Electron Transfer-oxy Radical Mechanism for Anti-cancer Agents: 9-anilinoacridines

A possible mode of action involving electron transfer is advanced for the 9- anilinoacridines. The mechanism entails formation of toxic oxy radicals which destroy the neoplasm. Cyclic voltammetry was performed on iminium type ions derived by protonation of the acridines. Reductions were generally reversible with potentials of about - 0.60 V. Involvement of quinoidal metabolites is also a possibility. The relationship of electrochemical behavior to structure and physiological activity is addressed

SONTRAC—a scintillating plastic fiber tracking detector for neutron and proton imaging spectroscopy

SONTRAC (SOlar Neutron TRACking imager and spectrometer) is a conceptual instrument intended to measure the energy and incident direction of 20–150 MeV neutrons produced in solar flares. The intense neutron background in a low-Earth orbit requires that imaging techniques be employed to maximize an instrument’s signal-to-noise ratio. The instrument is comprised of mutually perpendicular, alternating layers of parallel, scintillating, plastic fibers that are viewed by optoelectronic devices. Two stereoscopic views of recoil proton tracks are necessary to determine the incident neutron’s direction and energy. The instrument can also be used as a powerful energetic proton imager. Data from a fully functional 3-d prototype are presented. Early results indicate that the instrument’s neutron energy resolution is approximately 10% with the neutron incident direction determined to within a few degrees

Partial breakdown of quantum thermalization in a Hubbard-like model

We study the possible breakdown of quantum thermalization in a model of itinerant electrons on a one-dimensional chain without disorder, with both spin and charge degrees of freedom. The eigenstates of this model exhibit peculiar properties in the entanglement entropy, the apparent scaling of which is modified from a "volume law" to an "area law" after performing a partial, site-wise measurement on the system. These properties and others suggest that this model realizes a new, non-thermal phase of matter, known as a quantum disentangled liquid (QDL). The putative existence of this phase has striking implications for the foundations of quantum statistical mechanics.Comment: As accepted to PR

Evidence of a Plasmoid-Looptop Interaction and Magnetic Inflows During a Solar Flare/CME Eruptive Event

Observational evidence is presented for the merging of a downward-propagating plasmoid with a looptop kernel during an occulted limb event on 2007 January 25. RHESSI lightcurves in the 9-18 keV energy range, as well as that of the 245 MHz channel of the Learmonth Solar Observatory, show enhanced nonthermal emission in the corona at the time of the merging suggesting that additional particle acceleration took place. This was attributed to a secondary episode of reconnection in the current sheet that formed between the two merging sources. RHESSI images were used to establish a mean downward velocity of the plasmoid of 12 km/s. Complementary observations from the SECCHI suite of instruments onboard STEREO-Behind showed that this process occurred during the acceleration phase of the associated CME. From wavelet-enhanced EUVI, images evidence of inflowing magnetic field lines prior to the CME eruption is also presented. The derived inflow velocity was found to be 1.5 km/s. This combination of observations supports a recent numerical simulation of plasmoid formation, propagation and subsequent particle acceleration due to the tearing mode instability during current sheet formation.Comment: 8 pages, 9 figures, ApJ (Accepted

Hard x-ray polarimeter for gamma-ray bursts and solar flares

We report on the development of a dedicated polarimeter design that is capable of studying the linear polarization of hard X-rays (50-300 keV) from gamma-ray bursts and solar flares. This compact design, based on the use of a large area position-sensitive PMT (PSPMT), is referred to as GRAPE (Gamma-RAy Polarimeter Experiment). The PSPMT is used to determine the Compton interaction location within an array of small plastic scintillator elements. Some of the photons that scatter within the plastic scintillator array are subsequently absorbed by a small centrally-located array of CsI(Tl) crystals that is read out by an independent multi-anode PMT. One feature of GRAPE that is especially attractive for studies of gamma-ray bursts is the significant off-axis response (at angles \u3e 60 degrees). The modular nature of this design lends itself toward its accomodation on a balloon or spacecraft platform. For an array of GRAPE modules, sensitivity levels below a few percent can be achieved for both gamma-ray bursts and solar flares. Here we report on the latest results from the testing of a laboratory science model

