EXPERIMENTAL DEVELOPMENT AND MOLECULAR DOCKING: NANOSTRUCTURED LIPID CARRIERS (NLCs) OF COENZYME Q10 USING STEARIC ACID AND DIFFERENT LIQUID LIPIDS AS LIPID MATRIX

Objective: To develop coenzyme Q10 (co-Q10) nanostructured lipid carriers (NLCs) using stearic acid (SA) and various liquid lipids with different lipophilicity as well as highlights the use of in silico studies for predicting and elucidating the interaction of drug-lipid used as carries in NLCs, at the molecular level. Methods: The co-Q10 NLCs were prepared using SA as solid lipid and oleic acid (OA), isopropyl myristate (IPM), as well as isopropyl palmitate (IPP) as liquid lipids by the high shear homogenization method. Firstly, the formulas were optimized by the appropriate required HLB (rHLB). The optimized NLCs were characterized in the particle size, distribution of particle size, zeta potential, crystallinity behavior, Fourier transform infrared (FT-IR) spectra, morphology, entrapment efficiency (EE), drug loading (DL), and pH value. The interaction of drug-lipids in silico was studied using the AutoDock Vina program. Results: The co-Q10 NLCs using SA and the various liquid lipid possessed the mean particle size, polydispersity index (PDI), zeta potential, EE, DL, and pH values were 180 to 350 nm,<0.5,<-30 mV, 83 to 88%, 10 to 11%, and 5.0 to 5.6, respectively. The EE and DL of co-Q10 NLCs increased with decreasing in binding energy (∆G) in silico. Conclusion: The co-Q10 NLCs using SA as solid lipid and OA, IPM, as well as IPP as liquid lipids were developed successfully. Furthermore, in silico study by molecular docking is a potential approach in predicting and elucidating the interaction of drug-lipid in the development of NLCs formulation

PENGARUH PENGELOLAAN KEUANGAN DAN SISTEM INFORMASI AKUNTANSI TERHADAP TRANSPARANSI KINERJA KEUANGAN BUMDES

This study aims to determine the effect of financial management variables and accounting information systems on financial performance transparency variables. The research was conducted using qualitative methods and using a case study approach, and samples were taken from 32 respondents. This research was conducted in BUMDes Sauyunan, Cihideung Village, Parongpong District, West Bandung Regency with the aim of increasing understanding in managing BUMDes finance through the System Information Accounting. Hypothesis testing in this study using SPSS tools. The results showed that the Financial Management variable (X1) had no effect on the Financial Performance Transparency variable (Y), while the Accounting Information System variable (X2) had an effect on the Financial Performance Transparency variable (Y)

Membaca Pola Perkalian Bilangan Sebelas

Penelitian ini merupakan penelitian deskriptif kualitatif yang bertujuan untuk mendeskripsikan pemahaman membaca pola perkalian sebelas. Pemahaman membaca pola perkalian sebelas terdiri dari pemahaman konsep dan cara penggunaannya. Tujuan penelitian ini adalah cara cepat menghitung perkalian sebelas. Subjek dalam penelitian ini adalah siswa kelas VI. Pengumpulan data dilakukan melalui tes tertulis serta wawancara. Berdasarkan hasil penelitian, diketahui bahwa kategori kecerdasan siswa yang berbeda, menghasilkan kemampuan pemahaman konsep matematis yang berbeda pula. Apabila ditinjau dari pola struktur berpikir siswa, sebenarnya siswa sudah memiliki pemahaman yang dapat dimanfaatkan untuk membaca pola perkalian bilangan sebelas. Tetapi siswa sulit untuk mengkomunikasikan hasil dari yang mereka kerjakan. Salah satu siswa yang menyatakan, bahwa untuk mengerjakan soal perkalian bilangan sebelas ternyata lebih mudah dan cepat dengan menggunakan pola yang sudah ditemukannya melalui lembar kerja siswa yang mereka kerjakan        &nbsp