9,310 research outputs found
Euthanasia and physician-assisted suicide for patients with depression. Thought-provoking remarks
Euthanasia and medical assistance in dying entail daunting ethical and moral challenges, in addition to a host of medical and clinical issues, which are further complicated in cases of patients whose decision-making skills have been negatively affected or even impaired by psychiatric disorders. The authors closely focus on clinical depression and relevant European laws that have over the years set firm standards in such a complex field. Pertaining to the mental health realm specifically, patients are required to undergo a mental competence assessment in order to request aid in dying. The way psychiatrists deal and interact with decisionally capable patients who have decided to end their own lives, on account of sufferings which they find to be unbearable, may be influenced by subjective elements such as ethical and cultural biases on the part of the doctors involved. Moreover, critics of medical aid in dying claim that acceptance of such practices might gradually lead to the acceptance or practice of involuntary euthanasia for those deemed to be nothing more than a burden to society, a concept currently unacceptable to the vast majority of observers. Ultimately, the authors conclude, the key role of clinicians should be to provide alternatives to those who feel so hopeless as to request assistance in dying, through palliative care and effective social and health care policies for the weakest among patients: lonely, depressed or ill-advised people
Effect of Martian Suspended Dust on Albedo Measurements from the MGS-TES Data
Suspended dust on Mars influences albedo measurements by orbiting instruments, but not necessary the real surface albedo. The aim of this study is to characterize the role of suspended aerosols on albedo measurement by remote sensing instruments
A nonmonotone GRASP
A greedy randomized adaptive search procedure (GRASP) is an itera-
tive multistart metaheuristic for difficult combinatorial optimization problems. Each
GRASP iteration consists of two phases: a construction phase, in which a feasible
solution is produced, and a local search phase, in which a local optimum in the
neighborhood of the constructed solution is sought. Repeated applications of the con-
struction procedure yields different starting solutions for the local search and the
best overall solution is kept as the result. The GRASP local search applies iterative
improvement until a locally optimal solution is found. During this phase, starting from
the current solution an improving neighbor solution is accepted and considered as the
new current solution. In this paper, we propose a variant of the GRASP framework that
uses a new ânonmonotoneâ strategy to explore the neighborhood of the current solu-
tion. We formally state the convergence of the nonmonotone local search to a locally
optimal solution and illustrate the effectiveness of the resulting Nonmonotone GRASP
on three classical hard combinatorial optimization problems: the maximum cut prob-
lem (MAX-CUT), the weighted maximum satisfiability problem (MAX-SAT), and
the quadratic assignment problem (QAP)
Hybridization of multi-objective deterministic particle swarm with derivative-free local searches
The paper presents a multi-objective derivative-free and deterministic global/local hybrid algorithm for the efficient and effective solution of simulation-based design optimization (SBDO) problems. The objective is to show how the hybridization of two multi-objective derivative-free global and local algorithms achieves better performance than the separate use of the two algorithms in solving specific SBDO problems for hull-form design. The proposed method belongs to the class of memetic algorithms, where the global exploration capability of multi-objective deterministic particle swarm optimization is enriched by exploiting the local search accuracy of a derivative-free multi-objective line-search method. To the authors best knowledge, studies are still limited on memetic, multi-objective, deterministic, derivative-free, and evolutionary algorithms for an effective and efficient solution of SBDO for hull-form design. The proposed formulation manages global and local searches based on the hypervolume metric. The hybridization scheme uses two parameters to control the local search activation and the number of function calls used by the local algorithm. The most promising values of these parameters were identified using forty analytical tests representative of the SBDO problem of interest. The resulting hybrid algorithm was finally applied to two SBDO problems for hull-form design. For both analytical tests and SBDO problems, the hybrid method achieves better performance than its global and local counterparts
Self-T-Dual Brane Cosmology and the Cosmological Constant Problem
We consider a codimension-one brane embedded in a gravity-dilaton bulk
action, whose symmetries are compatible with T-duality along the space-like
directions parallel to the brane, and the bulk time-like direction. The
equations of motions in the string frame allow for a smooth background obtained
by the union of two symmetric patches of AdS space. The Poincar\'{e} invariance
of the solution appears to hold independently of the value of the brane vacuum
energy, through a self-tuning property of the dilaton ground state. Moreover,
the effective cosmology displays a bounce, at which the scale factor does not
shrink to zero. Finally, by exploiting the T-duality symmetry, we show how to
construct an ever-expanding Universe, along the lines of the Pre-Big Bang
scenario.Comment: Minor corrections, comments & references added. Accepted for
publicatio
The effect of pre-curing UV-irradiation on the crosslinking of silicone rubber
A recent work made use of selective pre-curing UV-irradiation and its effect on the kinetics of reaction of heat-cure silicone elastomers to spatially tune its viscoelastic properties and design architected solid membranes. The present study adds to the possibility of controlling the local properties of spatially graded materials by exploring the effect of key processing parameters such as the UV dose and the silicone mix thickness on the vulcanization kinetics. Dynamic Differential Scanning Calorimetry measurements have been performed showing that, over the conditions explored, the higher the UV dose, the slower the kinetics reaction. Additionally, complete crosslinking was always reached. Companion modeling effort using the Kissinger reaction model is attempted and the effects of processing parameters on the apparent activation energy are discussed. This work is a crucial first step towards the control of the processing settings needed to design architected silicone rubber membranes with spatially controlled mechanical property gradients obtained from a unique macromolecular network
