37 research outputs found

    The influence of persistent pathogens on circulating levels of inflammatory markers: A cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis

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    Background: Systemic inflammation is linked to cardiovascular risk, but the influence of persistent pathogens, which are conventionally dichotomously categorized, on circulating levels of inflammatory markers is not clear. Antibody levels of pathogens have not been examined in relation to inflammation. Methods. Using data from a subsample of the Multi-Ethnic Study of Atherosclerosis, we examined circulating levels of interleukin-6 (IL-6), C-reactive protein (CRP) and fibrinogen in relation to five common persistent pathogens: cytomegalovirus, herpes simplex virus-1, Hepatitis A virus, Helicobacter pylori and Chlamydia pneumoniae. We tested the hypothesis that the number of seropositive pathogens (based on conventional cut-off points) would not be as sensitive a marker of inflammation as immune response measured by antibody levels to pathogens. Results. High antibody response to multiple pathogens showed graded and significant associations with IL-6 (p < 0.001), CRP (p = 0.04) and fibrinogen (p = 0.001), whereas seropositive pathogen burden did not. In multiple linear regression models, high antibody response to multiple pathogens maintained a positive association only with IL-6 (4.4% per pathogen exhibiting high antibody response, 95% CI 0.0-8.9). Conclusions. High antibody response to pathogens was a more consistent marker of inflammatory outcomes compared to seropositivity alone and high antibody response to multiple pathogens was a stronger marker compared to any single pathogen

    Testing for consistency in the impacts of a burrowing ecosystem engineer on soil and vegetation characteristics across biomes

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    The impacts of ecosystem engineers may be expected to vary along environmental gradients. Due to some resources being more limited in arid than in mesic environments, disturbances created by burrowing mammals are expected to have a greater ameliorating effect in arid environments, with larger differences in microhabitat conditions expected between burrows and undisturbed areas. The aim of this study was to test if the impacts of a medium-sized burrowing mammal, the aardvark, on soil properties (soil temperature, moisture and compaction) and vegetation characteristics (plant cover, species richness and species composition) are consistent across three biomes that differ strongly in annual rainfall. Burrowing affected soil and vegetation attributes, but the direction and magnitude of these biogeomorphological impacts were not consistent across the different biomes. For example, plant species composition was altered by burrowing in the arid scrubland and in the mesic grassland, but not in the semi-arid savannah. Contrary to expectations, the difference in the impacts of burrowing between biomes were not related to rainfall, with burrowing having strong, albeit different, impacts in both the arid scrubland and the mesic grassland, but weaker effects in the semi-arid savannah. It appears, therefore, that the impacts of these biogeomorphic agents may be site-specific and that it may be difficult to predict variation in their biotic and abiotic effects across environmental gradients. As a result, forecasting the impacts of ecosystem engineers under different conditions remains a challenge to management, restoration and conservation strategies related to these types of species.http://www.nature.com/srepam2020Geography, Geoinformatics and MeteorologyPlant Production and Soil Scienc

    Spatial association of lemming burrows with landforms in the Swedish subarctic mountains : implications for periglacial feature stability

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    Burrowing mammals often have considerable geomorphological impacts, and their tunneling activities may decrease the stability of landforms. We document the spatial distribution of Norwegian lemming burrows in a subarctic alpine meadow to determine the preferred locations for burrow entrances and to examine the potential for burrowing to decrease the stability of periglacial landforms at the site. Burrow entrances were disproportionately common into the base and sides of landforms (.68% of burrows), probably reflecting the lower energetic cost of moving soil horizontally, rather than vertically, out of burrows. Most burrow entrances (.60%) were also located under large rocks, which probably improve burrow stability by providing a firm ceiling to the entrance. Field observations show that these burrows are relatively stable, as only 3% were associated with any signs of increased erosion or landform instability. Therefore, in contrast to some previous studies, and despite burrowing being concentrated on landforms, we suggest that these rodents have little direct impact on landform integrity at this site.South African National Research Foundation and the Swedish International Development Cooperation Agency. South African National Antarctic Program. DST-NRF Centre of Excellence for Invasion Biology.http://instaar.colorado.edu/AAAR/index.phphb2016Geography, Geoinformatics and Meteorolog

    Bariatric surgery for spontaneous ovulation in women living with polycystic ovary syndrome: the BAMBINI multicentre, open-label, randomised controlled trial

