228 research outputs found
Biomass burning related ozone damage on vegetation over the Amazon forest: A model sensitivity study
The HadGEM2 earth system climate model was used to assess the impact of biomass burning on surface ozone concentrations over the Amazon forest and its impact on vegetation, under present-day climate conditions. Here we consider biomass burning emissions from wildfires, deforestation fires, agricultural forest burning, and residential and commercial combustion. Simulated surface ozone concentration is evaluated against observations taken at two sites in the Brazilian Amazon forest for years 2010 to 2012. The model is able to reproduce the observed diurnal cycle of surface ozone mixing ratio at the two sites, but overestimates the magnitude of the monthly averaged hourly measurements by 5-15 ppb for each available month at one of the sites. We vary biomass burning emissions over South America by ±20, 40, 60, 80 and 100% to quantify the modelled impact of biomass burning on surface ozone concentrations and ozone damage on vegetation productivity over the Amazon forest. We used the ozone damage scheme in the "high" sensitivity mode to give an upper limit for this effect. Decreasing South American biomass burning emissions by 100% (i.e. to zero) reduces surface ozone concentrations (by about 15 ppb during the biomass burning season) and suggests a 15% increase in monthly mean net primary productivity averaged over the Amazon forest, with local increases up to 60%. The simulated impact of ozone damage from present-day biomass burning on vegetation productivity is about 230 TgC yr-1. Taking into account that uncertainty in these estimates is substantial, this ozone damage impact over the Amazon forest is of the same order of magnitude as the release of carbon dioxide due to fire in South America; in effect it potentially doubles the impact of biomass burning on the carbon cycle.This work was funded by the Natural Environment
Research Council (NERC) South AMerican Biomass
Burning Analysis (SAMBBA) project grant code NE/J010057/1.
The UK Met Office contribution to this project was funded by
the DECC under the Hadley Centre Climate Programme contract
(GA01101). The Brazilian contribution was funded by Fundacao
de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, projects
08/58100-2 and 12/14437-9). We thank INPA (Instituto Nacional
de Pesquisas da Amazonia) for the coordination work of the LBA
Experiment. We thank USP technicians for the support on data
sampling: Alcides Ribeiro, Ana Lucia Loureiro, Fernando Morais
and Fabio Jorge
Ground-based aerosol characterization during the South American Biomass Burning Analysis (SAMBBA) field experiment
This paper investigates the physical and chemical
characteristics of aerosols at ground level at a site
heavily impacted by biomass burning. The site is located
near Porto Velho, Rondônia, in the southwestern part of the
Brazilian Amazon rainforest, and was selected for the deployment
of a large suite of instruments, among them an
Aerosol Chemical Speciation Monitor. Our measurements
were made during the South American Biomass Burning
Analysis (SAMBBA) field experiment, which consisted of
a combination of aircraft and ground-based measurements
over Brazil, aimed to investigate the impacts of biomass
burning emissions on climate, air quality, and numerical
weather prediction over South America. The campaign took
place during the dry season and the transition to the wet season
in September/October 2012.
During most of the campaign, the site was impacted by
regional biomass burning pollution (average CO mixing ratio
of 0.6 ppm), occasionally superimposed by intense (up
to 2 ppm of CO), freshly emitted biomass burning plumes.
Aerosol number concentrations ranged from ∼ 1000 cm−3
to
peaks of up to 35 000 cm−3
(during biomass burning (BB)
events, corresponding to an average submicron mass mean
concentrations of 13.7 µg m−3
and peak concentrations close
to 100 µg m−3
. Organic aerosol strongly dominated the submicron
non-refractory composition, with an average concentration
of 11.4 µg m−3
. The inorganic species, NH4, SO4,
NO3, and Cl, were observed, on average, at concentrations
of 0.44, 0.34, 0.19, and 0.01 µg m−3
, respectively. Equivalent
black carbon (BCe) ranged from 0.2 to 5.5 µg m−3
,
with an average concentration of 1.3 µg m−3
. During BB
peaks, organics accounted for over 90 % of total mass (submicron
non-refractory plus BCe), among the highest values
described in the literature.
