Role of subclinical gut inflammation in the pathogenesis of spondyloarthritis

Subclinical gut inflammation occurring in patients affected by spondyloarthritis (SpA) is correlated with the severity of spine inflammation. Several evidences indicate that dysbiosis occurs in SpA, and that may modulate intestinal permeability and intestinal immune responses. The presence of intestinal dysbiosis is accompanied in SpA patients with the presence of zonulin-dependent alterations of gut-epithelial and gut-vascular barriers. The leakage of epithelial and endothelial surface layers is followed by the translocation of bacterial products, such as lipopolysaccharide and intestinal fatty acid binding protein, in the systemic circulation. These bacterial products may downregulate the expression of CD14 on circulating monocytes leading to an "anergic" phenotype. In the gut, IL-23 may induce the expansion of innate immune cells such as mucosal-associated invariant T cells, γδ T cells, and innate lymphoid cells of group 3 that through the interaction with MAdCAM1 may recirculate form the gut to the sites of SpA active inflammation. On the basis of these findings, gut inflammation observed in SpA patient seems to be not only an epiphenomenon of the on going systemic inflammatory process but may also represent the base camp in which inflammatory cells are activated and from whom they shuttle

Histopathology of the gut in rheumatic diseases

The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity to non-self-antigens. Various evidence indicates that intestinal inflammation occurs in patients with rheumatic diseases. In many rheumatic diseases intestinal inflammation appears to be linked to dysbiosis and possibly represents the common denominator in the pathogenesis of different rheumatic diseases. The continuative interaction between dysbiosis and the intestinal immune system may lead to the aberrant activation of immune cells that can re-circulate from the gut to the sites of extraintestinal inflammation as observed in patients with ankylosing spondylitis. The exact contribution of genetic factors in the development of intestinal inflammation in rheumatic diseases needs to be clarified

Transport properties in correlated systems: An analytical model

Several studies have so far investigated transport properties of strongly correlated systems. Interesting features of these materials are the lack of resistivity saturation well beyond the Mott-Ioffe-Regel limit and the scaling of the resistivity with the hole density in underdoped cuprates. Due to the strongly correlated nature of these materials, mainly numerical techniques have been employed. A key role in this regards is thought to be played by the continuous transfer of spectral weight from coherent to incoherent states. In this paper we employ a simple analytical expression for the electronic Green's function to evaluate both quasi-particle and transport properties in correlated systems. Our analytical approach permits to enlighten the specific role of the spectral transfer due to the correlation on different features. In particular we investigate the dependence of both quasi-particle and transport scattering rate on the correlation degree and the criterion for resistivity saturation. systems.Comment: 11 pages, 8 figures. New version correcting a mistake of the previous version and added figure

Bosonic Seesaw in the Unparticle Physics

Recently, conceptually new physics beyond the Standard Model has been proposed by Georgi, where a new physics sector becomes conformal and provides "unparticle" which couples to the Standard Model sector through higher dimensional operators in low energy effective theory. Among several possibilities, we focus on operators involving the (scalar) unparticle, Higgs and the gauge bosons. Once the Higgs develops the vacuum expectation value (VEV), the conformal symmetry is broken and as a result, the mixing between the unparticle and the Higgs boson emerges. In this paper, we consider a natural realization of bosonic seesaw in the context of unparticle physics. In this framework, the negative mass squared or the electroweak symmetry breaking vacuum is achieved as a result of mass matrix diagonalization. In the diagonalization process, it is important to have zero value in the (1,1)-element of the mass matrix. In fact, the conformal invariance in the hidden sector can actually assure the zero of that element. So, the bosonic seesaw mechanism for the electroweak symmetry breaking can naturally be understood in the framework of unparticle physics.Comment: 5 pages, no figure; added one more referenc

Ammonia observations in the LBV nebula G79.29+0.46. Discovery of a cold ring and some warm spots

The surroundings of Luminous Blue Variable (LBV) stars are excellent laboratories to study the effects of their high UV radiation, powerful winds, and strong ejection events onto the surrounding gas and dust. The LBV G79.29+0.46 powered two concentric infrared rings which may interact with the infrared dark cloud (IRDC) G79.3+0.3. The Effelsberg 100m telescope was used to observe the NH_3 (1,1), (2,2) emission surrounding G79.29+0.46 and the IRDC. In addition, we observed particular positions in the (3,3) transition toward the strongest region of the IRDC. We report here the first coherent shell-like structure of dense NH_3 gas associated with an evolved massive star. The shell, two or three orders of magnitude more tenuous than the IRDC, is well traced in both ammonia lines, and surrounds the ionized nebula. The NH_3 emission in the IRDC is characterized by a low and uniform rotational temperature (T_rot ~ 10 K) and moderately high opacities in the (1,1) line. The rest of the observed field is spotted by warm or hot zones (T_rot > 30 K) and characterized by optically thin emission of the (1,1) line. The NH_3 abundances are about 10^{-8} in the IRDC, and 10^{-10}-10^{-9} elsewhere. The warm temperatures and low abundances of NH_3 in the shell suggest that the gas is being heated and photo-dissociated by the intense UV field of the LBV star. An outstanding region is found to the south-west (SW) of the LBV star within the IRDC. The NH_3 (3,3) emission at the centre of the SW region reveals two velocity components tracing gas at temperatures > 30K. The northern edge of the SW region agrees with the border of the ring nebula and a region of continuum enhancement; here, the opacity of the (1,1) line and the NH_3 abundance do not decrease as expected in a typical clump of an isolated cold dark cloud. This strongly suggests some kind of interaction between the ring nebula and the IRDC.Comment: 15 pages, 13 figures, accepted by A&A. Note the change of title with respect to previous versio

