A Ph/enzyme-responsive Polymer Film Consisting Of Eudragit® Fs 30 D And Arabinoxylane As A Potential Material Formulation For Colon-specific Drug Delivery System

Polymer film based on pH-dependent Eudragit® FS 30 D acrylic polymer in association with arabinoxylane, a polysaccharide issued from gum psyllium, was produced by way of solvent casting. Physical-chemical characterization of the polymer film samples was performed by means of thermogravimetry (TGA), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). Furthermore, water-equilibrium swelling index (Is) and weight loss of the films in KCl buffer solution of pH 1.2, in KH 2PO 4 buffer solution of pH 5.0, or in KH 2PO 4 buffer solution of pH 5.0 consisting of 4% enzyme Pectinex® 3X-L (w/v) were also carried out for the film characterization. No chemical interactions between the Eudragit® FS 30 D and the arabinoxylane polymer chains were evidenced, thus suggesting that the film-forming polymer structure was obtained from a physical mixture of both polymers. The arabinoxylane-loader films showed a more pronounced weight loss after their immersion in buffer solution containing enzyme Pectinex® 3X-L. The introduction of the arabinoxylane makes the film more susceptible to undergo an enzymatic degradation. This meant that the enzyme-dependent propriety issued from the arabinoxylane has been imprinted into the film formulation. This type of polymer film is an interesting system for applications in colon-specific drug delivery system. © 2012 Informa Healthcare USA, Inc.174429436Souto-Maior, J.F.A., Reis, A.V., Pedreiro, L.M., Cavalcanti, O.A., Phosphated crosslinked pectin as a potential excipient for specific drug delivery: Preparation and physicochemical characterization (2010) Polym. 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