Temperature equilibration in a fully ionized plasma: electron-ion mass ratio effects

Brown, Preston, and Singleton (BPS) produced an analytic calculation for energy exchange processes for a weakly to moderately coupled plasma: the electron-ion temperature equilibration rate and the charged particle stopping power. These precise calculations are accurate to leading and next-to-leading order in the plasma coupling parameter, and to all orders for two-body quantum scattering within the plasma. Classical molecular dynamics can provide another approach that can be rigorously implemented. It is therefore useful to compare the predictions from these two methods, particularly since the former is theoretically based and the latter numerically. An agreement would provide both confidence in our theoretical machinery and in the reliability of the computer simulations. The comparisons can be made cleanly in the purely classical regime, thereby avoiding the arbitrariness associated with constructing effective potentials to mock up quantum effects. We present here the classical limit of the general result for the temperature equilibration rate presented in BPS. We examine the validity of the m_electron/m_ion --> 0 limit used in BPS to obtain a very simple analytic evaluation of the long-distance, collective effects in the background plasma.Comment: 14 pages, 4 figures, small change in titl

Charged Particle Motion in a Highly Ionized Plasma

A recently introduced method utilizing dimensional continuation is employed to compute the energy loss rate for a non-relativistic particle moving through a highly ionized plasma. No restriction is made on the charge, mass, or speed of this particle. It is, however, assumed that the plasma is not strongly coupled in the sense that the dimensionless plasma coupling parameter g=e^2\kappa_D/ 4\pi T is small, where \kappa_D is the Debye wave number of the plasma. To leading and next-to-leading order in this coupling, dE/dx is of the generic form g^2 \ln[C g^2]. The precise numerical coefficient out in front of the logarithm is well known. We compute the constant C under the logarithm exactly for arbitrary particle speeds. Our exact results differ from approximations given in the literature. The differences are in the range of 20% for cases relevant to inertial confinement fusion experiments. The same method is also employed to compute the rate of momentum loss for a projectile moving in a plasma, and the rate at which two plasmas at different temperatures come into thermal equilibrium. Again these calculations are done precisely to the order given above. The loss rates of energy and momentum uniquely define a Fokker-Planck equation that describes particle motion in the plasma. The coefficients determined in this way are thus well-defined, contain no arbitrary parameters or cutoffs, and are accurate to the order described. This Fokker-Planck equation describes the longitudinal straggling and the transverse diffusion of a beam of particles. It should be emphasized that our work does not involve a model, but rather it is a precisely defined evaluation of the leading terms in a well-defined perturbation theory.Comment: Comments: Published in Phys. Rep. 410/4 (2005) 237; RevTeX, 111 Pages, 17 Figures; Transcription error corrected in temperature equilibration rate (3.61) and (12.44) which replaces \gamma-2 by \gamma-

Characterization of the Active Site and Insight into the Binding Mode of the Anti-angiogenesis Agent Fumagillin to the Manganese(II)-Loaded Methionyl Aminopeptidase from \u3cem\u3eEscherichia coli\u3c/em\u3e

EPR spectra were recorded for methionine aminopeptidase from Escherichia coli (EcMetAP-I) samples (~2.5 mM) to which one and two equivalents of Mn(II) were added (the latter is referred to as [MnMn(EcMetAP-I)]). The spectra for each sample were indistinguishable except that the spectrum of [MnMn(EcMetAP-I)] was twice as intense. The EPR spectrum of [MnMn(EcMetAP-I)] exhibited the characteristic six-line g≈2 EPR signal of mononuclear Mn(II) with A av(55Mn)=9.3 mT (93 G) and exhibited Curie-law temperature dependence. This signal is typical of Mn(II) in a ligand sphere comprising oxygen and/or nitrogen atoms. Other features in the spectrum were observed only as the temperature was raised from that of liquid helium. The temperature dependences of these features are consistent with their assignment to excited state transitions in the S=1, 2 ... 5 non-Kramer’s doublets, due to two antiferromagnetically coupled Mn(II) ions with an S=0 ground state. This assignment is supported by the observation of a characteristic 4.5 mT hyperfine pattern, and by the presence of signals in the parallel mode consistent with a non-Kramers’ spin ladder. Upon the addition of the anti-angiogenesis agent fumagillin to [MnMn(EcMetAP-I)], very small changes were observed in the EPR spectrum. MALDI-TOF mass spectrometry indicated that fumagillin was, however, covalently coordinated to EcMetAP-I. Therefore, the inhibitory action of this anti-angiogenesis agent on EcMetAP-I appears to involve covalent binding to a polypeptide component at or near the active site rather than direct binding to the metal ions

