665 research outputs found
Charge-imbalance effects in intrinsic Josephson systems
We report on two types of experiments with intrinsic Josephson systems made
from layered superconductors which show clear evidence of nonequilibrium
effects: 1. In 2-point measurements of IV-curves in the presence of high-
frequency radiation a shift of the voltage of Shapiro steps from the canonical
value hf/(2e) has been observed. 2. In the IV-curves of double-mesa structures
an influence of the current through one mesa on the voltage measured on the
other mesa is detected. Both effects can be explained by charge-imbalance on
the superconducting layers produced by the quasi-particle current, and can be
described successfully by a recently developed theory of nonequilibrium effects
in intrinsic Josephson systems.Comment: 8pages, 9figures, submitted to Phys. Rev.
Chlamydia infection depends on a functional âMDM2-âp53 axis
Chlamydia, a major human bacterial pathogen, assumes effective strategies to protect infected cells against death-inducing stimuli, thereby ensuring completion of its developmental cycle. Paired with its capacity to cause extensive host DNA damage, this poses a potential risk of malignant transformation, consistent with circumstantial epidemiological evidence. Here we reveal a dramatic depletion of p53, a tumor suppressor deregulated in many cancers, during Chlamydia infection. Using biochemical approaches and live imaging of individual cells, we demonstrate that p53 diminution requires phosphorylation of Murine Double Minute 2 (MDM2; a ubiquitin ligase) and subsequent interaction of phospho-MDM2 with p53 before induced proteasomal degradation. Strikingly, inhibition of the p53-MDM2 interaction is sufficient to disrupt intracellular development of Chlamydia and interferes with the pathogen's anti-apoptotic effect on host cells. This highlights the dependency of the pathogen on a functional MDM2-p53 axis and lends support to a potentially pro-carcinogenic effect of chlamydial infection
Effects of water on the stochastic motions of propane confined in MCM-41-S pores
Hydrocarbons confined in porous media find applications in a wide variety of industries and therefore their diffusive behavior is widely studied. Most of the porous media found in natural environments are laden with water, which might affect the confined hydrocarbons. To quantify the effect of hydration, we report here a combined quasielastic neutron scattering (QENS) and molecular dynamics (MD) simulation study on the dynamics of propane confined in the 1.5 nm-wide micropores of MCM-41-S in the presence of water at 230 and 250 K. To eliminate the strong incoherent signal from water and emphasize the propane signal we have used heavy water (D2O). QENS data show two dynamically different populations of propane in MCM-41-S and suggest that the presence of water hinders the diffusion of propane. Weak elastic contributions to the QENS spectra suggest that only long-range translational motion of propane molecules contributes to the quasielastic broadening. MD simulations carried out using a model cylindrical silica pore of 1.6 nm diameter filled with water and propane agree with the experimental finding of water hindering the diffusion of propane. Further, the simulation results suggest that the slowing down of propane motions is a function of the water content within the pore and is stronger at higher water contents. At high water content, the structure and the dynamics, both translational and rotational, of propane are severely impacted. Simulation data suggest that the rotational motion of the propane molecule occurs on time scales much faster than those accessible with the QENS instrument used, and thus explain the weak elastic contribution to the QENS spectra measured in the experiments. This study shows the effects of hydration on the structure and dynamics of volatiles in porous media, which are of interest for fundamental understanding and applied studies of confined fluids
Lifetime measurements in Co and Co
Lifetimes of the and states in Co and the
state in Co were measured using the recoil distance Doppler
shift and the differential decay curve methods. The nuclei were populated by
multi-nucleon transfer reactions in inverse kinematics. Gamma rays were
measured with the EXOGAM Ge array and the recoiling fragments were fully
identified using the large-acceptance VAMOS spectrometer. The E2 transition
probabilities from the and states to the ground
state could be extracted in Co as well as an upper limit for the
(E2) value in Co. The experimental
results were compared to large-scale shell-model calculations in the and
model spaces, allowing to draw conclusions on the single-particle
or collective nature of the various states.Comment: 8 pages, 8 figures, 1 table, accepted for publication in Physical
Review
Keep it SMPL: Automatic Estimation of 3D Human Pose and Shape from a Single Image
We describe the first method to automatically estimate the 3D pose of the
human body as well as its 3D shape from a single unconstrained image. We
estimate a full 3D mesh and show that 2D joints alone carry a surprising amount
of information about body shape. The problem is challenging because of the
complexity of the human body, articulation, occlusion, clothing, lighting, and
the inherent ambiguity in inferring 3D from 2D. To solve this, we first use a
recently published CNN-based method, DeepCut, to predict (bottom-up) the 2D
body joint locations. We then fit (top-down) a recently published statistical
body shape model, called SMPL, to the 2D joints. We do so by minimizing an
objective function that penalizes the error between the projected 3D model
