Nitrogen management for enhanced protein content in wheat in the Black Soil Zone

Non-Peer Reviewe

In vitro analyses of the toxicity, immunological, and gene expression effects of cobalt-chromium alloy wear debris and Co ions derived from metal-on-metal hip implants

Joint replacement has proven to be an extremely successful and cost-effective means of relieving arthritic pain and improving quality of life for recipients. Wear debris-induced osteolysis is, however, a major limitation and causes orthopaedic implant aseptic loosening, and various cell types including macrophages, monocytes, osteoblasts, and osteoclasts, are involved. During the last few years, there has been increasing concern about metal-on-metal (MoM) hip replacements regarding adverse reactions to metal debris associated with the MoM articulation. Even though MoM-bearing technology was initially aimed to extend the durability of hip replacements and to reduce the requirement for revision, they have been reported to release at least three times more cobalt and chromium ions than metal-on-polyethylene (MoP) hip replacements. As a result, the toxicity of metal particles and ions produced by bearing surfaces, both locally in the periprosthetic space and systemically, became a concern. Several investigations have been carried out to understand the mechanisms responsible for the adverse response to metal wear debris. This review aims at summarising in vitro analyses of the toxicity, immunological, and gene expression effects of cobalt ions and wear debris derived from MoM hip implants

Impact of tillage system, preceding crops, and P fertilizer on economic performance of flax production

Non-Peer ReviewedConservation farming is a system approach that considers all factors that affect production. Reduced tillage is one of the methods of conservation farming and is becoming increasingly popular on the prairie. This will impact directly on nutrient availability and on fertilizer and other chemical management decisions. Phosphorus (P) supply, and its availability in early stages of plant growth, is critical to the determination of optimum crop yield. Producers frequently avoid P application in flax and increase the P supply in the preceding crops since flax is very sensitive to seed-placed applications of monoammonium phosphate. Along with supplying residual P, a preceding crop such as wheat and canola may also have different impacts on yield and performance of flax depending upon its association with mycorrhizae. Since flax is a highly mycorrhizal crop, it is possible that mycorrhizal associations could be responsible for part of the positive response that flax shows in zero-till systems and the limited P response observed in recent studies. If so then P fertility requirements in flax could be greatly affected by the tillage system and by whether the preceding crop was mycorrhizal or not. Phosphorus fertilization could possibly be reduced or eliminated in flax grown in zero-till following a mycorrhizal crop and optimized in flax grown under conventional tillage management. By more clearly defining the P requirements of flax, canola and wheat grown under different management systems, it is possible to reduce inputs while maintaining or improving crop yield and quality. While many research studies have evaluated the economic impact of tillage systems on N fertility requirements, there has been very limited information available on the economic impact of tillage management and P phytoavailability or on the impact of the tillage system and past phosphorus fertilizer management on phosphorus response of crops. The objective of this study is to evaluate the economic impact of flax on tillage system, P fertilizer application, preceding crop, and level of P fertilizer applied in preceding crop

Spaces whose Pseudocompact Subspaces are Closed Subsets

[EN] Every first countable pseudocompact Tychonoff space X has the property that every pseudocompact subspace of X is a closed subset of X (denoted herein by “FCC”). We study the property FCC and several closely related ones, and focus on the behavior of extension and other spaces which have one or more of these properties. Characterization, embedding and product theorems are obtained, and some examples are given which provide results such as the following. There exists a separable Moore space which has no regular, FCC extension space. There exists a compact Hausdorff Fréchet space which is not FCC. There exists a compact Hausdorff Fréchet space X such that X, but not X2, is FCC.The first author gratefully acknowledges partial research support from the National Science Foundation, Grant No. 2975010131. The third and fourth authors gratefully acknowledge partial research support from the University of Kansas and the sabbatical leave programs of their respective institutions, and in the case of the fourth author, from the Natural Sciences and Engineering Research Council of Canada.Dow, A.; Porter, JR.; Stephenson, R.; Grant Woods, R. (2004). Spaces whose Pseudocompact Subspaces are Closed Subsets. Applied General Topology. 5(2):243-264. doi:10.4995/agt.2004.1973.2432645