We examined the ageing of biomass burning organic
aerosol (BBOA) using the changes in the H : C and O : C
ratios, and found that throughout most of the aerosol processing
(O : C ∼= 0.25 to O : C ∼= 0.6), no remarkable change
is observed in the H : C ratio (∼ 1.35). Such a result contrasts
strongly with previous observations of chemical ageing
of both urban and Amazonian biogenic aerosols. At higher
levels of processing (O : C > 0.6), the H : C ratio changes
with a H : C/O : C slope of −0.5, possibly due to the development
of a combination of BB (H : C/O : C slope =
0) and biogenic (H : C/O : C slope = −1) organic aerosol
(OA). An analysis of the 1OA/1CO mass ratios yields
very little enhancement in the OA loading with atmospheric
processing, consistent with previous observations. These
results indicate that negligible secondary organic aerosol
(SOA) formation occurs throughout the observed BB plume
Published by Copernicus Publications on behalf of the European Geosciences Union.
12070 J. Brito et al.: Ground-based aerosol characterization during SAMBBA
processing, or that SOA formation is almost entirely balanced
by OA volatilization.
Positive matrix factorization (PMF) of the organic aerosol
spectra resulted in three factors: fresh BBOA, aged BBOA,
and low-volatility oxygenated organic aerosol (LV-OOA).
Analysis of the diurnal patterns and correlation with external
markers indicates that during the first part of the campaign,
OA concentrations are impacted by local fire plumes
with some chemical processing occurring in the near-surface
layer. During the second part of the campaign, long-range
transport of BB plumes above the surface layer, as well as
potential SOAs formed aloft, dominates OA concentrations
at our ground-based sampling site.
This manuscript describes the first ground-based deployment
of the aerosol mass spectrometry at a site heavily impacted
by biomass burning in the Amazon region, allowing
a deeper understanding of aerosol life cycle in this important
ecosystem.This work was supported by the Foundation
for Research Support of the State of São Paulo (FAPESP,
projects 2012/14437-9 and 2013/05014-0), CNPq project 475735-
2012-9, INCT Amazonia, and Natural Environment Research
Council (NERC) project NE/J010073/1. We thank A. Ribeiro,
A. L. Loureiro, F. Morais, F. Jorge, and S. Morais for technical and
logistics support. We thank the National Institute of Meteorology
for providing valuable meteorological data. We gratefully acknowledge
S. Hacon, J. Silva, and W. Bastos for support in the successful
operation of the sampling site
Hypovitaminosis D is associated with negative outcome in dogs with protein losing enteropathy: a retrospective study of 43 cases
Abstract Background Hypovitaminosis D has previously been shown to be prevalent amongst dogs with protein losing enteropathy (PLE). The hypothesis of this study was that Low 25-hydroxyvitamin D (25(OH) D) serum concentrations could be a risk factor for negative outcome in dogs with PLE. Forty-three dogs diagnosed with PLE (2005–2014) and which serum Vitamin D serum concentrations were collected and archived at −80 Degrees C were analyzed. Post-diagnostic communication with referring veterinarians was made to determine outcome of PLE dogss: Dogs which died due to PLE within 4 months after diagnosis (negative outcome group, n = 22) and dogs alive or which died due to another disease at the end point of the study (1 year after diagnosis, good outcome group, n = 21). Serum samples taken at the time of diagnosis were analysed for ionized calcium (iCa) concentrations and serum 25(OH) D concentration. Results Clinical (CCECAI) scores, age at PLE diagnosis, and iCa concentrations were not significantly different between dog groups. A significantly greater (p < 0.001) number of PLE dogs treated with hydrolyzed or elimination diet alone showed good outcome as compared to the PLE negative outcome group. Median serum 25(OH) D concentration was significantly (p = 0.017) lower in dogs with negative outcome versus PLE dogs with good outcome. Using logistic regression analysis, 25(OH) D serum concentration was shown to be a statistically significant factor for outcome determination. Cox regression analysis yielded a hazard ratio of 0.974 (95% CI 0.949, 0.999) per each one nmol/l increase in serum 25(OH) D concentration. Conclusions Low serum 25(OH) D concentration in PLE dogs was significantly associated with poor outcome. Further studies are required to investigate the clinical efficacy of Vitamin D (cholecalciferol) as a potential therapeutic agent for dogs with PLE
