Experiments on the stability and transition of two-dimensional and three-dimensional boundary layers with suction

The preliminary experimental development work directed towards the understanding of transition in boundary layers with suction is presented. The basic stability experiment was established and the facility was certified

Iron fluorescence from within the innermost stable orbit of black hole accretion disks

The fluorescent iron Ka line is a powerful observational probe of the inner regions of black holes accretion disks. Previous studies have assumed that only material outside the radius of marginal stability can contribute to the observed line emission. Here, we show that fluorescence by material inside the radius of marginal stability, which is in the process of spiralling towards the event horizon, can have a observable influence on the iron line profile and equivalent width. For concreteness, we consider the case of a geometrically thin accretion disk, around a Schwarzschild black hole, in which fluorescence is excited by an X-ray source placed at some height above the disk and on the axis of the disk. Fully relativistic line profiles are presented for various source heights and efficiencies. It is found that the extra line flux generally emerges in the extreme red wing of the iron line, due to the large gravitational redshift experienced by photons from the region within the radius of marginal stability. We apply our models to the variable iron line seen in the ASCA spectrum of the Seyfert nucleus MCG-6-30-15. It is found that the change in the line profile, equivalent width, and continuum normalization, can be well explained as being due to a change in the height of the source above the disk. We discuss the implications of these results for distinguishing rapidly-rotating black holes from slowly rotating holes using iron line diagnostics.Comment: 20 pages, LaTeX. Accepted for publication in Astrophysical Journal. Figures 3 to 7 replaced with corrected versions (previous figures affected by calculational error). Some changes in the best fitting parameter

Automated reduction of instantaneous flow field images

An automated data reduction system for the analysis of interference fringe patterns obtained using the particle image velocimetry technique is described. This system is based on digital image processing techniques that have provided the flexibility and speed needed to obtain more complete automation of the data reduction process. As approached here, this process includes scanning/searching for data on the photographic record, recognition of fringe patterns of sufficient quality, and, finally, analysis of these fringes to determine a local measure of the velocity magnitude and direction. The fringe analysis as well as the fringe image recognition are based on full frame autocorrelation techniques using parallel processing capabilities

Are the Nuclei of Seyfert 2 Galaxies Viewed Face-On?

We show from modeling the Fe Kalpha line in the ASCA spectra of four X-ray bright narrow emission line galaxies (Seyfert types 1.9 and 2) that two equally viable physical models can describe the observed line profile. The first is discussed by Turner et al. (1998) and consists of emission from a nearly pole-on accretion disk. The second, which is statistically preferred, is a superposition of emission from an accretion disk viewed at an intermediate inclination of about 48 degrees and a distinct, unresolved feature that presumably originates some distance from the galaxy nucleus. The intermediate inclination is entirely consistent with unified schemes and our findings challenge recent assertions that Seyfert 2 galaxies are preferentially viewed with their inner regions face-on. We derive mean equivalent widths for the narrow and disk lines of =60 eV and = 213 eV, respectively. The X-ray data are well described by a geometry in which our view of the active nucleus intersects and is blocked by the outer edges of the obscuring torus, and therefore do not require severe misalignments between the accretion disk and the torus.Comment: 19 pages, 3 postscript figures. Accepted for publication in ApJ

Response of Riesling vines to training system and pruning strategy

Riesling vines were subjected over a 3-year old period to four training systems ('flachbogen'; 'pendelbogen'; low cordon; Moselle loop) in combination with two pruning strategies (30 + 10 balanced pruning; 25 nodes/m of row). Low cordon-trained vines yielded highest and maintained densest canopies, but were also characterized by a reduction in cane periderm formation, wine aroma intensity, wine quality, and, during 1984, 0 Brix, duster weight, and berries per duster. Effects of both training and pruning strategy on titratable acidity and pH were very small. Due to large and consistent gains in yield, improved budbreak and canopy fill, as weil as potential for mechanization of pruning, low cordon training is recommended for Riesling on non-divided canopies

Ionization, Kinematics, and Extent of the Diffuse Ionized Gas Halo of NGC 5775

We present key results from deep spectra of the Diffuse Ionized Gas (DIG) halo of the edge-on galaxy NGC 5775. [NII]6583 has been detected up to about z=13 kpc above the plane in one of two vertically oriented long slits -- making this the spiral galaxy with the greatest spectroscopically detected halo extent in emission. Key diagnostic line ratios have been measured up to about z=8 kpc, allowing the source of ionization and physical state to be probed. Ionization by a dilute radiation field from massive stars in the disk can explain some of the line ratio behavior, but departures from this picture are clearly indicated, most strongly by the rise of [OIII]/Halpha with z. Velocities of the gas in both slits approach the systemic velocity of the galaxy at several kpc above the plane. We interpret this trend as a decrease in rotation velocity with z, with essentially no rotation at heights of several kpc. Such a trend was observed in the edge-on galaxy NGC 891, but here much more dramatically. This falloff is presumably due to the gravitational potential changing with z, but will also depend on the hydrodynamic nature of the disk-halo cycling of gas and projection effects. More detailed modeling of the ionization and kinematics of this and other edge-ons will be presented in future papers.Comment: figures 1, 2a-d and 3 included. ApJ Letters, in pres

