47 research outputs found
Breaking CPT by mixed non-commutativity
The mixed component of the non-commutative parameter \theta_{\mu M}, where
\mu = 0,1,2,3 and M is an extra dimensional index may violate four-dimensional
CPT invariance. We calculate one and two-loop induced couplings of \theta_{\mu
5} with the four-dimensional axial vector current and with the CPT odd dim=6
operators starting from five-dimensional Yukawa and U(1) theories. The
resulting bounds from clock comparison experiments place a stringent constraint
on \theta_{\mu 5}, |\theta_{\mu 5}|^{-1/2} > 5\times 10^{11} GeV. The orbifold
projection and/or localization of fermions on a 3-brane lead to CPT-conserving
physics, in which case the constraints on \theta{\mu 5} are softened.Comment: 4 pages, latex, 1 figur
A new photon recoil experiment: towards a determination of the fine structure constant
We report on progress towards a measurement of the fine structure constant to
an accuracy of or better by measuring the ratio of the
Planck constant to the mass of the cesium atom. Compared to similar
experiments, ours is improved in three significant ways: (i) simultaneous
conjugate interferometers, (ii) multi-photon Bragg diffraction between same
internal states, and (iii) an about 1000 fold reduction of laser phase noise to
-138 dBc/Hz. Combining that with a new method to simultaneously stabilize the
phases of four frequencies, we achieve 0.2 mrad effective phase noise at the
location of the atoms. In addition, we use active stabilization to suppress
systematic effects due to beam misalignment.Comment: 12 pages, 9 figure
Zitterbewegung in External Magnetic Field: Classic versus Quantum Approach
We investigate variations of the Zitterbewegung frequency of electron due to
an external static and uniform magnetic field employing the expectation value
quantum approach, and compare our results with the classical model of spinning
particles. We demonstrate that these two so far compatible approaches are not
in agreement in the presence of an external uniform static magnetic field, in
which the classical approach breaks the usual symmetry of free particles and
antiparticles states, i.e. it leads to CP violation. Hence, regarding the
Zitterbewegung frequency of electron, the classical approach in the presence of
an external magnetic field is unlikely to correctly describe the spin of
electron, while the quantum approach does, as expected. We also show that the
results obtained via the expectation value are in close agreement with the
quantum approach of the Heisenberg picture derived in the literature. However,
the method we use is capable of being compared with the classical approach
regarding the spin aspects. The classical interpretation of spin produced by
the altered Zitterbewegung frequency, in the presence of an external magnetic
field, are discussed.Comment: 16 pages, no figure
Coherent matter wave inertial sensors for precision measurements in space
We analyze the advantages of using ultra-cold coherent sources of atoms for
matter-wave interferometry in space. We present a proof-of-principle experiment
that is based on an analysis of the results previously published in [Richard et
al., Phys. Rev. Lett., 91, 010405 (2003)] from which we extract the ratio h/m
for 87Rb. This measurement shows that a limitation in accuracy arises due to
atomic interactions within the Bose-Einstein condensate
Assessment of the rapid test based on an immunochromatography technique for detecting anti-Treponema pallidum antibodies
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume
The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer’s Disease (AD). Whilst studies have reported associations with AD risk and related phenotypes, there remains a lack of consensus on these associations. Here we aimed to comprehensively investigate the relationship between five recognised measures of age acceleration, based on DNA methylation patterns (DNAm age), and cross-sectional and longitudinal cognition and AD-related neuroimaging phenotypes (volumetric MRI and Amyloid-β PET) in the Australian Imaging, Biomarkers and Lifestyle (AIBL) and the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Significant associations were observed between age acceleration using the Hannum epigenetic clock and cross-sectional hippocampal volume in AIBL and replicated in ADNI. In AIBL, several other findings were observed cross-sectionally, including a significant association between hippocampal volume and the Hannum and Phenoage epigenetic clocks. Further, significant associations were also observed between hippocampal volume and the Zhang and Phenoage epigenetic clocks within Amyloid-β positive individuals. However, these were not validated within the ADNI cohort. No associations between age acceleration and other Alzheimer’s disease-related phenotypes, including measures of cognition or brain Amyloid-β burden, were observed, and there was no association with longitudinal change in any phenotype. This study presents a link between age acceleration, as determined using DNA methylation, and hippocampal volume that was statistically significant across two highly characterised cohorts. The results presented in this study contribute to a growing literature that supports the role of epigenetic modifications in ageing and AD-related phenotypes
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference
The heterogeneity of neurodegenerative diseases is a key confound to disease understanding and treatment development, as study cohorts typically include multiple phenotypes on distinct disease trajectories. Here we introduce a machine-learning technique\u2014Subtype and Stage Inference (SuStaIn)\u2014able to uncover data-driven disease phenotypes with distinct temporal progression patterns, from widely available cross-sectional patient studies. Results from imaging studies in two neurodegenerative diseases reveal subgroups and their distinct trajectories of regional neurodegeneration. In genetic frontotemporal dementia, SuStaIn identifies genotypes from imaging alone, validating its ability to identify subtypes; further the technique reveals within-genotype heterogeneity. In Alzheimer\u2019s disease, SuStaIn uncovers three subtypes, uniquely characterising their temporal complexity. SuStaIn provides fine-grained patient stratification, which substantially enhances the ability to predict conversion between diagnostic categories over standard models that ignore subtype (p = 7.18
7 10 124 ) or temporal stage (p = 3.96
7 10 125 ). SuStaIn offers new promise for enabling disease subtype discovery and precision medicine