1,328 research outputs found

    Moral reasoning and homosexuality: the acceptability of arguments about lesbian and gay issues

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    In the political arena, lesbian and gay issues have typically been contested on grounds of human rights, but with variable success. Using a moral developmental framework, the purpose of this study was to explore preferences for different types of moral arguments when thinking about moral dilemmas around lesbian and gay issues. The analysis presented here comprised data collected from 545 students at UK universities, who completed a questionnaire, part of which comprised a moral dilemma task. Findings of the study showed that respondents do not apply moral reasoning consistently, and do not (clearly) favour human rights reasoning when thinking about lesbian and gay issues. Respondents tended to favour reasoning supporting existing social structures and frameworks, therefore this study highlights the importance of structural change in effecting widespread attitude change in relation to lesbian and gay rights issues. The implications of the findings for moral education are also discussed.</p

    Exponential martingales and changes of measure for counting processes

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    We give sufficient criteria for the Dol\'eans-Dade exponential of a stochastic integral with respect to a counting process local martingale to be a true martingale. The criteria are adapted particularly to the case of counting processes and are sufficiently weak to be useful and verifiable, as we illustrate by several examples. In particular, the criteria allow for the construction of for example nonexplosive Hawkes processes as well as counting processes with stochastic intensities depending on diffusion processes

    In-situ velocity imaging of ultracold atoms using slow--light

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    The optical response of a moving medium suitably driven into a slow-light propagation regime strongly depends on its velocity. This effect can be used to devise a novel scheme for imaging ultraslow velocity fields. The scheme turns out to be particularly amenable to study in-situ the dynamics of collective and topological excitations of a trapped Bose-Einstein condensate. We illustrate the advantages of using slow-light imaging specifically for sloshing oscillations and bent vortices in a stirred condensate

    RNA-seq and Tn-seq reveal fitness determinants of vancomycin-resistant Enterococcus faecium during growth in human serum

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    BACKGROUND: The Gram-positive bacterium Enterococcus faecium is a commensal of the human gastrointestinal tract and a frequent cause of bloodstream infections in hospitalized patients. The mechanisms by which E. faecium can survive and grow in blood during an infection have not yet been characterized. Here, we identify genes that contribute to growth of E. faecium in human serum through transcriptome profiling (RNA-seq) and a high-throughput transposon mutant library sequencing approach (Tn-seq). RESULTS: We first sequenced the genome of E. faecium E745, a vancomycin-resistant clinical isolate, using a combination of short- and long read sequencing, revealing a 2,765,010 nt chromosome and 6 plasmids, with sizes ranging between 9.3 kbp and 223.7 kbp. We then compared the transcriptome of E. faecium E745 during exponential growth in rich medium and in human serum by RNA-seq. This analysis revealed that 27.8% of genes on the E. faecium E745 genome were differentially expressed in these two conditions. A gene cluster with a role in purine biosynthesis was among the most upregulated genes in E. faecium E745 upon growth in serum. The E. faecium E745 transposon mutant library was then used to identify genes that were specifically required for growth of E. faecium in serum. Genes involved in de novo nucleotide biosynthesis (including pyrK_2, pyrF, purD, purH) and a gene encoding a phosphotransferase system subunit (manY_2) were thus identified to be contributing to E. faecium growth in human serum. Transposon mutants in pyrK_2, pyrF, purD, purH and manY_2 were isolated from the library and their impaired growth in human serum was confirmed. In addition, the pyrK_2 and manY_2 mutants were tested for their virulence in an intravenous zebrafish infection model and exhibited significantly attenuated virulence compared to E. faecium E745. CONCLUSIONS: Genes involved in carbohydrate metabolism and nucleotide biosynthesis of E. faecium are essential for growth in human serum and contribute to the pathogenesis of this organism. These genes may serve as targets for the development of novel anti-infectives for the treatment of E. faecium bloodstream infections

    Определение оптимальных параметров источника рентгеновского излучения на базе малогабаритного ускорителя электронов

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    Проведено моделирование спектров рентгеновского излучения, генерируемого электронами с энергией 4…10 МэВ в мишенях из различных материалов и разной толщины. Определены оптимальные параметры мишени-конвертора для использования ее в медицинских источниках монохроматического рентгеновского излучения на базе малогабаритных электронных ускорителей. Проведены оценки интенсивности излучения и сравнение источников на базе разных ускорителей

    Temperature and Frequency Dependence of Complex Conductance of Ultrathin YBa2Cu3O7-x Films: A Study of Vortex-Antivortex Pair Unbinding

