μlED-Based Single-Wavelength Bi-directional POF Link with 10 Gb/s Aggregate Data Rate

We report record 10 Gb/s bi-directional data transmission over a single 10 m SI-POF, by employing blue micro-light-emitting diodes (μLEDs) at a single wavelength, APD receivers and a PAM-32 modulation scheme. The implementation of 10 Gb/s LED-POF links takes advantage of the bi-directional configuration, which doubles the overall channel capacity, and APDs which provide an enhanced link power budget owing to their improved sensitivity compared with conventional PIN photodiodes. Moreover, the high spectral efficiency of the PAM-32 modulation scheme employed, together with equalization techniques, enable the full utilization of the link bandwidth and the transmission of data rates higher than those obtained with conventional on-off-keying (OOK). Simulation and experimental results demonstrate the feasibility of such a bi-directional link and simultaneous 5 Gb/s data transmission is realized in each direction, achieving an aggregate data rate of 10 Gb/s with a BER<10-3. The crosstalk penalty between the two directions of the link is measured to be less than 0.5 dB.This is the final version of the article. It first appeared from IEEE via http://dx.doi.org/10.1109/JLT.2015.244398

2 Gb/s μlED-APD based visible light communications using feed-forward pre-equalization and PAM-4 modulation

Feed-forward pre-equalization is investigated to extend the transmission capability of μLED-based links, providing better receiver sensitivities up to 5dB compared with post-equalization. Error-free 2Gb/s free-space VLC over 0.6m is demonstrated using a PAM-4 modulated blue μLED and an APD receiver.This work is supported by the UK EPSRC via the UPVLC Project.This is the author accepted manuscript. The final version is available from IEEE via http://dx.doi.org/10.1109/ECOC.2015.734188

6.25 Gb/s POF link using GaN μLED arrays and optically generated pulse amplitude modulation

Optically-generated PAM schemes using μLED arrays are implemented for high-speed POF links for the first time. 6.25Gb/s PAM-16 transmission is demonstrated using 4 μLEDs, exhibiting 3.8dB greater power-margin than a link with a single μLED.This work is supported by the UK Engineering and Physical Sciences Research Council (EPSRC) via the Ultra Parallel Visible Light Communication (UP-VLC) Project.This is the accepted manuscript of a paper published in CLEO: 2015 (X. Li, N. Bamiedakis, J. Wei, J. Mckendry, E. Xie, R. Ferreira, E. Gu, M. Dawson, R. V. Penty, and I. H. White, "6.25 Gb/s POF Link Using GaN μLED Arrays and Optically Generated Pulse Amplitude Modulation," in CLEO: 2015, OSA Technical Digest (online) (Optical Society of America, 2015), paper STu4F.7.). The final version is available at http://dx.doi.org/10.1364/CLEO_SI.2015.STu4F.7 © 2015 Optical Society of America. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modifications of the content of this paper are prohibited

High Bandwidth GaN-Based Micro-LEDs for Multi-Gb/s Visible Light Communications

Gallium-nitride (GaN) based light-emitting diodes (LEDs) are highly-efficient sources for general purpose illumination. Furthermore, being semiconductor-based light sources, they are readily compatible with intelligent drive electronics. Visible light communications (VLC) is a technology which leverages these advantageous properties of GaN LEDs and can supplement existing wireless communications by offering a large, licence-free spectral bandwidth. Here we report on progress in the development of micro-scale GaN LEDs (micro-LEDs), optimised for VLC. These blue-emitting micro-LEDs are shown to have very high electrical-to-optical modulation bandwidths, exceeding 800~MHz. The data transmission capabilities of the micro-LEDs are illustrated by demonstrations using on-off-keying (OOK), pulse-amplitude modulation (PAM) and orthogonal frequency division multiplexing (OFDM) modulation schemes to transmit data over free space at rates of 1.7, 3.4 and 5 Gb/s, respectively

