The ecclesiological movement and its antecedents in Devon: a study of 19th-century churches, church furnishings and church restoration in an English county

This thesis seeks to explore how the physical fabric of Devon churches reflects changing perceptions of the role of the Church in society during the 19th century; how churchmen, architects and craftsmen of the period employed architecture and liturgical planning to reflect a revived national Church with a new sense of its connection to the past, to the great ages of Christian civilisation, and a strong sense of its duty and mission to all members of society. Nineteenth-century furnishings are not well understood as an archaeological resource: they are disappearing fast as more and more churches succumb to fashionable re-ordering schemes, yet many are of high artistic quality and even the least among these artefacts reveals much about the people and the society which created them. Church interiors of all periods are precious resources in that they clearly reflect contemporary religious and social controversies. Church furnishings can powerfully embody and reveal the character of a place and people at the time of their creation. They may survive as complete period pieces, or may have accumulated incrementally, each alteration reflecting changing trends in churchmanship and the progress of archaeological and liturgical scholarship among architects, clergy and patrons. Above all, 19th-century church furnishings reveal a clear trend away from rigid social divisions towards a more egalitarian Church, inclusive of all people. We know very little about why particular styles or layouts of furnishings were chosen, which of these are uncommon or unusual, what they signified to those who chose and used them, and which were fashionable at which period. My thesis seeks to explore the impact of Victorian ‘ecclesiology’ upon Anglican churches in Devon; to explore the huge variety of types and materials employed in their creation and to show how these embody a desire on the part of Victorian churchmen and women to replace a Church of clear social distinctions and privilege with a Church which embodied and showed forth a more open mission to all members of the community. Out of 711 churches in existence in Devon during the 19th and early 20th centuries, 647 have been visited and photographically recorded by the author in person. The remaining 64 demolished or inaccessible churches have been studied, as far as possible, by documentary research and in photographic archives compiled by others

Effects of cane-and spur-retained node numbers on the pre-flowering vegetative growth of cane-pruned Sauvignon blanc

In established vineyards, node number retention at winter pruning is the first step to achieving and maintaining vine balance. Balanced vines exhibit timely and quasi-uniform 100 percent budburst. To understand how vine capacity and balance are expressed before flowering, mature Sauvignon blanc vines were pruned according to a 5 [total node numbers on canes: 10, 20, 30, 40, 50] x 3 [total node numbers on spurs: 1, 2, 3] factorial design in one site, and in two other sites according to a 5 [total node numbers on canes: 10, 20, 30, 40, 50] x 2 [total node numbers on spurs: 1, 2] factorial design. Two spurs of one, two or three nodes each were retained on either side of the vine. The number of canes laid down per vine was one, two, three and four canes each of 10 nodes for the 10-, 20-, 30-and 40-node treatments, and four canes averaging 12.5 nodes for the 50-node treatment. The budburst percentage was calculated on the whole vine, canes, and spurs. Blind nodes, count shoots, non-count shoots and double shoots were counted and mapped along canes and spurs. Many non-count shoots were measured on the vine head of 10-node vines (29.5 ± 3.0 shoots, p < 0.001), compared to 50-node vines (2.8 ± 1.9 shoots, p < 0.001). 50-node vines had an overall budburst of 100 %, despite having the highest number of blind nodes (7.6 ± 0.3 nodes, p < 0.001). These were mainly located at the canes’ proximal sections relative to the vine head and were likely caused by correlative inhibition and primary bud necrosis. Cane budburst provided a more accurate assessment of the vine response to node loading than vine budburst. The number of double shoots was not associated with the vine node load, as they appeared on both low-node and high-node vines. Three-node spurs developed more blind nodes than one-node and two-node spurs (p < 0.001). Based on the findings of this research, we recommend a composite metric (cane percent budburst, cane blind node count and head shoot count) to assess vine capacity and balance between budburst and flowering, and the practice of retaining one-or two-node spurs at cane pruning is also justified