Dedicated polarimeter design for hard x-ray and soft gamma-ray astronomy

We have developed a modular design for a hard X-ray and soft gamma-ray polrimeter that we call GRAPE (Gamma RAy Polarimeter Experiment). Optimized for the energy range of 50-300 keV, the GRAPE design is a Compton polarimeter based on the use of an array of plastic scintillator scattering elements in conjunction with a centrally positioned high-Z calorimeter detector. Here we shall review the results from a laboratory model of the baseline GRAPE design. The baseline design uses a 5-inch diameter position sensitive PMT (PSPMT) for readout of the plastic scintillator array and a small array of CsI detectors for measurement of the scattered photon. An improved design, based on the use of large area multi-anode PMTs (MAPMTs), is also discussed along with plans for laboratory testing of a prototype. An array of GRAPE modules could be used as the basis for a dedicated science mission, either on a long duration balloon or on an orbital mission. With a large effective FoV, a non-imaging GRAPE mission would be ideal for studying polarization in transient sources (gamma ray bursts and solar flares). It may also prove useful for studying periodically varying sources, such as pulsars. An imaging system would improve the sensitivity of the polarization measurements for transient and periodic sources and may also permit the measurement of polarization in steady-state sources

The Development of GRAPE, a Gamma Ray Polarimeter Experiment

The measurement of hard X‐ray polarization in γ‐ray bursts (GRBs) would add yet another piece of information in our effort to resolve the true nature of these enigmatic objects. Here we report on the development of a dedicated polarimeter design with a relatively large FoV that is capable of studying hard X‐ray polarization (50–300 keV) from GRBs. This compact design, based on the use of a large area position‐sensitive PMT (PSPMT), is referred to as GRAPE (Gamma‐RAy Polarimeter Experiment). The feature of GRAPE that is especially attractive for studies of GRBs is the significant off‐axis polarization response (at angles greater than 60°). For an array of GRAPE modules, current sensitivity estimates give minimum detectable polarization (MDP) levels of a few percent for the brightest GRBs

Anti-cancer Action of Metal Complexes: Electron Transfer and Oxidative Stress?

Evidence is presented in support of an electron transfer mechanism for various metal complexes possessing anti-neoplastic properties. Cyclic voltammetry was performed on several metallocenes, bis(acetato)bis(imidazole)Cu(II), and coordination compounds (Cu or Fe) of the anti-tumor agents, bipyridine, phenanthroline, hydroxyurea, diethyldithiocarbamate, and α, α1-bis(8-hydroxyquinolin-7-yl)-4-methoxytoluene. The favorable reduction potentials ranged from +0.5 to -0.5 V. Electrochemical behavior is correlated in some cases with structure and physiological activity. Relevant literature data are discussed

Using LaX scintillator in a new low-background Compton telescope

The ability of Compton telescopes to perform imaging and spectroscopy in space depends directly on the speed and energy resolution of the calorimeter detectors in the telescope. The calorimeter detectors flown on space-borne or balloon-borne Compton telescopes have included NaI(Tl), CsI(Na), HPGe and liquid organic scintillator. By employing LaX scintillators for the calorimeter, one can take advantage of the unique speed and resolving power of the material to improve the instrument sensitivity and simultaneously enhance its spectroscopic performance and thus its imaging performance. We present a concept for a space-borne Compton telescope that employs LaX as a calorimeter and estimate the improvement in sensitivity over past realizations of Compton telescopes. With some preliminary laboratory measurements, we estimate that in key energy bands, typically corrupted with neutron-induced internal nuclear emissions, this design enjoys a twenty-fold improvement in background rejection