Isabelle/SACM: Computer-Assisted Assurance Cases with Integrated Formal Methods

Assurance cases (ACs) are often required to certify critical systems. The use of integrated formal methods (FMs) in assurance can improve automation, increase confidence, and overcome errant reasoning. However, ACs can rarely be fully formalised, as the use of FMs is contingent on models that are validated by informal processes. Consequently, assurance techniques should support both formal and informal artifacts, with explicated inferential links between them. In this paper, we contribute a formal machine-checked interactive language for the computer-assisted construction of ACs called Isabelle/SACM. The framework guarantees well-formedness, consistency, and traceability of ACs, and allows a tight integration of formal and informal evidence of various provenance. To validate Isabelle/SACM, we present a novel formalisation of the Tokeneer benchmark, verify its security requirements, and form a mechanised AC that combines the resulting formal and informal artifacts

ICAR: endoscopic skull‐base surgery

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Consensus Nomenclature for Reporting Neovascular Age-Related Macular Degeneration Data Consensus on Neovascular Age-Related Macular Degeneration Nomenclature Study Group

PURPOSE: To establish a process to evaluate and standardize a state-of-the-art nomenclature for reporting neovascular age-related macular degeneration (AMD) data. DESIGN: Consensus meeting. PARTICIPANTS: An international panel of retina specialists, imaging and image reading center experts, and ocular pathologists. METHODS: During several meetings organized under the auspices of the Macula Society, an international study group discussed and codified a set nomenclature framework for classifying the subtypes of neovascular AMD and associated lesion components. MAIN OUTCOME MEASURES: A consensus classification of neovascular AMD. RESULTS: The study group created a standardized working definition of AMD. The components of neovascular AMD were defined and subclassified. Disease consequences of macular neovascularization were delineated. CONCLUSIONS: The framework of a consensus nomenclature system, a definition of AMD, and a delineation of the subtypes of neovascular AMD were developed. Establishing a uniform set of definitions will facilitate comparison of diverse patient groups and different studies. The framework presented is modified and updated readily, processes that are anticipated to occur on a periodic basis. The study group suggests that the consensus standards outlined in this article be used in future reported studies of neovascular AMD and clinical practice