517 research outputs found
QCD axion and quintessential axion
The axion solution of the strong CP problem is reviewed together with the
other strong CP solutions. We also point out the quintessential
axion(quintaxion) whose potential can be extremely flat due to the tiny ratio
of the hidden sector quark mass and the intermediate hidden sector scale. The
quintaxion candidates are supposed to be the string theory axions, the model
independent or the model dependent axions.Comment: 15 pages. Talk presented at Castle Ringberg, June 9-14, 200
True Neutrality as a New Type of Flavour
A classification of leptonic currents with respect to C-operation requires
the separation of elementary particles into the two classes of vector C-even
and axial-vector C-odd character. Their nature has been created so that to each
type of lepton corresponds a kind of neutrino. Such pairs are united in
families of a different C-parity. Unlike the neutrino of a vector type, any
C-noninvariant Dirac neutrino must have his Majorana neutrino. They constitute
the purely neutrino families. We discuss the nature of a corresponding
mechanism responsible for the availability in all types of axial-vector
particles of a kind of flavour which distinguishes each of them from others by
a true charge characterized by a quantum number conserved at the interactions
between the C-odd fermion and the field of emission of the corresponding types
of gauge bosons. This regularity expresses the unidenticality of truly neutral
neutrino and antineutrino, confirming that an internal symmetry of a
C-noninvariant particle is described by an axial-vector space. Thereby, a true
flavour together with the earlier known lepton flavour predicts the existence
of leptonic strings and their birth in single and double beta decays as a unity
of flavour and gauge symmetry laws. Such a unified principle explains the
availability of a flavour symmetrical mode of neutrino oscillations.Comment: 19 pages, LaTex, Published version in IJT
The semi-classical expansion and resurgence in gauge theories: new perturbative, instanton, bion, and renormalon effects
We study the dynamics of four dimensional gauge theories with adjoint
fermions for all gauge groups, both in perturbation theory and
non-perturbatively, by using circle compactification with periodic boundary
conditions for the fermions. There are new gauge phenomena. We show that, to
all orders in perturbation theory, many gauge groups are Higgsed by the gauge
holonomy around the circle to a product of both abelian and nonabelian gauge
group factors. Non-perturbatively there are monopole-instantons with fermion
zero modes and two types of monopole-anti-monopole molecules, called bions. One
type are "magnetic bions" which carry net magnetic charge and induce a mass gap
for gauge fluctuations. Another type are "neutral bions" which are magnetically
neutral, and their understanding requires a generalization of multi-instanton
techniques in quantum mechanics - which we refer to as the
Bogomolny-Zinn-Justin (BZJ) prescription - to compactified field theory. The
BZJ prescription applied to bion-anti-bion topological molecules predicts a
singularity on the positive real axis of the Borel plane (i.e., a divergence
from summing large orders in peturbation theory) which is of order N times
closer to the origin than the leading 4-d BPST instanton-anti-instanton
singularity, where N is the rank of the gauge group. The position of the
bion--anti-bion singularity is thus qualitatively similar to that of the 4-d IR
renormalon singularity, and we conjecture that they are continuously related as
the compactification radius is changed. By making use of transseries and
Ecalle's resurgence theory we argue that a non-perturbative continuum
definition of a class of field theories which admit semi-classical expansions
may be possible.Comment: 112 pages, 7 figures; v2: typos corrected, discussion of
supersymmetric models added at the end of section 8.1, reference adde
Yoga vs. physical therapy vs. education for chronic low back pain in predominantly minority populations: Study protocol for a randomized controlled trial
Background: Chronic low back pain causes substantial morbidity and cost to society while disproportionately impacting low-income and minority adults. Several randomized controlled trials show yoga is an effective treatment. However, the comparative effectiveness of yoga and physical therapy, a common mainstream treatment for chronic low back pain, is unknown.Methods/Design: This is a randomized controlled trial for 320 predominantly low-income minority adults with chronic low back pain, comparing yoga, physical therapy, and education. Inclusion criteria are adults 18-64 years old with non-specific low back pain lasting ≥12 weeks and a self-reported average pain intensity of ≥4 on a 0-10 scale. Recruitment takes place at Boston Medical Center, an urban academic safety-net hospital and seven federally qualified community health centers located in diverse neighborhoods. The 52-week study has an initial 12-week Treatment Phase where participants are randomized in a 2:2:1 ratio into i) a standardized weekly hatha yoga class supplemented by home practice; ii) a standardized evidence-based exercise therapy protocol adapted from the Treatment Based Classification method, individually delivered by a physical therapist and supplemented by home practice; and iii) education delivered through a self-care book. Co-primary outcome measures are 12-week pain intensity measured on an 11-point numerical rating scale and back-specific function measured using the modified Roland Morris Disability Questionnaire. In the subsequent 40-week Maintenance Phase, yoga participants are re-randomized in a 1:1 ratio to either structured maintenance yoga classes or home practice only. Physical therapy participants are similarly re-randomized to either five booster sessions or home practice only. Education participants continue to follow recommendations of educational materials. We will also assess cost effectiveness from the perspectives of the individual, insurers, and society using claims databases, electronic medical records, self-report cost data, and study records. Qualitative data from interviews will add subjective detail to complement quantitative data.Trial registration: This trial is registered in ClinicalTrials.gov, with the ID number: NCT01343927. © 2014 Saper et al.; licensee BioMed Central Ltd
Stochastic Gravity: Theory and Applications
Whereas semiclassical gravity is based on the semiclassical Einstein equation
with sources given by the expectation value of the stress-energy tensor of
quantum fields, stochastic semiclassical gravity is based on the
Einstein-Langevin equation, which has in addition sources due to the noise
