The modifiable framework of DSPS allows adherence to evolving national data standards. The open-source design of DSPS permits surgical departments with existing reporting mechanisms to integrate them with DSPS. The DSPS application is distributed under the GNU General Public License
Upper limits on the strength of periodic gravitational waves from PSR J1939+2134
The first science run of the LIGO and GEO gravitational wave detectors
presented the opportunity to test methods of searching for gravitational waves
from known pulsars. Here we present new direct upper limits on the strength of
waves from the pulsar PSR J1939+2134 using two independent analysis methods,
one in the frequency domain using frequentist statistics and one in the time
domain using Bayesian inference. Both methods show that the strain amplitude at
Earth from this pulsar is less than a few times .Comment: 7 pages, 1 figure, to appear in the Proceedings of the 5th Edoardo
Amaldi Conference on Gravitational Waves, Tirrenia, Pisa, Italy, 6-11 July
200
Improving the sensitivity to gravitational-wave sources by modifying the input-output optics of advanced interferometers
We study frequency dependent (FD) input-output schemes for signal-recycling
interferometers, the baseline design of Advanced LIGO and the current
configuration of GEO 600. Complementary to a recent proposal by Harms et al. to
use FD input squeezing and ordinary homodyne detection, we explore a scheme
which uses ordinary squeezed vacuum, but FD readout. Both schemes, which are
sub-optimal among all possible input-output schemes, provide a global noise
suppression by the power squeeze factor, while being realizable by using
detuned Fabry-Perot cavities as input/output filters. At high frequencies, the
two schemes are shown to be equivalent, while at low frequencies our scheme
gives better performance than that of Harms et al., and is nearly fully
optimal. We then study the sensitivity improvement achievable by these schemes
in Advanced LIGO era (with 30-m filter cavities and current estimates of
filter-mirror losses and thermal noise), for neutron star binary inspirals, and
for narrowband GW sources such as low-mass X-ray binaries and known radio
pulsars. Optical losses are shown to be a major obstacle for the actual
implementation of these techniques in Advanced LIGO. On time scales of
third-generation interferometers, like EURO/LIGO-III (~2012), with
kilometer-scale filter cavities, a signal-recycling interferometer with the FD
readout scheme explored in this paper can have performances comparable to
existing proposals. [abridged]Comment: Figs. 9 and 12 corrected; Appendix added for narrowband data analysi
Search for gravitational wave bursts in LIGO's third science run
We report on a search for gravitational wave bursts in data from the three
LIGO interferometric detectors during their third science run. The search
targets subsecond bursts in the frequency range 100-1100 Hz for which no
waveform model is assumed, and has a sensitivity in terms of the
root-sum-square (rss) strain amplitude of hrss ~ 10^{-20} / sqrt(Hz). No
gravitational wave signals were detected in the 8 days of analyzed data.Comment: 12 pages, 6 figures. Amaldi-6 conference proceedings to be published
in Classical and Quantum Gravit
Quantum state preparation and macroscopic entanglement in gravitational-wave detectors
Long-baseline laser-interferometer gravitational-wave detectors are operating
at a factor of 10 (in amplitude) above the standard quantum limit (SQL) within
a broad frequency band. Such a low classical noise budget has already allowed
the creation of a controlled 2.7 kg macroscopic oscillator with an effective
eigenfrequency of 150 Hz and an occupation number of 200. This result, along
with the prospect for further improvements, heralds the new possibility of
experimentally probing macroscopic quantum mechanics (MQM) - quantum mechanical
behavior of objects in the realm of everyday experience - using
gravitational-wave detectors. In this paper, we provide the mathematical
foundation for the first step of a MQM experiment: the preparation of a
macroscopic test mass into a nearly minimum-Heisenberg-limited Gaussian quantum
state, which is possible if the interferometer's classical noise beats the SQL
in a broad frequency band. Our formalism, based on Wiener filtering, allows a
straightforward conversion from the classical noise budget of a laser
interferometer, in terms of noise spectra, into the strategy for quantum state
preparation, and the quality of the prepared state. Using this formalism, we
consider how Gaussian entanglement can be built among two macroscopic test
masses, and the performance of the planned Advanced LIGO interferometers in
quantum-state preparation
- …