INTERIM BARRIER AT HANFORDS TY FARM TO PROTECT GROUNDWATER AT THE HANFORD SITE WASHINGTON USA

An innovative interim surface barrier was constructed as a demonstration project at the Hanford Site's TY Tank Farm. The purpose of the demonstration barrier is to stop rainwater and snowmelt from entering the soils within the tank farm and driving contamination from past leaks and spills toward the ground water. The interim barrier was constructed using a modified asphalt material with very low permeability developed by MatCon{reg_sign}. Approximately 2,400 cubic yards of fill material were added to the tank farm to create a sloped surface that will gravity drain precipitation to collection points where it will be routed through buried drain lines to an evapotranspiration basin adjacent to the farm. The evapotranspiration basin is a lined basin with a network of perforated drain lines covered with soil and planted with native grasses. The evapotranspiration concept was selected because it prevents the runoff from percolating into the soil column and also avoids potential monitoring and maintenance issues associated with standing water in a traditional evaporation pond. Because of issues associated with using standard excavation and earth moving equipment in the farm a number of alternate construction approaches were utilized to perform excavations and prepare the site for the modified asphalt

Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility

Combining samples for genetic association is standard practice in human genetic analysis of complex traits, but is rarely undertaken in rodent genetics. Here, using 23 phenotypes and genotypes from two independent laboratories, we obtained a sample size of 3,076 commercially available outbred mice and identified 70 loci, more than double the number of loci identified in the component studies. Fine-mapping in the combined sample reduced the number of likely causal variants, with a median reduction in set size of 51%, and indicated novel gene associations, including Pnpo, Ttll6 and GM11545 with bone mineral density, and Psmb9 with weight. However replication at a nominal threshold of 0.05 between the two component studies was low, with less than a third of loci identified in one study replicated in the second. In addition to overestimates in the effect size in the discovery sample (Winner's Curse), we also found that heterogeneity between studies explained the poor replication, but the contribution of these two factors varied among traits. Leveraging these observations we integrated information about replication rates, study-specific heterogeneity, and Winner's Curse corrected estimates of power to assign variants to one of four confidence levels. Our approach addresses concerns about reproducibility, and demonstrates how to obtain robust results from mapping complex traits in any genome-wide association study

Confidentiality and public protection: ethical dilemmas in qualitative research with adult male sex offenders

This paper considers the ethical tensions present when engaging in in-depth interviews with convicted sex offenders. Many of the issues described below are similar to those found in other sensitive areas of research. However, confidentiality and public protection are matters that require detailed consideration when the desire to know more about men who have committed serious and harmful offences is set against the possibility of a researcher not disclosing previously unknown sensitive information that relates to the risk of someone being harmed.</p

Factors affecting the prey preferences of jackals (Canidae)

Prey selection by carnivores can be affected by top-down and bottom-up factors. For example, large carnivores may facilitate food resources for mesocarnivores by providing carcasses to scavenge, however mesocarnivores may hunt large prey themselves, and their diets might be affected by prey size and behaviour. We reviewed jackal diet studies and determined how the presence of large carnivores and various bottom-up factors affected jackal prey selection. We found 20 studies of black-backed jackals (Canis mesomelas) from 43 different times or places, and 13 studies of Eurasian golden jackals (Canis aureus) from 23 different times or places reporting on 3900 and 2440 dietary records (i.e. scats or stomach contents), respectively. Black-backed jackals significantly preferred small ( 120 kg) hider species and follower species of any body size. They had a preferred and accessible prey weight range of 14-26 kg, and a predator to ideal prey mass ratio of 1:3.1. Eurasian golden jackal significantly prefer to prey on brown hare (Lepus europaeus; 4 kg), yielding a predator to preferred prey mass ratio of 1:0.6, and a preferred and accessible prey weight range of 0 – 4 kg and 0 – 15 kg, respectively. Prey preferences of jackals differed significantly in the presence of apex predators, but it was not entirely due to carrion availability of larger prey species. Our results show that jackal diets are affected by both top-down and bottom-up factors, because apex predators as well as prey size and birthing behaviour affected prey preferences of jackals. A better understanding of the factors affecting jackal prey preferences, as presented here, could lead to greater acceptance of mesocarnivores and reduced human-wildlife conflict