Chaos in temperature in the Sherrington-Kirkpatrick model

We prove the existence of chaos in temperature in the Sherringhton-Kirkpatrick model. The effect is exceedingly small, namely of the ninth order in perturbation theory. The equations describing two systems at different temperatures constrained to have a fixed overlap are studied analytically and numerically, yielding information about the behaviour of the overlap distribution function $P_{T_1,T_2}(q)$ in finite-size systems.Comment: REVTEX, 6 pages, 2 figure

Unique Identification of Lee-Wick Gauge Bosons at Linear Colliders

Grinstein, O'Connell and Wise have recently presented an extension of the Standard Model (SM), based on the ideas of Lee and Wick (LW), which demonstrates an interesting way to remove the quadratically divergent contributions to the Higgs mass induced by radiative corrections. This model predicts the existence of negative-norm copies of the usual SM fields at the TeV scale with ghost-like propagators and negative decay widths, but with otherwise SM-like couplings. In earlier work, it was demonstrated that the LW states in the gauge boson sector of these models, though easy to observe, cannot be uniquely identified as such at the LHC. In this paper, we address the issue of whether or not this problem can be resolved at an $e^+e^-$ collider with a suitable center of mass energy range. We find that measurements of the cross section and the left-right polarization asymmetry associated with Bhabha scattering can lead to a unique identification of the neutral electroweak gauge bosons of the Lee-Wick type.Comment: 16 pages, 6 figures; discussion and references adde

Single WRW_R Production in e−e−e^-e^- Collisions at the NLC

Single $W_R$ production in $e^-e^-$ collisions at the NLC can be used to probe the Majorana nature of the heavy neutrinos present in the Left-Right Symmetric Model below the kinematic threshold for their direct production. For colliders in the $\sqrt {s}=1-1.5$ TeV range, typical cross sections of order $1-10 fb$ are obtained, depending on the specific choice of model parameters. Backgrounds arising from Standard Model processes are shown to be small. This analysis greatly extends the kinematic range of previous studies wherein the production of an on-shell, like-sign pair of $W_R$'s at the NLC was considered.Comment: 13pp, 3 figures (available on request), LaTex, SLAC-PUB-647

A search for water maser emission toward obscured post-AGB star and planetary nebula candidates

Water maser emission at 22 GHz is a useful probe to study the transition between the nearly spherical mass-loss in the AGB to a collimated one in the post-AGB phase. In their turn, collimated jets in the post-AGB phase could determine the shape of planetary nebulae (PNe) once photoionization starts. We intend to find new cases of post-AGB stars and PNe with water maser emission, including water fountains or water-maser-emitting PNe. We observed water maser emission in a sample of 133 objects, with a significant fraction being post-AGB and young PN candidate sources with strong obscuration. We detected this emission in 15 of them, of which seven are reported here for the first time. We identified three water fountain candidates: IRAS 17291-2147, with a total velocity spread of ~96 km/s in its water maser components and two sources (IRAS 17021-3109 and IRAS 17348-2906) that show water maser emission outside the velocity range covered by OH masers. We have also identified IRAS 17393-2727 as a possible new water-maser-emitting PN. The detection rate is higher in obscured objects (14%) than in those with optical counterparts (7%), consistent with previous results. Water maser emission seems to be common in objects that are bipolar in the near-IR (43% detection rate). The water maser spectra of water fountain candidates like IRAS 17291-2147 show significantly less maser components than others (e.g., IRAS 18113-2503). We speculate that most post-AGBs may show water maser emission with wide enough velocity spread (> 100 km/s) when observed with enough sensitivity and/or for long enough periods of time. Therefore, it may be necessary to single out a special group of "water fountains", probably defined by their high maser luminosities. We also suggest that the presence of both water and OH masers in a PN is a better tracer of its youth, rather than the presence of just one of these species.Comment: To be published in Astronomy & Astrophysics. 16 pages, 1 figure (spanning 5 pages). This version includes some minor language corrections and fixes some errors in Table

No light shining through a wall : new results from a photoregeneration experiment

Recently, axion-like particle search has received renewed interest. In particular, several groups have started ``light shining through a wall'' experiments based on magnetic field and laser both continuous, which is very demanding in terms of detector background. We present here the 2$\sigma$ limits obtained so far with our novel set-up consisting of a pulsed magnetic field and a pulsed laser. In particular, we have found that the axion-like particle two photons inverse coupling constant $M$ is $> 8\times 10^5$ GeV provided that the particle mass $m_\mathrm{a} \sim$ 1 meV. Our results definitively invalidate the axion interpretation of the original PVLAS optical measurements with a confidence level greater than 99.9%.Comment: Version that will appear in Physical Review Letters, Vol. 99, n. 18, (2 Nov 2007