Opening the Treasure Chest in Carina

We have mapped the G287.84-0.82 cometary globule (with the Treasure Chest cluster embedded in it) in the South Pillars region of Carina (i) in [CII], 63micron [OI], and CO(11-10) using upGREAT on SOFIA and (ii) in J=2-1 transitions of CO, 13CO, C18O and J=3-2 transitions of H2CO using the APEX telescope in Chile. We probe the morphology, kinematics, and physical conditions of the molecular gas and the photon dominated regions (PDRs) in G287.84-0.82. The [CII] and [OI] emission suggest that the overall structure of the pillar (with red-shifted photo evaporating tails) is consistent with the effect of FUV radiation and winds from eta-Car and O stars in Trumpler 16. The gas in the head of the pillar is strongly influenced by the embedded cluster, whose brightest member is an O9.5V star, CPD-59 2661. The emission of the [CII] and [OI] lines peak at a position close to the embedded star, while all other tracers peak at another position lying to the north-east consistent with gas being compressed by the expanding PDR created by the embedded cluster. The molecular gas inside the globule is probed with the J=2-1 transitions of CO and isotopologues as well as H2CO, and analyzed using a non-LTE model (escape-probability approach), while we use PDR models to derive the physical conditions of the PDR. We identify at least two PDR gas components; the diffuse part (~10^4 cm^-3) is traced by [CII], while the dense (n~ 2-8x10^5 cm^-3) part is traced by [CII], [OI], CO(11-10). Using the F=2-1 transition of [13CII] detected at 50 positions in the region, we derive optical depths (0.9-5), excitation temperatures of [CII] (80-255 K), and N(C+) of 0.3-1x10^19 cm^-2. The total mass of the globule is ~1000 Msun, about half of which is traced by [CII]. The dense PDR gas has a thermal pressure of 10^7-10^8 K cm^-3, which is similar to the values observed in other regions.Comment: Accepted for publication in Astronomy and Astrophysics (abstract slightly abridged

Carney triad. Report of one case

Indexación: Scopus.Carney described a disorder characterized by the presence of several uncommon tumors which were pulmonary chondromas, gastric sarcomas and extra-adrenal paragangliomas. We report a 14 year-old girl in whom multiple gastric tumors were discovered during a study of an iron deficiency anemia and was subjected to a partial gastrectomy. At 25 years of age, she developed several pulmonary chondromas and at 33 years, a mediastinal tumor with features of an extra-adrenal paraganglioma was found. At 35 years of age, a total gastrectomy was performed to remove a gastrointestinal stromal tumor with excision of peritoneal and lymph node metastasis. One year later, the patient died due to liver failure secondary to liver metastases.http://ref.scielo.org/4jhgg

Cosmic-ray acceleration in supernova remnants: non-linear theory revised

A rapidly growing amount of evidences, mostly coming from the recent gamma-ray observations of Galactic supernova remnants (SNRs), is seriously challenging our understanding of how particles are accelerated at fast shocks. The cosmic-ray (CR) spectra required to account for the observed phenomenology are in fact as steep as $E^{-2.2}--E^{-2.4}$, i.e., steeper than the test-particle prediction of first-order Fermi acceleration, and significantly steeper than what expected in a more refined non-linear theory of diffusive shock acceleration. By accounting for the dynamical back-reaction of the non-thermal particles, such a theory in fact predicts that the more efficient the particle acceleration, the flatter the CR spectrum. In this work we put forward a self-consistent scenario in which the account for the magnetic field amplification induced by CR streaming produces the conditions for reversing such a trend, allowing --- at the same time --- for rather steep spectra and CR acceleration efficiencies (about 20%) consistent with the hypothesis that SNRs are the sources of Galactic CRs. In particular, we quantitatively work out the details of instantaneous and cumulative CR spectra during the evolution of a typical SNR, also stressing the implications of the observed levels of magnetization on both the expected maximum energy and the predicted CR acceleration efficiency. The latter naturally turns out to saturate around 10-30%, almost independently of the fraction of particles injected into the acceleration process as long as this fraction is larger than about $10^{-4}$.Comment: 24 pages, 5 figures, accepted for publication in JCA

On the phenomenological classification of continuum radio spectra variability patterns of Fermi blazars

The F-GAMMA program is a coordinated effort to investigate the physics of Active Galactic Nuclei (AGNs) via multi-frequency monitoring of {\em Fermi} blazars. The current study is concerned with the broad-band radio spectra composed of measurement at ten frequencies between 2.64 and 142 GHz. It is shown that any of the 78 sources studied can be classified in terms of their variability characteristics in merely 5 types of variability. The first four types are dominated by spectral evolution and can be reproduced by a simple two-component system made of the quiescent spectrum of a large scale jet populated with a flaring event evolving according to Marscher & Gear (1985). The last type is characterized by an achromatic change of the broad-band spectrum which must be attributed to a completely different mechanism. Here are presented, the classification, the assumed physical system and the results of simulations that have been conducted.Comment: 2011 Fermi Symposium proceedings - eConf C11050