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    We have studied the temperature dependencies of the complex sheet conductance of 1-3 unit cell (UC) thick YBa2Cu3O7-x films sandwiched between semiconducting Pr0.6Y0.4Ba2Cu3O7-x layers at high frequencies. Experiments have been carried out in a frequency range between: 2 - 30 MHz with one-spiral coil technique, 100 MHz - 1 GHz frequency range with a new technique using the spiral coil cavity and at 30 GHz by aid of a resonant cavity technique. The real and imaginary parts of the mutual-inductance between a coil and a film were measured and converted to complex conductivity by aid of the inversion procedure. We have found a quadratic temperature dependence of the kinetic inductance, L_k^-1(T), at low temperatures independent of frequency, with a break in slope at T^dc_BKT, the maximum of real part of conductance and a large shift of the break temperature and the maximum position to higher temperatures with increasing frequency. We obtain from these data the universal ratio T^dc_BKT/L_k^-1(T^dc_BKT) = 25, 25, and 17 nHK for 1-, 2- and 3UC films, respectively in close agreement with theoretical prediction of 12 nHK for vortex-antivortex unbinding transition. The activated temperature dependence of the vortex diffusion constant was observed and discussed in the framework of vortex-antivortex pair pinning. PACS numbers: 74.80.Dm, 74.25.Nf, 74.72.Bk, 74.76.BzComment: PDF file, 10 pages, 6 figures, to be published in J. Low Temp. Phys.; Proc. of NATO ARW: VORTEX 200

    ASTEC -- the Aarhus STellar Evolution Code

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    The Aarhus code is the result of a long development, starting in 1974, and still ongoing. A novel feature is the integration of the computation of adiabatic oscillations for specified models as part of the code. It offers substantial flexibility in terms of microphysics and has been carefully tested for the computation of solar models. However, considerable development is still required in the treatment of nuclear reactions, diffusion and convective mixing.Comment: Astrophys. Space Sci, in the pres

    First Stars. I. Evolution without mass loss

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    The first generation of stars was formed from primordial gas. Numerical simulations suggest that the first stars were predominantly very massive, with typical masses M > 100 Mo. These stars were responsible for the reionization of the universe, the initial enrichment of the intergalactic medium with heavy elements, and other cosmological consequences. In this work, we study the structure of Zero Age Main Sequence stars for a wide mass and metallicity range and the evolution of 100, 150, 200, 250 and 300 Mo galactic and pregalactic Pop III very massive stars without mass loss, with metallicity Z=10E-6 and 10E-9, respectively. Using a stellar evolution code, a system of 10 equations together with boundary conditions are solved simultaneously. For the change of chemical composition, which determines the evolution of a star, a diffusion treatment for convection and semiconvection is used. A set of 30 nuclear reactions are solved simultaneously with the stellar structure and evolution equations. Several results on the main sequence, and during the hydrogen and helium burning phases, are described. Low metallicity massive stars are hotter and more compact and luminous than their metal enriched counterparts. Due to their high temperatures, pregalactic stars activate sooner the triple alpha reaction self-producing their own heavy elements. Both galactic and pregalactic stars are radiation pressure dominated and evolve below the Eddington luminosity limit with short lifetimes. The physical characteristics of the first stars have an important influence in predictions of the ionizing photon yields from the first luminous objects; also they develop large convective cores with important helium core masses which are important for explosion calculations.Comment: 17 pages, 24 figures, 2 table

    pQCD Physics of multiparton interactions

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    We study production of two pairs of jets in %hard hadron--hadron collisions in view of extracting contribution of {\em double hard interactions} of three and four partons (343\to4, 444\to4). Such interactions, in spite of being power suppressed at the level of the total cross section, become comparable with the standard hard collisions of two partons, 242\to4, in the {\em back-to-back kinematics} when the transverse momentum imbalances of two pairing jets are relatively small. We express differential and total cross sections for two-dijet production in double parton collisions through the generalized two-parton distributions, 2_2GPDs \cite{BDFS1}, that contain large-distance two-parton correlations of non-perturbative origin as well as small-distance correlations due to parton evolution. We find that these large- and small-distance correlations participate in different manner in 4-jet production, and treat them in the leading logarithmic approximation of pQCD that resums collinear logarithms in all orders. A special emphasis is given to 343\to4 double hard interaction processes that occur as an interplay between large- and short-distance parton correlations and were not taken into consideration by approaches inspired by the parton model picture. We demonstrate that the 343\to4 mechanism, being of the same order in \as as the 444\to4 process, turns out to be {\em geometrically enhanced} compared to the latter and should contribute significantly to 4-jet production. The framework developed here takes into systematic consideration perturbative Q2Q^2 evolution of 2_2GPDs. It can be used as a basis for future analysis of NLO corrections to multi-parton interactions (MPI) at LHC and Tevatron colliders, in particular for improving evaluation of QCD backgrounds to new physics searches.Comment: 16 pages,4 figures Improved presentation; list of references reworked; qualitative estimate of the magnitude of different contributions in the beck-to- back region correcte

    Politieke kennis en effecten van nieuws

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    Welk nieuws doet ertoe en hoeveel nieuws doet ertoe, en in welke mate hangt dit af van de politieke kennis van de ontvanger? Dit artikel beschrijft een longitudinale studie naar de verkiezingsstrijd voor het Nederlandse parlement in 2006
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