Protein folding and the robustness of cells

The intricate intracellular infrastructure of all known life forms is based on proteins. The folded shape of a protein determines both the protein’s function and the set of molecules it will bind to. This tight coupling between a protein’s function and its interconnections in the molecular interaction network has consequences for the molecular course of evolution. It is also counter to human engineering approaches. Here we report on a simulation study investigating the impact of random errors in an abstract metabolic network of 500 enzymes. Tight coupling between function and interconnectivity of nodes is compared to the case where these two properties are independent. Our results show that the model system under consideration is more robust if function and interconnection are intertwined. These findings are discussed in the context of nanosystems engineering

Relevance of Social, Economic, and Environmental Impacts on Residents’ Satisfaction with the Public Administration of Tourism

Those in charge of tourism destinations face the need to create tourism development models compatible with the essence of the localities that they manage. These models have to be sustainable, both environmentally and socially, and also must become drivers of the local economy. However, tourists also generate negative impacts in the locality which, when they are perceived by the residents, can give rise to a rejection of visitors. Hence, improving the tourism management is necessary. This is why to know the residents’ perceptions about the impacts of tourism is essential. Moreover, measuring the impact effects on their satisfaction with the public administration of the destination can be of great usefulness. This study falls into this research line, as it proposes a model to measure these impacts and their effect on satisfaction. To do so, an empirical study is performed among residents in the city of Seville (southern Spain, one of the most visited destinations in the world), based on subjective economic, social, and environmental indicators. The results show that the citizens value three types of impacts, the social impact coming after the economic impact as to its influence on their satisfaction with the administration. Based on this, we postulate that the efforts made to attract events to the city, or to improve connections to access a broader market, must be approached as public procurements in which selection criteria that are compatible with the destination’s positioning and strategy prevail. Social and environmental criteria should be considered among these criteria

An investigation of public and private R&D partnership

16th Annual Meeting of the Academy of Management, Toronto, Ontario, Canada, August 2000 : A New TimeIn this paper we investigate public and private research and development relationships with respect to their performance. The study utilizes a database of over 250 of these relationships, funded by Spanish government agencies. The methodology includes the application of data envelopment analysis (DEA) to determine the relative performance ("efficiency") of the various projects

Foliar nutrient levels of native tree species from Central Amazonia. I. Inundation forests

The study of the leaf size spectra and foliar concentrations of N, P, K, Ca, Mg and Na of 52 species sampled in three Central-Amazon inundation forests (2 várzea sites, 1 igapó site) yielded signifìcant differences between várzea and igapó forests. The várzea foliage consists of larger and less heavy leaves with elemental concentrations being high even by tropical standards. The igapó foliage consists of relatively small leaves which are heavier, but much lower in the studied elements. The igapó leaves are supposed to be sclerophyllous and evergreen

Factores ambientales condicionantes de la presencia de la lagartija de Carbonell Podarcis carbonelli (Pérez-Mellado, 1981) en la comarca de Doñana

The Carbonell lizard (Podarcis carbonelli) is an Iberian endemism. The region of Doñana is its southernmost and more isolated stronghold. We used logistic regressions to investigate the factors conditioning the presence of this lizard in Doñana. All selected models retained the distance to the coast as the main variable. This variable is related with less humidity and more continental climatic conditions, including more extreme temperatures, when further from the coast. This climatic factor was observed both spatially and temporarily, with adult lizards drastically reducing their activity both in winter and in summer. We observed juveniles from June to January, with a maximum in September. Scrubland management was another important environmental factor affecting the presence of lizards. The probability of finding this species was higher where the scrubland was partially cleared, and lower in areas with a high plant cover (hygrophytic scrubland) or in areas with sparse vegetation (dune scrubland), probably due to a lower amount of incident light and less protection when moving between refuges, respectively.La lagartija de Carbonell es un endemismo ibérico que encuentra en la comarca de Doñana el reducto más meridional y aislado de su área de distribución. Mediante el uso de regresiones logísticas se ha intentado conocer qué factores condicionan la presencia de la lagartija de Carbonell en Doñana. La variable principal de los distintos modelos fue la distancia a la costa. Ésta se relaciona con un menor grado de humedad y una mayor continentalidad del clima, con temperaturas más extremas, a medida que nos alejamos del mar. Este condicionante climático se ha observado tanto espacial como temporalmente, reduciéndose drásticamente la actividad de los animales adultos en verano e invierno. Los juveniles se observan desde junio a enero con un máximo en septiembre. Otro de los factores importantes ha resultado ser la gestión del matorral. Se ha observado una mayor probabilidad de encontrar la lagartija de Carbonell en zonas en las que el matorral ha sido parcialmente clareado, ya que evita los lugares con elevadas densidades de plantas (matorral hidrofílico), que reducirían el paso de la luz, o con una densidad muy baja (matorral de las dunas), que no permitiría el tránsito seguro entre refugios

RPE and velocity how intensity markers of bench press exercise

El propósito de esta investigación fue analizar la relación entre la evolución de la velocidad media (Velmedia) y los valores de la escala OMNI-RES, en 3 intensidades (carga Inicial [CI], máxima potencia [MP] y repetición máxima [RM]). 38 sujetos divididos en dos grupos: Entrenados (G1, n = 19) y No Entrenados (G2, n = 19) realizaron un test incremental de cargas en el ejercicio del press de banca. En la percepción subjetiva del esfuerzo (RPE) no se encontraron diferencias significativas entre ambos grupos. El análisis de la Velmedia mostró diferencias significativas tanto en la MP como en la RM. La OMNI-RES es un buen método para cuantificar la intensidad en el ejercicio del press de banca, aunque sería aconsejable acompañar este valor con otra medida de intensidad como la Velmedia. De esta forma, se podría ajustar mejor la intensidad real realizada en las diferentes series de entrenamient

Performance of Slow-Growing Chickens Fed with Tenebrio molitor Larval Meal as a Full Replacement for Soybean Meal

Insect larval meal is an increasingly common protein source in poultry systems. In this study, the effect of replacing soybean meal with Tenebrio molitor larval meal on the performance of slow-growing chickens was assessed. A total of 128 one-day-old chickens (Colorield) were randomly divided into a control group (C) (n = 64), fed with soybean meal, and an experimental group (TM) (n = 64), fed with T. molitor larvae meal. The chicks were slaughtered after 95 days. Three different isoenergetic and isoproteic diets (F1, F2 and F3) were used for each group. The F1 diet resulted in higher body weight gain and higher feed and water intakes in group C, but a lower feed conversion ratio. Contrarily, diets F2 and F3 did not produce differences in the studied parameters between the two groups, except for body weight gain in the case of diet F2, which was highest in group C. Therefore, weight gain and feed and water intakes were significantly higher in group C, but there were no differences in feed conversion ratio or live weight. In conclusion, the total replacement of soybean meal with T. molitor larvae meal resulted in a reduction in feed intake and a consequent reduction in weight. During this period, partial rather than total substitution may be recommended. © 2022 by the authors. Licensee MDPI, Basel, Switzerland