Loss and dispersion of superficial white matter in Alzheimer's disease: a diffusion MRI study

Pathological cerebral white matter changes in Alzheimer’s disease have been shown using diffusion tensor imaging. Superficial white matter changes are relatively understudied despite their importance in cortico-cortical connections. Measuring superficial white matter degeneration using diffusion tensor imaging is challenging due to its complex organizational structure and proximity to the cortex. To overcome this, we investigated diffusion MRI changes in young-onset Alzheimer’s disease using standard diffusion tensor imaging and Neurite Orientation Dispersion and Density Imaging to distinguish between disease-related changes that are degenerative (e.g. loss of myelinated fibres) and organizational (e.g. increased fibre dispersion). Twenty-nine young-onset Alzheimer’s disease patients and 22 healthy controls had both single-shell and multi-shell diffusion MRI. We calculated fractional anisotropy, mean diffusivity, neurite density index, orientation dispersion index and tissue fraction (1-free water fraction). Diffusion metrics were sampled in 15 a priori regions of interest at four points along the cortical profile: cortical grey matter, grey/white boundary, superficial white matter (1 mm below grey/white boundary) and superficial/deeper white matter (2 mm below grey/white boundary). To estimate cross-sectional group differences, we used average marginal effects from linear mixed effect models of participants’ diffusion metrics along the cortical profile. The superficial white matter of young-onset Alzheimer’s disease individuals had lower neurite density index compared to controls in five regions (superior and inferior parietal, precuneus, entorhinal and parahippocampus) (all P < 0.05), and higher orientation dispersion index in three regions (fusiform, entorhinal and parahippocampus) (all P < 0.05). Young-onset Alzheimer’s disease individuals had lower fractional anisotropy in the entorhinal and parahippocampus regions (both P < 0.05) and higher fractional anisotropy within the postcentral region (P < 0.05). Mean diffusivity was higher in the young-onset Alzheimer’s disease group in the parahippocampal region (P < 0.05) and lower in the postcentral, precentral and superior temporal regions (all P < 0.05). In the overlying grey matter, disease-related changes were largely consistent with superficial white matter findings when using neurite density index and fractional anisotropy, but appeared at odds with orientation dispersion and mean diffusivity. Tissue fraction was significantly lower across all grey matter regions in young-onset Alzheimer’s disease individuals (all P < 0.001) but group differences reduced in magnitude and coverage when moving towards the superficial white matter. These results show that microstructural changes occur within superficial white matter and along the cortical profile in individuals with young-onset Alzheimer’s disease. Lower neurite density and higher orientation dispersion suggests underlying fibres undergo neurodegeneration and organizational changes, two effects previously indiscernible using standard diffusion tensor metrics in superficial white matter

Solar-type dynamo behaviour in fully convective stars without a tachocline

In solar-type stars (with radiative cores and convective envelopes), the magnetic field powers star spots, flares and other solar phenomena, as well as chromospheric and coronal emission at ultraviolet to X-ray wavelengths. The dynamo responsible for generating the field depends on the shearing of internal magnetic fields by differential rotation. The shearing has long been thought to take place in a boundary layer known as the tachocline between the radiative core and the convective envelope. Fully convective stars do not have a tachocline and their dynamo mechanism is expected to be very different, although its exact form and physical dependencies are not known. Here we report observations of four fully convective stars whose X-ray emission correlates with their rotation periods in the same way as in Sun-like stars. As the X-ray activity - rotation relationship is a well-established proxy for the behaviour of the magnetic dynamo, these results imply that fully convective stars also operate a solar-type dynamo. The lack of a tachocline in fully convective stars therefore suggests that this is not a critical ingredient in the solar dynamo and supports models in which the dynamo originates throughout the convection zone.Comment: 6 pages, 1 figure. Accepted for publication in Nature (28 July 2016). Author's version, including Method