Ridge Production in High-Multiplicity Hadronic Ultra-Peripheral Proton-Proton Collisions

An unexpected result at the RHIC and the LHC is the observation that high-multiplicity hadronic events in heavy-ion and proton-proton collisions are distributed as two "ridges", approximately flat in rapidity and opposite in azimuthal angle. We propose that the origin of these events is due to the inelastic collisions of aligned gluonic flux tubes that underly the color confinement of the quarks in each proton. We predict that high-multiplicity hadronic ridges will also be produced in the high energy photon-photon collisions accessible at the LHC in ultra-peripheral proton-proton collisions or at a high energy electron-positron collider. We also note the orientation of the flux tubes between the quark and antiquark of each high energy photon will be correlated with the plane of the scattered proton or lepton. Thus hadron production and ridge formation can be controlled in a novel way at the LHC by observing the azimuthal correlations of the scattering planes of the ultra-peripheral protons with the orientation of the produced ridges. Photon-photon collisions can thus illuminate the fundamental physics underlying the ridge effect and the physics of color confinement in QCD.Comment: Presented by SJB at Photon 2017: The International Conference on the Structure and the Interactions of the Photon and the International Workshop on Photon-Photon Collisions. CERN, May 22-26, 2017. References adde

Which Way Was I Going? Contextual Retrieval Supports the Disambiguation of Well Learned Overlapping Navigational Routes

Groundbreaking research in animals has demonstrated that the hippocampus contains neurons that distinguish betweenoverlapping navigational trajectories. These hippocampal neurons respond selectively to the context of specific episodes despite interference from overlapping memory representations. The present study used functional magnetic resonanceimaging in humans to examine the role of the hippocampus and related structures when participants need to retrievecontextual information to navigate well learned spatial sequences that share common elements. Participants were trained outside the scanner to navigate through 12 virtual mazes from a ground-level first-person perspective. Six of the 12 mazes shared overlapping components. Overlapping mazes began and ended at distinct locations, but converged in the middle to share some hallways with another maze. Non-overlapping mazes did not share any hallways with any other maze. Successful navigation through the overlapping hallways required the retrieval of contextual information relevant to thecurrent navigational episode. Results revealed greater activation during the successful navigation of the overlapping mazes compared with the non-overlapping mazes in regions typically associated with spatial and episodic memory, including thehippocampus, parahippocampal cortex, and orbitofrontal cortex. When combined with previous research, the current findings suggest that an anatomically integrated system including the hippocampus, parahippocampal cortex, and orbitofrontal cortexis critical for the contextually dependent retrieval of well learned overlapping navigational routes

Processing and Transmission of Information

Contains reports on two research projects.National Aeronautics and Space Administration (Grant NGL 22-009-013)U. S. Army Research Office - Durham (Contract DAHC04-71-C-0039

Novel secondary somatic mutations in Ewing's sarcoma and desmoplastic small round cell tumors.

BackgroundEwing's sarcoma (ES) and desmoplastic small round cell tumors (DSRCT) are small round blue cell tumors driven by an N-terminal containing EWS translocation. Very few somatic mutations have been reported in ES, and none have been identified in DSRCT. The aim of this study is to explore potential actionable mutations in ES and DSRCT.MethodologyTwenty eight patients with ES or DSRCT had tumor tissue available that could be analyzed by one of the following methods: 1) Next-generation exome sequencing platform; 2) Multiplex PCR/Mass Spectroscopy; 3) Polymerase chain reaction (PCR)-based single- gene mutation screening; 4) Sanger sequencing; 5) Morphoproteomics.Principal findingsNovel somatic mutations were identified in four out of 18 patients with advanced ES and two of 10 patients with advanced DSRCT (six out of 28 (21.4%));KRAS (n = 1), PTPRD (n = 1), GRB10 (n = 2), MET (n = 2) and PIK3CA (n = 1). One patient with both PTPRD and GRB10 mutations and one with a GRB10 mutation achieved a complete remission (CR) on an Insulin like growth factor 1 receptor (IGF1R) inhibitor based treatment. One patient, who achieved a partial remission (PR) with IGF1R inhibitor treatment, but later developed resistance, demonstrated a KRAS mutation in the post-treatment resistant tumor, but not in the pre-treatment tumor suggesting that the RAF/RAS/MEK pathway was activated with progression.ConclusionsWe have reported several different mutations in advanced ES and DSRCT that have direct implications for molecularly-directed targeted therapy. Our technology agnostic approach provides an initial mutational roadmap used in the path towards individualized combination therapy