2,439 research outputs found
Skin -To-Skin Contact After Cesarean Delivery.
1. Skin to Skin
Brittany Cerino, BSN, RN, Julia Gogle, MSN, RNC-OB and Roxann Wagner, MSN, RNC-NI
Probing top charged-Higgs production using top polarization at the Large Hadron Collider
We study single top production in association with a charged Higgs in the
type II two Higgs doublet model at the Large Hadron Collider. The polarization
of the top, reflected in the angular distributions of its decay products, can
be a sensitive probe of new physics in its production. We present theoretically
expected polarizations of the top for top charged-Higgs production, which is
significantly different from that in the closely related process of t-W
production in the Standard Model. We then show that an azimuthal symmetry,
constructed from the decay lepton angular distribution in the laboratory frame,
is a sensitive probe of top polarization and can be used to constrain
parameters involved in top charged-Higgs production.Comment: 22 pages, 18 Figures, Discussions about backgrounds and NLO
corrections added, figures modified, references added, Version published in
JHE
Surface electrons at plasma walls
In this chapter we introduce a microscopic modelling of the surplus electrons
on the plasma wall which complements the classical description of the plasma
sheath. First we introduce a model for the electron surface layer to study the
quasistationary electron distribution and the potential at an unbiased plasma
wall. Then we calculate sticking coefficients and desorption times for electron
trapping in the image states. Finally we study how surplus electrons affect
light scattering and how charge signatures offer the possibility of a novel
charge measurement for dust grains.Comment: To appear in Complex Plasmas: Scientific Challenges and Technological
Opportunities, Editors: M. Bonitz, K. Becker, J. Lopez and H. Thomse
Truncated and Helix-Constrained Peptides with High Affinity and Specificity for the cFos Coiled-Coil of AP-1
Protein-based therapeutics feature large interacting surfaces. Protein folding endows structural stability to localised surface epitopes, imparting high affinity and target specificity upon interactions with binding partners. However, short synthetic peptides with sequences corresponding to such protein epitopes are unstructured in water and promiscuously bind to proteins with low affinity and specificity. Here we combine structural stability and target specificity of proteins, with low cost and rapid synthesis of small molecules, towards meeting the significant challenge of binding coiled coil proteins in transcriptional regulation. By iteratively truncating a Jun-based peptide from 37 to 22 residues, strategically incorporating i-->i+4 helix-inducing constraints, and positioning unnatural amino acids, we have produced short, water-stable, alpha-helical peptides that bind cFos. A three-dimensional NMR-derived structure for one peptide (24) confirmed a highly stable alpha-helix which was resistant to proteolytic degradation in serum. These short structured peptides are entropically pre-organized for binding with high affinity and specificity to cFos, a key component of the oncogenic transcriptional regulator Activator Protein-1 (AP-1). They competitively antagonized the cJun–cFos coiled-coil interaction. Truncating a Jun-based peptide from 37 to 22 residues decreased the binding enthalpy for cJun by ~9 kcal/mol, but this was compensated by increased conformational entropy (TDS ≤ 7.5 kcal/mol). This study demonstrates that rational design of short peptides constrained by alpha-helical cyclic pentapeptide modules is able to retain parental high helicity, as well as high affinity and specificity for cFos. These are important steps towards small antagonists of the cJun-cFos interaction that mediates gene transcription in cancer and inflammatory diseases
International Veterinary Epilepsy Task Force recommendations for systematic sampling and processing of brains from epileptic dogs and cats
Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities. For many instances, however, neuropathological studies fail to add substantial data on patients with complete clinical work-up. This may be due to sparse training in epilepsy pathology and or due to lack of neuropathological guidelines for companion animals.
The protocols introduced herein shall facilitate systematic sampling and processing of epileptic brains and therefore increase the efficacy, reliability and reproducibility of morphological studies in animals suffering from seizures.
Brain dissection protocols of two neuropathological centres with research focus in epilepsy have been optimised with regards to their diagnostic yield and accuracy, their practicability and their feasibility concerning clinical research requirements.
The recommended guidelines allow for easy, standardised and ubiquitous collection of brain regions, relevant for seizure generation. Tissues harvested the prescribed way will increase the diagnostic efficacy and provide reliable material for scientific investigations
Sociological and Communication-Theoretical Perspectives on the Commercialization of the Sciences
Both self-organization and organization are important for the further
development of the sciences: the two dynamics condition and enable each other.
Commercial and public considerations can interact and "interpenetrate" in
historical organization; different codes of communication are then
"recombined." However, self-organization in the symbolically generalized codes
of communication can be expected to operate at the global level. The Triple
Helix model allows for both a neo-institutional appreciation in terms of
historical networks of university-industry-government relations and a
neo-evolutionary interpretation in terms of three functions: (i) novelty
production, (i) wealth generation, and (iii) political control. Using this
model, one can appreciate both subdynamics. The mutual information in three
dimensions enables us to measure the trade-off between organization and
self-organization as a possible synergy. The question of optimization between
commercial and public interests in the different sciences can thus be made
empirical.Comment: Science & Education (forthcoming
- …