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    BackgroundPolycystic ovary syndrome (PCOS) is the most common cause of an ovulatory infertility. Obesity exacerbates the reproductive complications of PCOS; however, the management of obesity in women with PCOS remains a large unmet clinical need. Observational studies have indicated that bariatric surgery could improve the rates of ovulatory cycles and prospects of fertility; however, the efficacy of surgery on ovulation rates has not yet been compared with behavioural modifications and medical therapy in a randomised trial. The aim of this study was to compare the safety and efficacy of bariatric surgery versus medical care on ovulation rates in women with PCOS, obesity, and oligomenorrhoea or amenorrhoea.MethodsIn this multicentre, open-label, randomised controlled trial, 80 women older than 18 years, with a diagnosis of PCOS based on the 2018 international evidence-based guidelines for assessing and managing PCOS, and a BMI of 35 kg/m2 or higher, were recruited from two specialist obesity management centres and via social media. Participants were randomly assigned at a 1:1 ratio to either vertical sleeve gastrectomy or behavioural interventions and medical therapy using a computer-generated random sequence (PLAN procedure in SAS) by an independent researcher not involved with any other aspect of theclinical trial. The median age of the entire cohort was 31 years and 79% ofparticipants were White. The primary outcome was the number of biochemicallyconfirmed ovulatory events over 52 weeks, and was assessed using weekly serumprogesterone measurements. The primary endpoint included the intention-to-treatpopulation and safety analyses were per-protocol population. This study isregistered with the ISRCTN registry (ISRCTN16668711).FindingsParticipants were recruited from Feb 20, 2020 to Feb 1, 2021.40 participants were assigned to each group and there were seven dropouts in the medical group and ten dropouts in the surgical group. The median number of ovulations was 6 (IQR 3·5–10·0) in the surgical group and 2 (0·0–4·0) in the medical group. Women in the surgical group had 2.5 times more spontaneous ovulations compared with the medical group (incidence rate ratio 2·5 [95% CI1·5–4·2], p&lt;0·0007). There were more complications in the surgical group than the medical group, although without long-term sequelae. There were 24(66·7%) adverse events in the surgical group and 12 (30·0%) in the medical group. There were no treatment-related deaths.InterpretationBariatric surgery was more effective than medical care for the induction of spontaneous ovulation in women with PCOS, obesity, and oligomenorrhoea or amenorrhoea. Bariatric surgery could, therefore, enhance the prospects of spontaneous fertility in this group of women.</p

    Defining standards and core outcomes for clinical trials in prehabilitation for colorectal surgery (DiSCO): modified Delphi methodology to achieve patient and healthcare professional consensus

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    Spatial association of lemming burrows with landforms in the Swedish subarctic mountains: Implications for periglacial feature stability

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    Burrowing mammals often have considerable geomorphological impacts, and their tunneling activities may decrease the stability of landforms. We document the spatial distribution of Norwegian lemming burrows in a subarctic alpine meadow to determine the preferred locations for burrow entrances and to examine the potential for burrowing to decrease the stability of periglacial landforms at the site. Burrow entrances were disproportionately common into the base and sides of landforms (>68% of burrows), probably reflecting the lower energetic cost of moving soil horizontally, rather than vertically, out of burrows. Most burrow entrances (>60%) were also located under large rocks, which probably improve burrow stability by providing a firm ceiling to the entrance. Field observations show that these burrows are relatively stable, as only 3% were associated with any signs of increased erosion or landform instability. Therefore, in contrast to some previous studies, and despite burrowing being concentrated on landforms, we suggest that these rodents have little direct impact on landform integrity at this site. © 2011 Arctic, Antarctic, and Alpine Research.Articl

    Restoration potential of invaded abandoned agricultural fields : what does the seed bank tell us?