Nonthermal properties of supernova remnant G1.9+0.3

The properties of the - presumably - youngest Galactic supernova remnant (SNR) G1.9+0.3 are investigated within the framework of nonlinear kinetic theory of cosmic ray acceleration in SNRs. The observed angular size and expansion speed as well as the radio and X-ray emission measurements are used to determine relevant physical parameters of this SNR. Under the assumption that SNR G1.9+0.3 is the result of a Type Ia supernova near the Galactic center (at the distance d=8.5 kpc) the nonthermal properties are calculated. In particular, the expected TeV gamma-ray spectral energy density is predicted to be as low as $\epsilon_{\gamma}F_{\gamma} \approx 5\times 10^{-15}$ erg cm$^{-2}$ s$^{-1}$, strongly dependent ($F_{\gamma}\propto d^{-11}$) upon the source distance d.Comment: 7 pages, 5 figures, accepted for publication in Ap

Predicting no-show appointments in a pediatric hospital in Chile using machine learning

The Chilean public health system serves 74% of the country’s population, and 19% of medical appointments are missed on average because of no-shows. The national goal is 15%, which coincides with the average no-show rate reported in the private healthcare system. Our case study, Doctor Luis Calvo Mackenna Hospital, is a public high-complexity pediatric hospital and teaching center in Santiago, Chile. Historically, it has had high no-show rates, up to 29% in certain medical specialties. Using machine learning algorithms to predict no-shows of pediatric patients in terms of demographic, social, and historical variables. To propose and evaluate metrics to assess these models, accounting for the cost-effective impact of possible intervention strategies to reduce no-shows. We analyze the relationship between a no-show and demographic, social, and historical variables, between 2015 and 2018, through the following traditional machine learning algorithms: Random Forest, Logistic Regression, Support Vector Machines, AdaBoost and algorithms to alleviate the problem of class imbalance, such as RUS Boost, Balanced Random Forest, Balanced Bagging and Easy Ensemble. These class imbalances arise from the relatively low number of no-shows to the total number of appointments. Instead of the default thresholds used by each method, we computed alternative ones via the minimization of a weighted average of type I and II errors based on cost-effectiveness criteria. 20.4% of the 395,963 appointments considered presented no-shows, with ophthalmology showing the highest rate among specialties at 29.1%. Patients in the most deprived socioeconomic group according to their insurance type and commune of residence and those in their second infancy had the highest no-show rate. The history of non-attendance is strongly related to future no-shows. An 8-week experimental design measured a decrease in no-shows of 10.3 percentage points when using our reminder strategy compared to a control group. Among the variables analyzed, those related to patients’ historical behavior, the reservation delay from the creation of the appointment, and variables that can be associated with the most disadvantaged socioeconomic group, are the most relevant to predict a no-show. Moreover, the introduction of new cost-effective metrics significantly impacts the validity of our prediction models. Using a prototype to call patients with the highest risk of no-shows resulted in a noticeable decrease in the overall no-show rate.</p

EFECTO DE EXTRACTOS ACUOSOS DEPhyllanthus sellowianusSOBRE LASPROPIEDADES VISCOELÁSTICAS DE GLÓBULOS ROJOS HUMANOS: ACTIVIDAD ANTIDIABÉTICA IN VITRO

Phyllanthus sellowianusMüll (Klotzch) Arg. is a native plant used for diabetes treatment. It is currently of interest to evaluate its activity on the mechanical properties of human red blood cells to elucidate its mechanism of action as an antidiabetic. For this, aqueous extracts were prepared by various extractive techniques. Using the Erythrocyte Rheometer, the in vitroeffect on the viscoelastic parameters of glycated human red blood cells, as occurs by hyperglycemiain diabetes, was evaluated. The results obtained from the treatment with the extracts show that they affect erythrocyte viscoelasticity and can reverse the glycation effects

The costs of preventing and treating chagas disease in Colombia

Background: The objective of this study is to report the costs of Chagas disease in Colombia, in terms of vector disease control programmes and the costs of providing care to chronic Chagas disease patients with cardiomyopathy. Methods: Data were collected from Colombia in 2004. A retrospective review of costs for vector control programmes carried out in rural areas included 3,084 houses surveyed for infestation with triatomine bugs and 3,305 houses sprayed with insecticide. A total of 63 patient records from 3 different hospitals were selected for a retrospective review of resource use. Consensus methodology with local experts was used to estimate care seeking behaviour and to complement observed data on utilisation. Findings: The mean cost per house per entomological survey was $4.4 (in US$ of 2004), whereas the mean cost of spraying a house with insecticide was $27. The main cost driver of spraying was the price of the insecticide, which varied greatly. Treatment of a chronic Chagas disease patient costs between$46.4 and $7,981 per year in Colombia, depending on severity and the level of care used. Combining cost and utilisation estimates the expected cost of treatment per patient-year is$1,028, whereas lifetime costs averaged $11,619 per patient. Chronic Chagas disease patients have limited access to healthcare, with an estimated 22% of patients never seeking care. Conclusion: Chagas disease is a preventable condition that affects mostly poor populations living in rural areas. The mean costs of surveying houses for infestation and spraying infested houses were low in comparison to other studies and in line with treatment costs. Care seeking behaviour and the type of insurance affiliation seem to play a role in the facilities and type of care that patients use, thus raising concerns about equitable access to care. Preventing Chagas disease in Colombia would be cost-effective and could contribute to prevent inequalities in health and healthcare.Wellcome Trus