Use of imaging for pre- and post-operative characterisation of ventral hernia: systematic review

OBJECTIVE: Complex ventral hernia repair is performed increasingly, exacerbated by the obesity epidemic. Imaging can characterise hernia morphology and diagnose recurrence. By systematic review we investigated the extent to which studies employ imaging. METHODS: The PubMed database was searched for studies of ventral hernia repair January 1995 to March 2016. Hernias of all size were eligible. Independent reviewers screened articles and extracted data from selected studies related to study design, use of pre- and post-operative hernia imaging, and the proportion of subjects imaged. The review was registered: PROSPERO CRD42016043071. RESULTS: 15,771 records were identified initially. 174 full-texts were examined and 158 ultimately included in the systematic review (31 randomised-controlled-trials; 32 cohort studies; 95 retrospective cohort studies). 31,874 subjects were reported overall. Only 19 (12%) studies employed pre-operative imaging for hernia characterisation and 46 (29%) post-operatively [equating to 511 (2%) of all preoperative subjects and 1123 (4%) post-operative]. Furthermore, most studies employing imaging did not do so in all subjects: Just six (4%) of the 158 studies used imaging in all subjects preoperatively and just 4 (3%) postoperatively, i.e. imaging was usually applied to a proportion of patients only. Moreover, the exact proportion was frequently not specified. Studies using imaging frequently stated that "imaging", "radiography" or "radiology" was used but did not specify the modality precisely nor the proportion of subjects imaged. CONCLUSION: Despite the ability to characterise ventral hernia morphology and recurrence with precision, most indexed studies do not employ imaging. Where imaging is used, data are often reported incompletely. Advances in knowledge: (1) This systematic review is the first to focus on the use of imaging in surgical studies of ventral hernia repair. (2) Studies of ventral hernia repair rarely use imaging, either to characterise hernias preoperatively or to diagnose recurrence, despite the latter being the primary outcome of most studies. (3) Failure to use imaging will result in incomplete hernia characterisation and underestimate recurrence rates in studies of surgical repair

Cortical microstructure in young onset Alzheimer's disease using neurite orientation dispersion and density imaging

Alzheimer's disease (AD) is associated with extensive alterations in grey matter microstructure, but our ability to quantify this in vivo is limited. Neurite orientation dispersion and density imaging (NODDI) is a multi-shell diffusion MRI technique that estimates neuritic microstructure in the form of orientation dispersion and neurite density indices (ODI/NDI). Mean values for cortical thickness, ODI, and NDI were extracted from predefined regions of interest in the cortical grey matter of 38 patients with young onset AD and 22 healthy controls. Five cortical regions associated with early atrophy in AD (entorhinal cortex, inferior temporal gyrus, middle temporal gyrus, fusiform gyrus, and precuneus) and one region relatively spared from atrophy in AD (precentral gyrus) were investigated. ODI, NDI, and cortical thickness values were compared between controls and patients for each region, and their associations with MMSE score were assessed. NDI values of all regions were significantly lower in patients. Cortical thickness measurements were significantly lower in patients in regions associated with early atrophy in AD, but not in the precentral gyrus. Decreased ODI was evident in patients in the inferior and middle temporal gyri, fusiform gyrus, and precuneus. The majority of AD-related decreases in cortical ODI and NDI persisted following adjustment for cortical thickness, as well as each other. There was evidence in the patient group that cortical NDI was associated with MMSE performance. These data suggest distinct differences in cortical NDI and ODI occur in AD and these metrics provide pathologically relevant information beyond that of cortical thinning