kernel. In the first part, we describe the fundamentals of this new theory via
two approaches: the axiomatic and the functional. In the second part, we
describe three applications of stochastic gravity theory. First, we consider
metric perturbations in a Minkowski spacetime, compute the two-point
correlation functions of these perturbations and prove that Minkowski spacetime
is a stable solution of semiclassical gravity. Second, we discuss structure
formation from the stochastic gravity viewpoint. Third, we discuss the
backreaction of Hawking radiation in the gravitational background of a black
hole and describe the metric fluctuations near the event horizon of an
evaporating black holeComment: 100 pages, no figures; an update of the 2003 review in Living Reviews
in Relativity gr-qc/0307032 ; it includes new sections on the Validity of
Semiclassical Gravity, the Stability of Minkowski Spacetime, and the Metric
Fluctuations of an Evaporating Black Hol
Immunodetection of nmt55/p54(nrb) isoforms in human breast cancer
BACKGROUND: We previously identified and characterized a novel 55 kDa nuclear protein, termed nmt55/p54(nrb), whose expression was decreased in a subset of human breast tumors. The objective of this study was to determine if this reduced expression in human breast tumors was attributed to the regulation of mRNA transcription or the presence of altered forms of this protein. RESULTS: Northern blot analysis and ribonuclease protection assay indicated that nmt55/p54(nrb) mRNA is expressed at varying levels in estrogen receptor positive (ER+) and estrogen receptor negative (ER-) human breast tumors suggesting that reduced expression of nmt55/p54(nrb) protein in ER- tumors was not due to transcriptional regulation. To determine if multiple protein isoforms are expressed in breast cancer, we utilized Western blot and immunohistochemical analyses, which revealed the expression of an nmt55/p54(nrb) protein isoform in a subset of ER+ tumors. This subset of ER+ human breast tumors expressed an altered form of nmt55/p54(nrb) that was undetectable with an amino-terminal specific antibody suggesting that this isoform contains alterations or modifications within the amino terminal domain. CONCLUSIONS: Our study indicates that nmt55/p54(nrb) protein is post-transcriptionally regulated in human breast tumors leading to reduced expression in ER- tumors and the expression of an amino terminal altered isoform in a subset of ER+ tumors. The potential involvement of nmt55/p54(nrb) in RNA binding and pre-mRNA splicing may be important for normal cell growth and function; thus, loss or alteration of protein structure may contribute to tumor growth and progression
Epithelial-Mesenchymal Transition in Cells Expanded In Vitro from Lineage-Traced Adult Human Pancreatic Beta Cells
BACKGROUND: In-vitro expansion of functional beta cells from adult human islets is an attractive approach for generating an abundant source of cells for beta-cell replacement therapy of diabetes. Using genetic cell-lineage tracing we have recently shown that beta cells cultured from adult human islets undergo rapid dedifferentiation and proliferate for up to 16 population doublings. These cells have raised interest as potential candidates for redifferentiation into functional insulin-producing cells. Previous work has associated dedifferentiation of cultured epithelial cells with epithelial-mesenchymal transition (EMT), and suggested that EMT generates cells with stem cell properties. Here we investigated the occurrence of EMT in these cultures and assessed their stem cell potential. METHODOLOGY/PRINCIPAL FINDINGS: Using cell-lineage tracing we provide direct evidence for occurrence of EMT in cells originating from beta cells in cultures of adult human islet cells. These cells express multiple mesenchymal markers, as well as markers associated with mesenchymal stem cells (MSC). However, we do not find evidence for the ability of such cells, nor of cells in these cultures derived from a non-beta-cell origin, to significantly differentiate into mesodermal cell types. CONCLUSIONS/SIGNIFICANCE: These findings constitute the first demonstration based on genetic lineage-tracing of EMT in cultured adult primary human cells, and show that EMT does not induce multipotency in cells derived from human beta cells
Stochastic Gravity: Theory and Applications
Whereas semiclassical gravity is based on the semiclassical Einstein equation
with sources given by the expectation value of the stress-energy tensor of
quantum fields, stochastic semiclassical gravity is based on the
Einstein-Langevin equation, which has in addition sources due to the noise
kernel.In the first part, we describe the fundamentals of this new theory via
two approaches: the axiomatic and the functional. In the second part, we
describe three applications of stochastic gravity theory. First, we consider
metric perturbations in a Minkowski spacetime: we compute the two-point
correlation functions for the linearized Einstein tensor and for the metric
perturbations. Second, we discuss structure formation from the stochastic
gravity viewpoint. Third, we discuss the backreaction of Hawking radiation in
the gravitational background of a quasi-static black hole.Comment: 75 pages, no figures, submitted to Living Reviews in Relativit
Gamma radiation induces hydrogen absorption by copper in water
One of the most intricate issues of nuclear power is the long-term safety of repositories for radioactive waste. These repositories can have an impact on future generations for a period of time orders of magnitude longer than any known civilization. Several countries have considered copper as an outer corrosion barrier for canisters containing spent nuclear fuel. Among the many processes that must be considered in the safety assessments, radiation induced processes constitute a key-component. Here we show that copper metal immersed in water uptakes considerable amounts of hydrogen when exposed to Îł-radiation. Additionally we show that the amount of hydrogen absorbed by copper depends on the total dose of radiation. At a dose of 69 kGy the uptake of hydrogen by metallic copper is 7 orders of magnitude higher than when the absorption is driven by H2(g) at a pressure of 1 atm in a non-irradiated dry system. Moreover, irradiation of copper in water causes corrosion of the metal and the formation of a variety of surface cavities, nanoparticle deposits, and islands of needle-shaped crystals. Hence, radiation enhanced uptake of hydrogen by spent nuclear fuel encapsulating materials should be taken into account in the safety assessments of nuclear waste repositories.Peer reviewe
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