Age-related changes in blood-brain barrier integrity in C57BL/6J mice

The blood-brain barrier (BBB) is formed by the endothelial cells of the brain microvasculature, which control the molecular traffic between the blood and brain to maintain the neural microenvironment

Stellar black holes: cosmic history and feedback at the dawn of the universe

Significant historic cosmic evolution for the formation rate of stellar black holes is inferred from current theoretical models of the evolution of massive stars, the multiple observations of compact stellar remnants in the near and distant universe, and the cosmic chemical evolution. The mean mass of stellar black holes, the fraction of black holes/neutron stars, and the fraction of black hole high mass X-ray binaries (BH-HMXBs)/solitary black holes increase with redshift. The energetic feedback from large populations of BH-HMXBs form in the first generations of star burst galaxies has been overlooked in most cosmological models of the reionization epoch of the universe. The powerful radiation, jets, and winds from BH-HMXBs heat the intergalactic medium over large volumes of space and keep it ionized until AGN take over. It is concluded that stellar black holes constrained the properties of the faintest galaxies at high redshifts. I present here the theoretical and observational grounds for the historic cosmic evolution of stellar black holes. Detailed calculations on their cosmic impact are presented elsewhere (Mirabel, Dijkstra, Laurent, Loeb, Pritchard, 2011).Comment: 9 pages, 1 color figure. Invited talk at the IAU Symp. 275, Jets at all scales. Held in Buenos Aires on 13-17 September 2010. To be published by Cambridge University Press. Eds. G. Romero, R. Sunyaev and T. Bellon

Recurrent microblazar activity in Cygnus X-1?

Recurrent flaring events at X- and soft gamma-ray energies have been recently reported for the galactic black hole candidate Cygnus X-1. The observed fluxes during these transient outbursts are far higher than what is observed in ``normal'' episodes. Here we suggest that the origin of this radiation is non-thermal and produced by inverse Compton interactions between relativistic electrons in the jet and external photon fields, with a dominant contribution from the companion star field. The recurrent and relatively rapid variability could be explained by the precession of the jet, which results in a variable Doppler amplification.Comment: 4 pages, 5 figures, Accepted for publication in Astronomy & Astrophysics Letter

Low Temperature AC Conductivity in BSCCO (2212)

We report measurements of anamolously large dissipative conductivities in BiSrCaCuO(2212) at low temperatures. We have measured the complex conductivity of BSCCO thin films at 100-600 GHz as a function of doping from the underdoped to the overdoped state. At low temperatures there exists a residual dissipative conductivity which scales with the T=0 superfluid density as the doping is varied. This residual dissipative conductivity is larger than the possible contribution from a thermal population of quasiparticles at the d-wave gap nodes.Comment: Submitted to the Proceedings of the 22nd International Low Temperature Physics Conference. To be published in Physica B (http://www.elsevier.nl/locate/physb); 2 Pages with 2 Figure

The single-electron transport in a three-ion magnetic molecule modulated by a transverse field

We study single-electron transport in a three-ion molecule with strong uniaxial anisotropy and in the presence of a transverse magnetic field. Two magnetic ions are connected to each other through a third, nonmagnetic ion. The magnetic ions are coupled to ideal metallic leads and a back gate voltage is applied to the molecule, forming a field-effect transistor. The microscopic Hamiltonian describing this system includes inter-ion hopping, on-site repulsions, and magnetic anisotropies. For a range of values of the parameters of the Hamiltonian, we obtain an energy spectrum similar to that of single-molecule magnets in the giant-spin approximation where the two states with maximum spin projection along the uniaxial anisotropy axis are well separated from other states. In addition, upon applying an external in-plane magnetic field, the energy gap between the ground and first excited states of the molecule oscillates, going to zero at certain special values of the field, in analogy to the diabolical points resulting from Berry phase interference in the giant spin model. Thus, our microscopic model provides the same phenomenological behavior expected from the giant spin model of a single-molecule magnet but with direct access to the internal structure of the molecule, thus making it more appropriate for realistic electronic transport studies. To illustrate this point, the nonlinear electronic transport in the sequential tunneling regime is evaluated for values of the field near these degeneracy points. We show that the existence of these points has a clear signature in the I-V characteristics of the molecule, most notably the modulation of excitation lines in the differential conductance.Comment: 10 pages, 13 figure

Deep Strong Coupling Regime of the Jaynes-Cummings model

We study the quantum dynamics of a two-level system interacting with a quantized harmonic oscillator in the deep strong coupling regime (DSC) of the Jaynes-Cummings model, that is, when the coupling strength g is comparable or larger than the oscillator frequency w (g/w > 1). In this case, the rotating-wave approximation cannot be applied or treated perturbatively in general. We propose an intuitive and predictive physical frame to describe the DSC regime where photon number wavepackets bounce back and forth along parity chains of the Hilbert space, while producing collapse and revivals of the initial population. We exemplify our physical frame with numerical and analytical considerations in the qubit population, photon statistics, and Wigner phase space.Comment: Published version, note change of title: DSC regime of the JC mode

Circuit Quantum Electrodynamics with a Superconducting Quantum Point Contact

We consider a superconducting quantum point contact in a circuit quantum electrodynamics setup. We study three different configurations, attainable with current technology, where a quantum point contact is coupled galvanically to a coplanar waveguide resonator. Furthermore, we demonstrate that the strong and ultrastrong coupling regimes can be achieved with realistic parameters, allowing the coherent exchange between a superconducting quantum point contact and a quantized intracavity field.Comment: 5 pages, 4 figures. Updated version, accepted for publication as a Rapid Communication in Physical Review