1,119 research outputs found
Parametric optimization for terabit perpendicular recording
The design of media for ultrahigh-density perpendicular recording is discussed in depth. Analytical and semianalytical models are developed to determine the constraints upon the media to fulfill requirements of writability and thermal stability, and the effect of intergranular exchange coupling is examined. The role of vector fields during the write process is examined, and it is shown that one-dimensional models of perpendicular recording have significant deficiencies. A micromagnetic model is described and the results of simulations of recording undertaken with the model are presented. The paper demonstrates that there is no physical reason why perpendicular recording should not be possible at or above 1 Tb/in(2)
Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours
AbstractMetastatic cancer in adults usually has a fatal outcome. In contrast, advanced testicular germ cell tumours are cured in over 80% of patients using cisplatin-based combination chemotherapy [1]. An understanding of why these cells are sensitive to chemotherapeutic drugs is likely to have implications for the treatment of other types of cancer. Earlier measurements indicate that testis tumour cells are hypersensitive to cisplatin and have a low capacity to remove cisplatin-induced DNA damage from the genome [2,3]. We have investigated the nucleotide excision repair (NER) capacity of extracts from the well-defined 833K and GCT27 human testis tumour cell lines. Both had a reduced ability to carry out the incision steps of NER in comparison with extracts from known repair-proficient cells. Immunoblotting revealed that the testis tumour cells had normal amounts of most NER proteins, but low levels of the xeroderma pigmentosum group A protein (XPA) and the ERCC1âXPF endonuclease complex. Addition of XPA specifically conferred full NER capacity on the testis tumour extracts. These results show that a low XPA level in the testis tumour cell lines is sufficient to explain their poor ability to remove cisplatin adducts from DNA and might be a major reason for the high cisplatin sensitivity of testis tumours. Targeted inhibition of XPA could sensitise other types of cells and tumours to cisplatin and broaden the usefulness of this chemotherapeutic agent
Optical properties of tungsten thin films perforated with a bidimensional array of subwavelength holes
We present a theorical investigation of the optical transmission of a
dielectric grating carved in a tungsten layer. For appropriate wavelengths
tungsten shows indeed a dielectric behaviour. Our numerical simulations leads
to theoretical results similar to those found with metallic systems studied in
earlier works. The interpretation of our results rests on the idea that the
transmission is correlated with the resonant response of eigenmodes coupled to
evanescent diffraction orders.Comment: 4 pages, 3 figure
Strong Discontinuities in the Complex Photonic Band Structure of Transmission Metallic Gratings
Complex photonic band structures (CPBS) of transmission metallic gratings
with rectangular slits are shown to exhibit strong discontinuities that are not
evidenced in the usual energetic band structures. These discontinuities are
located on Wood's anomalies and reveal unambiguously two different types of
resonances, which are identified as horizontal and vertical surface-plasmon
resonances. Spectral position and width of peaks in the transmission spectrum
can be directly extracted from CPBS for both kinds of resonances.Comment: 4 pages, 4 figures, REVTeX version
Gender violence in schools: taking the âgirls-as-victimsâ discourse forward
This paper draws attention to the gendered nature of violence in schools. Recent recognition that schools can be violent places has tended to ignore the fact that many such acts originate in unequal and antagonistic gender relations, which are tolerated and ânormalisedâ by everyday school structures and processes. After examining some key concepts and definitions, we provide a brief overview of the scope and various manifestations of gender violence in schools, noting that most research to date has focused on girls as victims of gender violence within a heterosexual context and ignores other forms such as homophobic and girl violence. We then move on to look at a few interventions designed to address gender violence in schools in the developing world and end by highlighting the need for more research and improved understanding of the problem and how it can be addressed
Accurate spline solutions of the Dirac equation with parity-nonconserving potential
The complete system of the B-spline solutions for the Dirac equation with the
parity-nonconserving (PNC) weak interaction effective potential is obtained.
This system can be used for the accurate evaluation of the radiative
corrections to the PNC amplitudes in the multicharged ions and neutral atoms.
The use of the scaling procedure allows for the evaluation of the PNC matrix
elements with relative accuracy .Comment: 7 page
Radiative Corrections to One-Photon Decays of Hydrogenic Ions
Radiative corrections to the decay rate of n=2 states of hydrogenic ions are
calculated. The transitions considered are the M1 decay of the 2s state to the
ground state and the E1(M2) decays of the and states to
the ground state. The radiative corrections start in order , but the method used sums all orders of . The leading
correction for the E1 decays is calculated and compared
with the exact result. The extension of the calculational method to parity
nonconserving transitions in neutral atoms is discussed.Comment: 22 pages, 2 figure
High-precision determination of transition amplitudes of principal transitions in Cs from van der Waals coefficient C_6
A method for determination of atomic dipole matrix elements of principal
transitions from the value of dispersion coefficient C_6 of molecular
potentials correlating to two ground-state atoms is proposed. The method is
illustrated on atomic Cs using C_6 deduced from high-resolution Feshbach
spectroscopy. The following reduced matrix elements are determined < 6S_{1/2}
|| D || 6P_{1/2} > =4.5028(60) |e| a0 and
=6.3373(84) |e| a0 (a0= 0.529177 \times 10^{-8} cm.) These matrix elements are
consistent with the results of the most accurate direct lifetime measurements
and have a similar uncertainty. It is argued that the uncertainty can be
considerably reduced as the coefficient C_6 is constrained further.Comment: 4 pages; 3 fig
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