Host genetics and gut microbiome: Perspectives for multiple sclerosis

As a complex disease, Multiple Sclerosis (MS)’s etiology is determined by both genetic and environmental factors. In the last decade, the gut microbiome has emerged as an important environmental factor, but its interaction with host genetics is still unknown. In this review, we focus on these dual aspects of MS pathogenesis: we describe the current knowledge on genetic factors related to MS, based on genome-wide association studies, and then illustrate the interactions between the immune system, gut microbiome and central nervous system in MS, summarizing the evidence available from Experimental Autoimmune Encephalomyelitis mouse models and studies in patients. Finally, as the understanding of influence of host genetics on the gut microbiome composition in MS is in its infancy, we explore this issue based on the evidence currently available from other autoimmune diseases that share with MS the interplay of genetic with environmental factors (Inflammatory Bowel Disease, Rheumatoid Arthritis and Systemic Lupus Erythematosus), and discuss avenues for future research

An improved synthesis of (2E,4Z)-6-(benzyloxy)-4-bromohexa-2,4-dien-1-ol

An improved synthesis of (2E,4Z)-6-(benzyloxy)-4-bromohexa-2,4-dien-1-ol has been devised. This new route increases the throughput and yield of the diene product by circumventing a low yielding preparation of boronic acid intermediate as well as removing the need to use multi-gram quantities of highly toxic thallium salts. In the process of developing this new route, a higher yielding preparation of ( E)-3-hydroxyprop-1-enylboronic acid was also achieved. (c) 2007 Elsevier Ltd. All rights reserved

Valuasi Sumberdaya Air (Studi Kasus Kawasan Mata Air Tataneyan di Kelurahan Kinilow I, Kecamatan Tomohon Utara, Kota Tomohon)

This study aims to determine how how big the valuations of water in the spring Tataneyan located in the Village Kinilow I, District of North Tomohon, Tomohon, by using the concept of economic valuation to calculate the value of the utilization of water resources directly or indirectly. This study was conducted from October to December 2016, using primary and secondary data with sampling technique simple random sampling method and the respondents as many as 30 people. Analysis of the data used is quantitative analysis to identify the value of the value of benefits in the area of water resources in the waters Tataneyan value direct use for domestic households and public bath are also value the presence of fish breeding and agricultural irrigation water spinach. The results showed that the area of the springs Tataneyan have a total economic benefit value of Rp. 1.586.715.372/year. By calculating the average value of the obtained surplus WTP consumers showed the overall consumer receives more benefits than the actual price that is able to pay in exploiting springs Tataneyan. The total value of economic benefits can be used as a reference for local communities in the utilization and management of water in the spring Tataneyan

Relative expression of hypothetical protein-related genes for Bradyrhizobium diazoefficiens CPAC 7.

ABSTRACT: From the proteomic map of Bradyrhizobium diazoefficiens strain CPAC 7 we selected nine hypothetical protein-related genes and evaluated their relative expression by Realtime quantitative PCR (RT-qPCR). The experiment was performed with two treatments (induced or not with 5 µM genistein). Six out of nine protein-related genes were upregulated in the presence genistein

Exhaled breath condensate nitrates, but not nitrites or FENO, relate to asthma control.

SummaryBackgroundAsthma is a chronic respiratory disease, characterised by airways inflammation, obstruction and hyperresponsiveness. Asthma control is the goal of asthma treatment, but many patients have sub-optimal control. Exhaled NO and exhaled breath condensate (EBC) NO metabolites (nitrites and nitrates) measurements are non-invasive tools to assess airways inflammation. Our aim was to investigate the relationships between asthma control and the above-named biomarkers of airways inflammation.MethodsThirty-nine non-smoking asthmatic patients (19 women) aged 50 (21–80) years performed measurements of exhaled NO (FENO), EBC nitrates, nitrites and pH, and answered Asthma Control Questionnaire (ACQ) and Asthma Control Test (ACT)-questionnaire.ResultsThe ACT and ACQ score were strongly interrelated (ρ=−0.84, p<0.001). No relationships between ACT or ACQ score and FENO were found (p>0.05). EBC nitrates were negatively related to ACT score (ρ=−0.34, p=0.03) and positively related to ACQ score (ρ=0.41, p=0.001) while no relation of EBC nitrites to either ACQ or ACT score was found (p>0.05).ConclusionEBC nitrates were the only biomarker that was significantly related to asthma control. This suggests that nitrates, but not nitrites or FENO, reflect an aspect of airways inflammation that is closer related to asthma symptoms. Therefore there is a potential role for EBC nitrates in objective assessment of asthma control

Stochastic perturbations of convex billiards

We consider a strictly convex billiard table with C 2 boundary, with the dynamics subjected to random perturbations. Each time the billiard ball hits the boundary its reflection angle has a random perturbation. The perturbation distribution corresponds to the physical situation where either the scale of the surface irregularities is smaller than but comparable to the diameter of the reflected object, or the billiard ball is not perfectly rigid. We prove that for a large class of such perturbations the resulting Markov chain is uniformly ergodic, although this is not true in general.Fil: Markarian, R.. Universidad de la Republica. Facultad de Ingeniería; UruguayFil: Trivellato Rolla, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigaciones Matemáticas "Luis A. Santalo". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Matemáticas "Luis A. Santalo"; ArgentinaFil: Sidoravicius, V.. Jardim Botânico; BrasilFil: Tal, F. A.. Universidade de Sao Paulo; BrasilFil: Vares, M. E.. Universidade Federal do Rio de Janeiro; Brasi