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    Soil seed banks can play an important role in the restoration of degraded ecosystems, especially where indigenous species are well represented in, and invasive species are largely absent from, the seed bank. Here, we studied the potential contribution of the soil seed bank to the restoration of invaded, abandoned agricultural fields in the Eastern Cape, South Africa. We recorded the aboveground cover and belowground abundance of all vascular plant species from 120 quadrats that differ in cover of the extralimital woody invader, Pteronia incana. Our results show that higher cover of P. incana is associated with lower species richness, aboveground cover, and belowground seed abundance. Furthermore, community similarity between the above‐ and belowground component was low, with the seed bank and standing vegetation having only 15 species in common and 49 species being recorded only from the seed bank. We suggest that this large number of seed bank‐only species is a relic of previous vegetation, prior to large‐scale invasion by P. incana. The most important finding from our study is the absence of P. incana from the soil seed bank. This finding, combined with the large number of mostly native species from the seed bank, holds promise from a restoration perspective. However, given the susceptibility of the invaded systems to erosion, coupled with the low grazing value of the seed bank species, we suggest that P. incana removal should be accompanied by both erosion control measures and reseeding with palatable grass species, to secure the livelihoods of local communities.The National Research Foundation of South Africa (unique grant number 94103).https://onlinelibrary.wiley.com/journal/1526100x2020-01-13hj2019Geography, Geoinformatics and MeteorologyPlant Production and Soil Scienc

    Restoration potential of invaded abandoned agricultural fields: what does the seed bank tell us?

    No full text
    Soil seed banks can play an important role in the restoration of degraded ecosystems, especially where indigenous species are well represented in, and invasive species are largely absent from, the seed bank. Here, we studied the potential contribution of the soil seed bank to the restoration of invaded, abandoned agricultural fields in the Eastern Cape, South Africa. We recorded the aboveground cover and belowground abundance of all vascular plant species from 120 quadrats that differ in cover of the extralimital woody invader, Pteronia incana. Our results show that higher cover of P. incana is associated with lower species richness, aboveground cover, and belowground seed abundance. Furthermore, community similarity between the above‐ and belowground component was low, with the seed bank and standing vegetation having only 15 species in common and 49 species being recorded only from the seed bank. We suggest that this large number of seed bank‐only species is a relic of previous vegetation, prior to large‐scale invasion by P. incana. The most important finding from our study is the absence of P. incana from the soil seed bank. This finding, combined with the large number of mostly native species from the seed bank, holds promise from a restoration perspective. However, given the susceptibility of the invaded systems to erosion, coupled with the low grazing value of the seed bank species, we suggest that P. incana removal should be accompanied by both erosion control measures and reseeding with palatable grass species, to secure the livelihoods of local communities.The National Research Foundation of South Africa (unique grant number 94103).https://onlinelibrary.wiley.com/journal/1526100x2020-01-13hj2019Geography, Geoinformatics and MeteorologyPlant Production and Soil Scienc

    Ecosystem engineering through aardvark (Orycteropus afer) burrowing : mechanisms and effects

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    Burrowing mammals are often considered to be ecosystem engineers as burrowing disturbs the soil, thereby potentially changing resource availability and affecting habitat conditions for other species. After their excavation, burrows may strongly impact local plant communities through several mechanisms, including resource trapping, altered chemical and physical soil properties, and amelioration of microclimatic conditions. We studied ecosystem engineering by aardvark (Orycteropus afer) burrowing by comparing soil and vegetation characteristics between three microsites (burrow entrances, excavated soil mounds and adjacent control sites). We were able to identify several engineering effects and distinguish between potential mechanisms. Burrow soils were cooler, drier and less compact than the other microsites, with all three microsites representing unique combinations of abiotic conditions. Mean species richness was higher at older burrows than mounds and non-burrowed controls, despite burrows having a smaller seedbank and not differing in soil fertility from mounds and control sites. However, the opposite was observed at fresh burrows and mounds, where control plots contained more species on average than the other two types of microsites. Burrow age and microsite type also affected species composition, although only a small proportion of species were significantly associated with specific microsites and just two species were limited to a single microsite type. We suggest that trampling and the physical digging action at burrow entrances, and burial by deposited soil at mounds, prevents the establishment of many plant species at active burrows. However, once abandoned, burrow entrances provide good physical conditions for seedling survival, allowing the establishment of more species. Therefore, as suggested previously for other ecosystem engineers, it is important to explicitly consider the age and degradation processes of engineered structures. In addition, our results highlight biologically-important differences in engineering impacts between burrow entrances, where soil is removed, and mounds, where soil is deposited. Such microscale differences are important to consider when examining bioturbation or, more generally, ecosystem engineering.The National Research Foundation of South Africa for Grant No. 94103.http://www.elsevier.com/locate/ecoleng2019-08-01hj2018Geography, Geoinformatics and MeteorologyPlant Production and Soil Scienc
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