Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores

A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació

Incorporation of nitro-sensitive fluorescent bacteria and nitro-capturing bacteriophages into alginate-cellulose beads as field-deployable biosensor for highly sensitive detection of nitro compounds

Bacterial species capable of expressing fluorophores in response toexternal stimuli are actively being utilized as light-activated sensors forvarious applications. These stimuli-responsive bacteria encapsulatedin miniaturized spherical hydrogels (???microbeads???) are especially useful as a field deployable form of sensors for detecting environmental chemicals, due to the capability of mass production as well as long-range light detection. Herein, genetically engineered bacteria capable of expressing enhanced green fluorescent protein (eGFP+) in response to nitro compounds were encapsulated into alginate-cellulose beads to develop microbead biosensor. Mechanical strength of the conventional alginate microbeads was improved by incorporating anionic cellulose. The encapsulated bacteria proliferated within the microbeads, and eGFP+ expression was proportional to the amount of nitro compounds (e.g. DNT and TNT). Furthermore, the M13 bacteriophage having high binding affinity towards DNT and TNT were also encapsulated into the same microbeads, resulting in increased sensitivity of nitro detection. In addition, the fluorescence emitted from the microbead biosensor deployed on a soil sample was detected at long range (e.g. 20 meters and beyond) using a laser fluorescent scanning system to validate the feasibility as field application and safe long-range detection of explosives

Capecitabine and cisplatin (XP) combination systemic chemotherapy in heavily pre-treated HER2 negative metastatic breast cancer - Fig 1

<p>The median progression free survival (A) and overall survival (B) in total patient population.</p

Capecitabine and cisplatin (XP) combination systemic chemotherapy in heavily pre-treated HER2 negative metastatic breast cancer - Fig 3

<p>Progression free survival according to prior numbers of systemic chemotherapy in total patient population (A) and in hormone receptor positive patients (B).</p

Previous studies of XP regimen in metastatic breast cancer patients previously treated with anthracycline and taxane.

<p>Previous studies of XP regimen in metastatic breast cancer patients previously treated with anthracycline and taxane.</p

Clinical outcomes.

<p>Clinical outcomes.</p