Surgery and postoperative radiotherapy a valid treatment for advanced oropharyngeal carcinoma
Since 1992 we have prospectively included all head and neck cancer patients in our health region in a departmental based register. Our hospital takes care of all head and neck cancer patients in our health region consisting of approximately 1 million people. In 1997, we evaluated the results of the treatment of oropharyngeal cancer in the 1992–1997 period. On the basis of this evaluation, we changed our treatment policy for tonsillar and base of tongue carcinoma. We first changed the treatment for the lesions with worst prognosis, i.e., those with T3–T4 carcinomas, from radiotherapy only, to radical surgery and postoperative radiotherapy. We have since that time increasingly also operated the smaller oropharyngeal carcinomas. The 2 years’ overall survival and disease-specific survival for all patients diagnosed in the 1992–1997 period was 56 and 63%, respectively. The results from a similar group of patients in the 6 years’ period from 2000 to 2005, after the change in treatment, have increased to 83 and 88%. When we looked at the subgroup of patients in the 2000–2005 period treated with surgery and postoperative radiotherapy, 45 out of 69 patients (65%) presenting with an oropharyngeal cancer were fit for operation. With radical surgery and postoperative radiation therapy, the 2 years overall survival is now 91%. The 2-year disease-specific survival is 96% and the locoregional control is 98%. This is a marked improvement as compared to radiotherapy alone and definitely competitive with modern radiochemotherapy
Autoimmune and autoinflammatory mechanisms in uveitis
The eye, as currently viewed, is neither immunologically ignorant nor sequestered from the systemic environment. The eye utilises distinct immunoregulatory mechanisms to preserve tissue and cellular function in the face of immune-mediated insult; clinically, inflammation following such an insult is termed uveitis. The intra-ocular inflammation in uveitis may be clinically obvious as a result of infection (e.g. toxoplasma, herpes), but in the main infection, if any, remains covert. We now recognise that healthy tissues including the retina have regulatory mechanisms imparted by control of myeloid cells through receptors (e.g. CD200R) and soluble inhibitory factors (e.g. alpha-MSH), regulation of the blood retinal barrier, and active immune surveillance. Once homoeostasis has been disrupted and inflammation ensues, the mechanisms to regulate inflammation, including T cell apoptosis, generation of Treg cells, and myeloid cell suppression in situ, are less successful. Why inflammation becomes persistent remains unknown, but extrapolating from animal models, possibilities include differential trafficking of T cells from the retina, residency of CD8(+) T cells, and alterations of myeloid cell phenotype and function. Translating lessons learned from animal models to humans has been helped by system biology approaches and informatics, which suggest that diseased animals and people share similar changes in T cell phenotypes and monocyte function to date. Together the data infer a possible cryptic infectious drive in uveitis that unlocks and drives persistent autoimmune responses, or promotes further innate immune responses. Thus there may be many mechanisms in common with those observed in autoinflammatory disorders
Impacts of climate change on plant diseases – opinions and trends
There has been a remarkable scientific output on the topic of how climate change is likely to affect plant diseases in the coming decades. This review addresses the need for review of this burgeoning literature by summarizing opinions of previous reviews and trends in recent studies on the impacts of climate change on plant health. Sudden Oak Death is used as an introductory case study: Californian forests could become even more susceptible to this emerging plant disease, if spring precipitations will be accompanied by warmer temperatures, although climate shifts may also affect the current synchronicity between host cambium activity and pathogen colonization rate. A summary of observed and predicted climate changes, as well as of direct effects of climate change on pathosystems, is