Alteration and vein mineralisation within the Lizard complex, south Cornwall: Constraints on the timing of serpentinisation.

Two distinct episodes of serpentinisation have been identified within the peridotites of the Lizard complex. The first episode (primary serpentinisation) is represented by the complex and pervasive hydration of the Lizard peridotite. The second (later) episode is characterised by a pale to dark green, pseudo-fibrous mixture of lizardite and chrysotile that is restricted to fractures (vein serpentine). Mineralised north-north-west and east-north-east trending fault zones contain fragments of vein serpentine generated during this second episode. Faults with similar orientations and mineralogy within the gabbro unit contain adularia which have been previously elated by Ar-10-Ar-39 and K-Ar methods at 210-220 Ma (Triassic). Stable isotope ratios indicate that the mineralisation within the gabbro and peridotite is genetically similar. The primary and secondary serpentinisation episodes are therefore interpreted as pre-Triassic in age. A latest Carboniferous to early Permian age is proposed for the formation of vein serpentine and a late Devonian to Carboniferous age is proposed for the primary serpentinisation episode. This is envisaged to have taken place post-obduction but a pre-obduction initiation of serpentinisation cannot be discounted

Baseline geochemistry of Devonian low-grade metasedimentary rocks in Cornwall: preliminary data and environmental significance.

Geochemical baseline data provide information on the state of the environment before modification by mining and other anthropogenic activities. A summary of the analyses of 41 elements on 100 samples from Devonian metasedimentary rocks away from areas of mineralization and granite intrusions in Cornwall are presented. The data show a remarkable consistency. Differences in major elements can be related largely to changes in mineral proportion expected from grain size variations within the sedimentary rocks. The trace element data indicate that similar types of sediment accumulated in the Gramscatho, Looe and Trevone basins and that subsequent metamorphism has not significantly re-distributed elements. Compared with an average UK Lower Palaeozoic shale and the North American Shale Composite, the Devonian metasedimentary rocks of Cornwall appear to be marginally depleted in many trace elements. Values for As, Ni and Cr frequently exceed published soil guideline values, especially in mudstones, which brings into question the issue of the identification of land, which is considered to be polluted

A re-interpretation of the internal structure of the Lizard complex ophiolite, south Cornwall.

publication-status: PublishedPrevious models for the tectonic-stratigraphy of the Lizard complex ophiolite have proposed three thrust-bounded units. However, our studies indicate that post-obduction extensional faulting may have exerted a hitherto unrecognised effect on the present distribution of lithologies. Field and previously published geophysical evidence suggest that the uppermost tectonic unit (the Crousa Downs Unit) represents the downfaulted upper levels of the Goonhilly Downs Unit. Deformed lithologies previously thought to be part of the Goonhilly Downs Unit are reassigned to the underlying Basal Unit. A revised model for the tectonic-stratigraphy is presented. The Basal Nappe is underlain by the Basal Thrust and comprises the Traboe schists, the Landewednack schists and the Old Lizard Head Series. The Goonhilly Downs Nappe, underlain by the Goonhilly Downs Thrust, structurally overlies the Basal Nappe and comprises serpentinised peridotite, Trelan and Crousa Gabbro and the Porthoustock Sheeted Dyke Complex. This work highlights the importance of late- to post-Variscan extensional deformation in south Cornwall

The Geodiversity Profile Handbook

Mineral Industry Research Organisation: Aggregates Sustainability Levy Fun

Access and safety at geological sites: a manual for landowners, quarry operators and the geological visitor

Mineral Industry Research Organisation: Aggregates Sustainability Levy Fun

Assessment of the benefits of user involvement in health research from the Warwick Diabetes Care Research User Group : a qualitative case study