Learning to fear a second-order stimulus following vicarious learning

Vicarious fear learning refers to the acquisition of fear via observation of the fearful responses of others. The present study aims to extend current knowledge by exploring whether second-order vicarious fear learning can be demonstrated in children. That is, whether vicariously learnt fear responses for one stimulus can be elicited in a second stimulus associated with that initial stimulus. Results demonstrated that children’s (5–11 years) fear responses for marsupials and caterpillars increased when they were seen with fearful faces compared to no faces. Additionally, the results indicated a second-order effect in which fear-related learning occurred for other animals seen together with the fear-paired animal, even though the animals were never observed with fearful faces themselves. Overall, the findings indicate that for children in this age group vicariously learnt fear-related responses for one stimulus can subsequently be observed for a second stimulus without it being experienced in a fear-related vicarious learning event. These findings may help to explain why some individuals do not recall involvement of a traumatic learning episode in the development of their fear of a specific stimulus

Preventing the development of observationally learnt fears in children by devaluing the model's negative response

Vicarious learning has become an established indirect pathway to fear acquisition. It is generally accepted that associative learning processes underlie vicarious learning; however, whether this association is a form of conditioned stimulus-unconditioned stimulus (CS-US) learning or stimulus–response (CS-CR) learning remains unclear. Traditionally, these types of learning can be dissociated in a US revaluation procedure. The current study explored the effects of post-vicarious learning US revaluation on acquired fear responses. Ninety-four children (46 males and 48 females) aged 6 to 10 years first viewed either a fear vicarious learning video or a neutral vicarious learning video followed by random allocation to one of three US revaluation conditions: inflation; deflation; or control. Inflation group children were presented with still images of the adults in the video and told that the accompanying sound and image of a very fast heart rate monitor belonged to the adult. The deflation group were shown the same images but with the sound and image of a normal heart rate. The control group received no US revaluation. Results indicated that inflating how scared the models appeared to be did not result in significant increases in children’s fear beliefs, avoidance preferences, avoidance behavior or heart rate for animals above increases caused by vicarious learning. In contrast, US devaluation resulted in significant decreases in fear beliefs and avoidance preferences. Thus, the findings provide evidence that CS-US associations underpin vicarious learning and suggest that US devaluation may be a successful method for preventing children from developing fear beliefs following a traumatic vicarious learning episode with a stimulus

Effect of vicarious fear learning on children’s heart rate responses and attentional bias for novel animals

Research with children has shown that vicarious learning can result in changes to 2 of Lang’s (1968) 3 anxiety response systems: subjective report and behavioral avoidance. The current study extended this research by exploring the effect of vicarious learning on physiological responses (Lang’s final response system) and attentional bias. The study used Askew and Field’s (2007) vicarious learning procedure and demonstrated fear-related increases in children’s cognitive, behavioral, and physiological responses. Cognitive and behavioral changes were retested 1 week and 1 month later, and remained elevated. In addition, a visual search task demonstrated that fear-related vicarious learning creates an attentional bias for novel animals, which is moderated by increases in fear beliefs during learning. The findings demonstrate that vicarious learning leads to lasting changes in all 3 of Lang’s anxiety response systems and is sufficient to create attentional bias to threat in children

MicroRNA-330-5p as a putative modulator of neoadjuvant chemoradiotherapy sensitivity in oesophageal adenocarcinoma

Oesophageal adenocarcinoma (OAC) is the sixth most common cause of cancer deaths worldwide, and the 5-year survival rate for patients diagnosed with the disease is approximately 17%. The standard of care for locally advanced disease is neoadjuvant chemotherapy or, more commonly, combined neoadjuvant chemoradiation therapy (neo-CRT) prior to surgery. Unfortunately, ~60-70% of patients will fail to respond to neo-CRT. Therefore, the identification of biomarkers indicative of patient response to treatment has significant clinical implications in the stratification of patient treatment. Furthermore, understanding the molecular mechanisms underpinning tumour response and resistance to neo-CRT will contribute towards the identification of novel therapeutic targets for enhancing OAC sensitivity to CRT. MicroRNAs (miRNA/miR) function to regulate gene and protein expression and play a causal role in cancer development and progression. MiRNAs have also been identified as modulators of key cellular pathways associated with resistance to CRT. Here, to identify miRNAs associated with resistance to CRT, pre-treatment diagnostic biopsy specimens from patients with OAC were analysed using miRNA-profiling arrays. In pre-treatment biopsies miR-330-5p was the most downregulated miRNA in patients who subsequently failed to respond to neo-CRT. The role of miR-330 as a potential modulator of tumour response and sensitivity to CRT in OAC was further investigated in vitro. Through vector-based overexpression the E2F1/p-AKT survival pathway, as previously described, was confirmed as a target of miR-330 regulation. However, miR-330-mediated alterations to the E2F1/p-AKT pathway were insufficient to significantly alter cellular sensitivity to chemotherapy (cisplatin and 5-flurouracil). In contrast, silencing of miR-330-5p enhanced, albeit subtly, cellular resistance to clinically relevant doses of radiation. This study highlights the need for further investigation into the potential of miR-330-5p as a predictive biomarker of patient sensitivity to neo-CRT and as a novel therapeutic target for manipulating cellular sensitivity to neo-CRT in patients with OAC