74 research outputs found
A New Biophysical Metric for Interrogating the Information Content in Human Genome Sequence Variation: Proof of Concept
Various studies have shown an association between single nucleotide
polymorphisms (SNPs) and common disease. We hypothesize that information
encoded in the structure of SNP haploblock variation illumines molecular
pathways and cellular mechanisms involved in the regulation of host adaptation
to the environment. We developed and utilized the normalized information
content (NIC), a novel metric based on SNP haploblock variation. We found that
all SNP haploblocks with statistically low information content contained
putative transcription factor binding sites and microRNA motifs. We were able
to translate a biophysical, mathematical measure of common variants into a
deeper understanding of the life sciences through analysis of biochemical
patterns associated with SNP haploblock variation. We submit that this new
metric, NIC, may be useful in decoding the functional significance of common
variation in the human genome and in analyzing the regulation of molecular
pathways involved in host adaptation to environmental pathogens.Comment: 13 page
The effects of improved auditory feedback on the verbalizations of an autistic child
Allowing autistic children to control the volume and direction of their auditory inputs apparently affects their language behavior. Further studies are needed, however, to determine the extent that use of devices such as the Phonic Ear will be of value in increasing vocalizations in these children.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44598/1/10803_2005_Article_BF01531619.pd
Structural versus Electrical Functionalization of Oligo(phenyleneethynylene) Diamine Molecular Junctions
We explore both experimentally and theoretically the conductance and packing of molecular junctions based on oligo(phenyleneethynylene) (OPE) diamine wires, when a series of functional groups are incorporated into the wires. Using the scanning tunnelling microscopy break-junction (STM BJ) technique, we study these compounds in two environments (air and 1,2,4-trichlorobenzene) and explore different starting molecular concentrations. We show that the electrical conductance of the molecular junctions exhibits variations among different compounds, which are significant at standard concentrations but become unimportant when working at a low enough concentration. This shows that the main effect of the functional groups is to affect the packing of the molecular wires, rather than to modify their electrical properties. Our theoretical calculations consistently predict no significant changes in the conductance of the wires due to the electronic structure of the functional groups, although their ability to hinder ring rotations within the OPE backbone can lead to higher conductances at higher packing densities
Characterizing the Intramolecular H-bond and Secondary Structure in Methylated GlyGlyH+ with H2 Predissociation Spectroscopy
Condicionantes de consolidação de redes de cooperação interorganizacional: um estudo de caso sobre o Rio Grande do Sul
Electronically developed theory and procedure for distribution channel management via electronic data interchange linkage
Learning as we go: the US army adapts to counterinsurgency in Iraq, July 2004–December 2006
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