An algorithmic approach to the existence of ideal objects in commutative algebra
The existence of ideal objects, such as maximal ideals in nonzero rings,
plays a crucial role in commutative algebra. These are typically justified
using Zorn's lemma, and thus pose a challenge from a computational point of
view. Giving a constructive meaning to ideal objects is a problem which dates
back to Hilbert's program, and today is still a central theme in the area of
dynamical algebra, which focuses on the elimination of ideal objects via
syntactic methods. In this paper, we take an alternative approach based on
Kreisel's no counterexample interpretation and sequential algorithms. We first
give a computational interpretation to an abstract maximality principle in the
countable setting via an intuitive, state based algorithm. We then carry out a
concrete case study, in which we give an algorithmic account of the result that
in any commutative ring, the intersection of all prime ideals is contained in
its nilradical
Additive energy forward curves in a Heath-Jarrow-Morton framework
One of the peculiarities of power and gas markets is the delivery mechanism
of forward contracts. The seller of a futures contract commits to deliver, say,
power, over a certain period, while the classical forward is a financial
agreement settled on a maturity date. Our purpose is to design a
Heath-Jarrow-Morton framework for an additive, mean-reverting, multicommodity
market consisting of forward contracts of any delivery period. The main
assumption is that forward prices can be represented as affine functions of a
universal source of randomness. This allows us to completely characterize the
models which prevent arbitrage opportunities: this boils down to finding a
density between a risk-neutral measure , such that the prices of
traded assets like forward contracts are true -martingales, and the
real world probability measure , under which forward prices are
mean-reverting. The Girsanov kernel for such a transformation turns out to be
stochastic and unbounded in the diffusion part, while in the jump part the
Girsanov kernel must be deterministic and bounded: thus, in this respect, we
prove two results on the martingale property of stochastic exponentials. The
first allows to validate measure changes made of two components: an
Esscher-type density and a Girsanov transform with stochastic and unbounded
kernel. The second uses a different approach and works for the case of
continuous density. We apply this framework to two models: a generalized
Lucia-Schwartz model and a cross-commodity cointegrated market.Comment: 28 page
The Human SLC25A33 and SLC25A36 Genes of Solute Carrier Family 25 Encode Two Mitochondrial Pyrimidine Nucleotide Transporters
The human genome encodes 53 members of the solute carrier family 25 (SLC25), also called the mitochondrial carrier family, many of which have been shown to transport inorganic anions, amino acids, carboxylates, nucleotides, and coenzymes across the inner mitochondrial membrane, thereby connecting cytosolic and matrix functions. Here two members of this family, SLC25A33 and SLC25A36, have been thoroughly characterized biochemically. These proteins were overexpressed in bacteria and reconstituted in phospholipid vesicles. Their transport properties and kinetic parameters demonstrate that SLC25A33 transports uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism and SLC25A36 cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport. Both carriers also transported guanine but not adenine (deoxy)nucleotides. Transport catalyzed by both carriers was saturable and inhibited by mercurial compounds and other inhibitors of mitochondrial carriers to various degrees. In confirmation of their identity (i) SLC25A33 and SLC25A36 were found to be targeted to mitochondria and (ii) the phenotypes of Saccharomyces cerevisiae cells lacking RIM2, the gene encoding the well characterized yeast mitochondrial pyrimidine nucleotide carrier, were overcome by expressing SLC25A33 or SLC25A36 in these cells. The main physiological role of SLC25A33 and SLC25A36 is to import/export pyrimidine nucleotides into and from mitochondria, i.e. to accomplish transport steps essential for mitochondrial DNA and RNA synthesis and breakdown
Cytometric analysis, genetic manipulation and antibiotic selection of the snail embryonic cell line Bge from Biomphalaria glabrata, the intermediate host of Schistosoma mansoni.
The invertebrate cell line, Bge, from embryos of the snail Biomphalaria glabrata, remains to date the only established cell line from any species of the Phylum Mollusca. Since its establishment in 1976 by Eder Hansen, few studies have focused on profiling its cytometrics, growth characteristics or sensitivity to xenobiotics. Bge cells are reputed to be challenging to propagate and maintain. Therefore, even though this cell line is a noteworthy resource, it has not been studied widely. With growing interest in functional genomics, including genetic transformation, to elucidate molecular aspects of the snail intermediate hosts responsible for transmission of schistosomiasis, and aiming to enhance the convenience of maintenance of this molluscan cell line, we deployed the xCELLigene real time approach to study Bge cells. Doubling times for three isolates of Bge, termed CB, SL and UK, were longer than for mammalian cell lines - longer than 40 h in complete Bge medium supplemented with 7% fetal bovine serum at 25 °C, ranging from âŒ42 h to âŒ157 h when 40,000 cells were seeded. To assess the potential of the cells for genetic transformation, antibiotic selection was explored. Bge cells were sensitive to the aminonucleoside antibiotic puromycin (from Streptomyces alboniger) from 5 ÎŒg/ml to 200 ng/ml, displaying a half maximal inhibitory concentration (IC50) of âŒ1.91 ÎŒg/ml. Sensitivity to puromycin, and a relatively quick kill time (<48 h in 5 ÎŒg/ml) facilitated use of this antibiotic, together with the cognate resistance gene (puromycin N-acetyl-transferase) for selection of Bge cells transformed with the PAC gene (puroR). Bge cells transfected with a plasmid encoding puroR were partially rescued when cultured in the presence of 5 ÎŒg/ml of puromycin. These findings pave the way for the development of functional genomic tools applied to the host-parasite interaction during schistosomiasis and neglected tropical trematodiases at large
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