JRC Ispra site Environmental Footprint (OEF): Application of the Commission Recommendation 2013/179/EU and of the OEFSR Guidance v.6.3- Reporting year 2015 -

This report represents the summary of a work carried out over the last few years involving different Units of the Joint Research Centre and a team of external consultants and reviewers. The OEF method (Organisation Environmental Footprint), together with the PEF method (Product Environmental Footprint), was developed by the JRC Life Cycle Assessment (LCA) Team (now in the Land Resources Unit, D3). Both methods were published in annex to the Commission Recommendation 2013/179/EU of 9 April 2013 on the use of common methods to measure and communicate the life cycle environmental performance of products and organisations. The JRC Ispra is the 3rd largest site of the European Commission. The site is a combination of scientific activities and a broad set of supporting operations, ranging from power generation to water supply and wastewater treatment up to nuclear decommissioning. The site applies EMAS (the EU Environmental Management and Audit Scheme) to continuously improve its environmental performance and communicate it to the public. The application of the OEF, started in 2012 and reiterated over time, was a natural process and turned out to be quite beneficial for both tools. EMAS, in fact, has been getting complementary life cycle based information from the OEF while the latter has been gaining hands-on experience from EMAS in view of testing and possibly improving its methodological foundations. The JRC is therefore a unique field of play, a sort of “living-lab” where research and administration cooperate in a “win-win” perspective. This third version of the OEF study was submitted to an external review panel of distinguished experts in the domain of environmental footprinting. We are happy to present the report to the external public and hope to encourage other organisations to follow our path towards sustainability.JRC.D.3-Land Resource

Glomerular filtration rate: A prognostic marker in atrial fibrillation-A subanalysis of the AntiThrombotic Agents Atrial Fibrillation.

OBJECTIVE An increased cardiovascular mortality and morbidity has been widely reported in patients with atrial fibrillation (AF). In this study, a subanalysis of the AntiThrombotic Agents Atrial Fibrillation (ATA-AF) is performed with the aim to evaluate estimated glomerular filtration rate (eGFR) as an independent prognostic marker of cardiovascular mortality and morbidity in patients with AF. METHODS AND RESULTS The ATA-AF study enrolled 7148 patients with AF, in 360 Italian centers. The eGFR was calculated from data reported in patient notes or hospital database. This post-hoc analysis included 1097 AF patients with eGFR data available and 1-year clinical follow-up. The endpoint was assessed as cardiovascular mortality and/or hospital admission for cardiovascular causes at follow-up. Patients were also divided in two groups according to the eGFR (<60 and ≥60 mL/min/1.73 m ). The Kaplan-Meyer curve for the mentioned endpoint showed a higher endpoint incidence in the group of patient with eGFR below 60 mL/min/1.73 m (P < 0.001). Using multivariate analysis (Cox regression), a trend toward a higher rate of occurrence of the primary endpoint was observed for eGFR below 60 mL/min/1.73 m without reaching the conventional level of statistical significance (hazard ratio [HR] 1.40; 95% confidence interval [CI] 0.99-1.99; P = 0.0572). When eGFR was included in the analysis as continuous variable a significant correlation was observed with the combined endpoint at the Cox regression (HR 0.99, 95% CI 0.98-0.99, P = 0.04). CONCLUSION The result of this post-hoc analysis indicates that an impaired eGFR is independently associated with worse prognosis among patients with AF