joints and detected 2D joints. Because SMPL captures correlations in human
shape across the population, we are able to robustly fit it to very little
data. We further leverage the 3D model to prevent solutions that cause
interpenetration. We evaluate our method, SMPLify, on the Leeds Sports,
HumanEva, and Human3.6M datasets, showing superior pose accuracy with respect
to the state of the art.Comment: To appear in ECCV 201
Pregnant women with bronchial asthma benefit from progressive muscle relaxation: A randomized, prospective, controlled trial
Background: Asthma is a serious medical problem in pregnancy and is often associated with stress, anger and poor quality of life. The aim of this study was to determine the efficacy of progressive muscle relaxation (PMR) on change in blood pressure, lung parameters, heart rate, anger and health-related quality of life in pregnant women with bronchial asthma. Methods: We treated a sample of 64 pregnant women with bronchial asthma from the local population in an 8-week randomized, prospective, controlled trial. Thirty-two were selected for PMR, and 32 received a placebo intervention. The systolic blood pressure, forced expiratory volume in the first second, peak expiratory flow and heart rate were tested, and the State-Trait Anger Expression Inventory and Health Survey (SF-36) were employed. Results: According to the intend-to-treat principle, a significant reduction in systolic blood pressure and a significant increase in both forced expiratory volume in the first second and peak expiratory flow were observed after PMR. The heart rate showed a significant increase in the coefficient of variation, root mean square of successive differences and high frequency ranges, in addition to a significant reduction in low and middle frequency ranges. A significant reduction on three of five State-Trait Anger Expression Inventory scales, and a significant increase on seven of eight SF-36 scales were observed. Conclusions: PMR appears to be an effective method to improve blood pressure, lung parameters and heart rate, and to decrease anger levels, thus enhancing health-related quality of life in pregnant women with bronchial asthma. Copyright (c) 2006 S. Karger AG, Basel
Rashba precession in quantum wires with interaction
Rashba precession of spins moving along a one-dimensional quantum channel is
calculated, accounting for Coulomb interactions. The Tomonaga--Luttinger model
is formulated in the presence of spin-orbit scattering and solved by
Bosonization. Increasing interaction strength at decreasing carrier density is
found to {\sl enhance} spin precession and the nominal Rashba parameter due to
the decreasing spin velocity compared with the Fermi velocity. This result can
elucidate the observed pronounced changes of the spin splitting on applied gate
voltages which are estimated to influence the interface electric field in
heterostructures only little.Comment: now replaced by published versio
Polymer depletion interaction between two parallel repulsive walls
The depletion interaction between two parallel repulsive walls confining a
dilute solution of long and flexible polymer chains is studied by
field-theoretic methods. Special attention is paid to self-avoidance between
chain monomers relevant for polymers in a good solvent. Our direct approach
avoids the mapping of the actual polymer chains on effective hard or soft
spheres. We compare our results with recent Monte Carlo simulations [A. Milchev
and K. Binder, Eur. Phys. J. B 3, 477 (1998)] and with experimental results for
the depletion interaction between a spherical colloidal particle and a planar
wall in a dilute solution of nonionic polymers [D. Rudhardt, C. Bechinger, and
P. Leiderer, Phys. Rev. Lett. 81, 1330 (1998)].Comment: 17 pages, 3 figures. Final version as publishe
Understanding the UK hospital supply chain in an era of patient choice
Author Posting © Westburn Publishers Ltd, 2011. This is a post-peer-review, pre-copy-edit version of an article which has been published in its definitive form in the Journal of Marketing Management, and has been posted by permission of Westburn Publishers Ltd for personal use, not for redistribution. The article was published in Journal of Marketing Management, 27(3-4), 401 - 423, doi:10.1080/0267257X.2011.547084 http://dx.doi.org/10.1080/0267257X.2011.547084The purpose of this paper is to investigate the UK hospital supply chain in light of recent government policy reform where patients will have, inter alia, greater choice of hospital for elective surgery. Subsequently, the hospital system should become far more competitive with supply chains having to react to these changes as patient demand becomes less predictable. Using a qualitative case study methodology, hospital managers are interviewed on a range of issues. Views on the development of the hospital supply chain in different phases are derived, and are used to develop a map of the current hospital chain. The findings show hospital managers anticipating some significant changes to the hospital supply chain and its workings as Patient Choice expands. The research also maps the various aspects of the hospital supply chain as it moves through different operational phases and highlights underlying challenges and complexities. The hospital supply chain, as discussed and mapped in this research, is original work given there are no examples in the literature that provide holistic representations of hospital activity. At the end, specific recommendations are provided that will be of interest to service to managers, researchers, and policymakers
- âŠ