Wide spectrum of NR5A1-related phenotypes in 46,XY and 46,XX individuals

Steroidogenic factor 1 (NR5A1, SF-1, Ad4BP) is a transcriptional regulator of genes involved in adrenal and gonadal development and function. Mutations in NR5A1 have been among the most frequently identified genetic causes of gonadal development disorders and are associated with a wide phenotypic spectrum. In 46,XY individuals, NR5A1-related phenotypes may range from disorders of sex development (DSD) to oligo/azoospermia, and in 46,XX individuals, from 46,XX ovotesticular and testicular DSD to primary ovarian insufficiency (POI). The most common 46,XY phenotype is atypical or female external genitalia with clitoromegaly, palpable gonads, and absence of Müllerian derivatives. Notably, an undervirilized external genitalia is frequently seen at birth, while spontaneous virilization may occur later, at puberty. In 46,XX individuals, NR5A1 mutations are a rare genetic cause of POI, manifesting as primary or secondary amenorrhea, infertility, hypoestrogenism, and elevated gonadotropin levels. Mothers and sisters of 46,XY DSD patients carrying heterozygous NR5A1 mutations may develop POI, and therefore require appropriate counseling. Moreover, the recurrent heterozygous p.Arg92Trp NR5A1 mutation is associated with variable degrees of testis development in 46,XX patients. A clear genotype-phenotype correlation is not seen in patients bearing NR5A1 mutations, suggesting that genetic modifiers, such as pathogenic variants in other testis/ovarian-determining genes, may contribute to the phenotypic expression. Here, we review the published literature on NR5A1-related disease, and discuss our findings at a single tertiary center in Brazil, including ten novel NR5A1 mutations identified in 46,XY DSD patients. The ever-expanding phenotypic range associated with NR5A1 variants in XY and XX individuals confirms its pivotal role in reproductive biology, and should alert clinicians to the possibility of NR5A1 defects in a variety of phenotypes presenting with gonadal dysfunction

The C2HDM revisited

The complex two-Higgs doublet model is one of the simplest ways to extend the scalar sector of the Standard Model to include a new source of CP-violation. The model has been used as a benchmark model to search for CP-violation at the LHC and as a possible explanation for the matter-antimatter asymmetry of the Universe. In this work, we re-analyse in full detail the softly broken $\mathbb{Z}_2$ symmetric complex two-Higgs doublet model (C2HDM). We provide the code C2HDM_HDECAY implementing the C2HDM in the well-known HDECAY program which calculates the decay widths including the state-of-the-art higher order QCD corrections and the relevant off-shell decays. Using C2HDM_HDECAY together with the most relevant theoretical and experimental constraints, including electric dipole moments (EDMs), we review the parameter space of the model and discuss its phenomenology. In particular, we find cases where large CP-odd couplings to fermions are still allowed and provide benchmark points for these scenarios. We examine the prospects of discovering CP-violation at the LHC and show how theoretically motivated measures of CP-violation correlate with observables.The work of D.F., J.C.R. and J.P.S. is supported in part by the Portuguese Fundacao para a Ciencia e Tecnologia (FCT) under contracts CERN/FIS-NUC/0010/2015 and UID/FIS/00777/2013. MM acknowledges financial support from the DFG project "Precision Calculations in the Higgs Sector - Paving the Way to the New Physics Landscape" (ID: MU 3138/1-1).info:eu-repo/semantics/publishedVersio

Physiological traits of the symbiotic bacterium Teredinibacter turnerae isolated from the mangrove shipworm Neoteredo reynei

Nutrition in the Teredinidae family of wood-boring mollusks is sustained by cellulolytic/nitrogen fixing symbiotic bacteria of the Teredinibacter clade. The mangrove Teredinidae Neoteredo reynei is popularly used in the treatment of infectious diseases in the north of Brazil. In the present work, the symbionts of N. reynei, which are strictly confined to the host's gills, were conclusively identified as Teredinibacter turnerae. Symbiont variants obtained in vitro were able to grow using casein as the sole carbon/nitrogen source and under reduced concentrations of NaCl. Furthermore, cellulose consumption in T. turnerae was clearly reduced under low salt concentrations. As a point of interest, we hereby report first hand that T. turnerae in fact exerts antibiotic activity. Furthermore, this activity was also affected by NaCl concentration. Finally, T. turnerae was able to inhibit the growth of Gram-negative and Gram-positive bacteria, this including strains of Sphingomonas sp., Stenotrophomonas maltophilia, Bacillus cereus and Staphylococcus sciuri. Our findings introduce new points of view on the ecology of T. turnerae, and suggest new biotechnological applications for this marine bacterium