Objective  To assess the benefits of involving health-care users in diabetes research. Design and participants  For this qualitative case study, semi-structured interviews were conducted with researchers who had worked extensively with the group. During regular meetings of the Research User Group, members discussed their views of the group's effectiveness as part of the meeting's agenda. Interviews and discussions were transcribed, coded using N-Vivo software and analysed using constant comparative methods. Results  Involvement of users in research was generally seen as contributing to effective and meaningful research. However, the group should not be considered to be representative of the patient population or participants of future trials. An important contributor to the group's success was its longstanding nature, enabling users to gain more insight into research and form constructive working relationships with researchers. The user-led nature of the group asserted itself, especially, in the language used during group meetings. A partial shift of power from researchers to users was generally acknowledged. Users' main contribution was their practical expertise in living with diabetes, but their involvement also helped researchers to remain connected to the `real world' in which research would be applied. While the group's work fulfilled established principles of consumer involvement in research, important contributions relying on personal interaction between users and researchers were hard to evaluate by process measures alone. Conclusions  We demonstrated the feasibility, acceptability and effectiveness of this longstanding, experienced, lay-led research advisory group. Its impact on research stems from the continuing interaction between researchers and users, and the general ethos of learning from each other in an on-going process. Both process measures and qualitative interviews with stakeholders are needed to evaluate the contributions of service users to health research

Pneumococcal conjugate vaccine dose-ranging studies in humans: A systematic review

Background: Streptococcus pneumoniae is one of the most common bacterial pathogens of infants and young children. Antibody responses against the pneumococcal polysaccharide capsule are the basis of vaccine-mediated protection. We examined the relationship between the dose of polysaccharide in pneumococcal conjugate vaccines (PCVs) and immunogenicity. Methods: A systematic search of English publications that evaluated the immunogenicity of varying doses of pneumococcal conjugate vaccines was performed in Medline and Embase (Ovid Sp) databases in August 2019. We included only articles that involved administration of pneumococcal conjugate vaccine in humans and assessed the immunogenicity of more than one serotype-specific saccharide dose. Results were synthesised descriptively due to the heterogeneity of product valency, product content and vaccine schedule. Results: We identified 1691 articles after de-duplication; 9 studies met our inclusion criteria; 2 in adults, 6 in children and 1 in both. Doses of polysaccharide evaluated ranged from 0.44 mcg to 17.6 mcg. In infants, all doses tested elicited IgG geometric mean concentrations (GMCs) above the established correlate of protection (COP; 0.35 mcg/ml). A month after completion of the administered vaccine schedule, 95% confidence intervals of only three out of all the doses evaluated had GMCs that crossed below the COP. In the adult studies, all adults achieved GMCs that would be considered protective in children who have received 3 standard vaccine doses. Conclusion: For some products, the mean antibody concentrations induced against some pneumococcal serotypes increased with increasing doses of the polysaccharide conjugate, but for other serotypes, there were no clear dose–response relationships or the dose response curves were negative. Fractional doses of polysaccharide which contain less than is included in currently distributed formulations may be useful in the development of higher valency vaccines, or dose-sparing delivery for paediatric use

Mitigating agency risk between investors and ventures’ managers

The general management literature has long focused on the agency risks involved in the relationship between general managers and shareholders. Shareholders can deploy contractual and non-contractual mechanisms to reduce these inefficiencies. This study examines - based on a broad international sample of investment contracts - how the use of contractual and non-contractual mechanisms is related to the degree of risks associated with the venture’s development stage as well as how these practices differ across countries. Hypotheses are tested using a proprietary dataset of 265 hand-collected investment contracts associated with ventures in the U.S., Israel and nine European countries. Findings suggest that the use of mitigating contractual and non-contractual mechanisms is related to the degree of agency risks, and that these practices vary across countries. This study draws implications for how investors can best deploy their capital in different institutional settings whilst nurturing their relationships with managers and entrepreneurs

Recovery after single-breath halothane induction of anaesthesia in daycase patients

A single-breath technique of inhalational induction of anaesthesia allows intravenous induction agents to be avoided. We have investigated recovery from anaesthesia in 40 daycase patients, using tests of psychomotor function. Patients anaesthetised with inhalational induction awaken earlier than those who receive thiopentone, but not significantly earlier. There were no significant differences in postoperative psychomotor function between patients who received thiopentone and those who had inhalational inductions. Single-breath halothane, nitrous-oxide, oxygen induction is an alternative to intravenous induction in cooperative adults, but does not confer significant benefits in terms of recovery.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75757/1/j.1365-2044.1988.tb06685.x.pd