provided. Prediction and management of climate change effects on plant health are complicated by indirect effects and the interactions with global change drivers. Uncertainty in models of plant disease development under climate change calls for a diversity of management strategies, from more participatory approaches to interdisciplinary science. Involvement of stakeholders and scientists from outside plant pathology shows the importance of trade-offs, for example in the land-sharing vs. sparing debate. Further research is needed on climate change and plant health in mountain, boreal, Mediterranean and tropical regions, with multiple climate change factors and scenarios (including our responses to it, e.g. the assisted migration of plants), in relation to endophytes, viruses and mycorrhiza, using long-term and large-scale datasets and considering various plant disease control methods
Treatment of HIV-associated facial lipoatrophy: impact on infection progression assessed by viral load and CD4 count
Ultrafast Vibrational Spectroscopy of Aqueous Solution of Methylamine from First Principles MD Simulations
We performed Car-Parrinello molecular dynamics (CPMD) simulations of deuterated aqueous solution of methylamine (MA) to investigate the structure, dynamics and time dependent vibrational spectra of water molecules in the first solvation shell. Our results show that the hydrogen bond of DOD…ND2 is the dominant interaction between ND2 and D2O as compared to the D2O…D2N. The hydrogen bond involving DOD…ND2 has longer lifetime (2.6 ps) than both D2O…D2N (1.1 ps) and water-water hydrogen bonds. The residence time of water molecule inside the first solvation shell of ND2 is 5.72 ps. The vibrational spectral diffusion of water molecules in the first hydration shell of the amine nitrogen of methylamine proceeds with three time scales. A short-time relaxation originates from dynamics of amine-water hydrogen bonds without breaking (90 fs), and a slower relaxation (∼1.8 ps) is due to the breaking of amine-water hydrogen bonds. Another longer time constant (∼7 ps) is due to the escape dynamics of water molecules from the first hydration shell of the amine group
Regulatory Effects of IFN-β on the Development of Experimental Autoimmune Uveoretinitis in B10RIII Mice
BACKGROUND: Experimental autoimmune uveoretinitis (EAU) serves as a model for human intraocular inflammation. IFN-β has been used in the treatment of certain autoimmune diseases. Earlier studies showed that it ameliorated EAU; however, the mechanisms involved in this inhibition are still largely unknown. METHODOLOGY/PRINCIPAL FINDINGS: B10RIII mice were immunized with interphotoreceptor retinoid-binding protein (IRBP) peptide 161-180 in Complete Freund's adjuvant. Splenocytes from different time points after immunization were used to evaluate the expression of IFN-β. An increased expression of IFN-β was observed during EAU and its highest expression was observed on day 16, 3 days after the peak of intraocular inflammation. Splenocytes and draining lymph node cells from mice immunized with IRBP(161-180) on day 13 and control mice were activated with anti-CD3/anti-CD28 antibodies or IRBP(161-180) to evaluate the production of IFN-γ and IL-17. The results showed that IFN-γ and IL-17 were significantly higher in immunized mice as compared to the control mice when exposed to anti-CD3/anti-CD28 antibodies. However, the production of IFN-γ and IL-17 was detected only in immunized mice, but not in the control mice when stimulated with IRBP(161-180). Multiple subcutaneous injections of IFN-β significantly inhibited EAU activity in association with a down-regulated expression of IFN-γ, IL-17 and an enhanced IL-10 production. In an in vitro system using cells from mice, IFN-β suppressed IFN-γ production by CD4(+)CD62L(-) T cells, IL-17 production by CD4(+)CD62L(+/-) T cells and proliferation of CD4(+)CD62L(+/-) T cells. IFN-β inhibited the secretion of IL-6, but promoted the secretion of IL-10 by monocytes. IFN-β-treated monocytes inhibited IL-17 secretion by CD4(+)CD62L(+/-) T cells, but did not influence IFN-γ expression and T cell proliferation. CONCLUSIONS/SIGNIFICANCE: IFN-β may exert its inhibitory effect on EAU by inhibiting Th1, Th17 cells and modulating relevant cytokines. IFN-β may provide a potential treatment for diseases mediated by Th1 and Th17 cells
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