In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization

The manufacture of 3D scaffolds with specific controlled porous architecture, defined microstructure and an adjustable degradation profile was achieved using two-photon polymerization (TPP) with a size of 2  ×  4  ×  2 mm3. Scaffolds made from poly(D,L-lactide-co-ɛ-caprolactone) copolymer with varying lactic acid (LA) and ɛ -caprolactone (CL) ratios (LC16:4, 18:2 and 9:1) were generated via ring-opening-polymerization and photoactivation. The reactivity was quantified using photo-DSC, yielding a double bond conversion ranging from 70% to 90%. The pore sizes for all LC scaffolds were see 300 μm and throat sizes varied from 152 to 177 μm. In vitro degradation was conducted at different temperatures; 37, 50 and 65 °C. Change in compressive properties immersed at 37 °C over time was also measured. Variations in thermal, degradation and mechanical properties of the LC scaffolds were related to the LA/CL ratio. Scaffold LC16:4 showed significantly lower glass transition temperature (T g) (4.8 °C) in comparison with the LC 18:2 and 9:1 (see 32 °C). Rates of mass loss for the LC16:4 scaffolds at all temperatures were significantly lower than that for LC18:2 and 9:1. The degradation activation energies for scaffold materials ranged from 82.7 to 94.9 kJ mol−1. A prediction for degradation time was applied through a correlation between long-term degradation studies at 37 °C and short-term studies at elevated temperatures (50 and 65 °C) using the half-life of mass loss (Time (M1/2)) parameter. However, the initial compressive moduli for LC18:2 and 9:1 scaffolds were 7 to 14 times higher than LC16:4 (see 0.27) which was suggested to be due to its higher CL content (20%). All scaffolds showed a gradual loss in their compressive strength and modulus over time as a result of progressive mass loss over time. The manufacturing process utilized and the scaffolds produced have potential for use in tissue engineering and regenerative medicine applications

Ratios of BB and DD Meson Decay Constants in Relativistic Quark Model

We calculate the ratios of $B$ and $D$ meson decay constants by applying the variational method to the relativistic hamiltonian of the heavy meson. We adopt the Gaussian and hydrogen-type trial wave functions, and use six different potentials of the potential model. We obtain reliable results for the ratios, which are similar for different trial wave functions and different potentials. The obtained ratios show the deviation from the nonrelativistic scaling law, and they are in a pretty good agreement with the results of the Lattice calculations.Comment: 13 pages, 1 Postscript figur

Enhancement of Loop Induced H±W∓Z0H^\pm W^\mp Z^0 Vertex in Two Higgs-doublet Model

The non-decoupling effects of heavy Higgs bosons as well as fermions on the loop-induced $H^\pm W^\mp Z^0$ vertex are discussed in the general two Higgs doublet model. The decay width of the process $H^+ \to W^+ Z^0$ is calculated at one-loop level and the possibility of its enhancement is explored both analytically and numerically. We find that the novel enhancement of the decay width can be realized by the Higgs non-decoupling effects with large mass-splitting between the charged Higgs boson and the CP-odd one. This is due to the large breakdown of the custodial $SU(2)_V$ invariance in the Higgs sector. The branching ratio can amount to $10^{-2} \sim 10^{-1}$ for $m_{H^\pm} = 300$ GeV within the constraint from the present experimental data. Hence this mode may be detectable at LHC or future $e^+e^-$ linear colliders.Comment: 31+1 pages, Latex with 8 eps-file

Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical <i>in vitro</i> tribological study

Osteochondral grafts are used for repair of focal osteochondral lesions. Autologous grafts are the gold standard treatment; however, limited graft availability and donor site morbidity restrict use. Therefore, there is a clinical need for different graft sources/materials which replicate natural cartilage function. Chitosan has been proposed for this application. The aim of this study was to assess the biomechanics and biotribology of a bioresorbable chitosan/chitosan-nano-hydroxyapatite osteochondral construct (OCC), implanted in an in vitro porcine knee experimental simulation model. The OCC implanted in different surgical positions (flush, proud and inverted) was compared to predicate grafts in current clinical use and a positive control consisting of a stainless steel graft implanted proud of the cartilage surface. After 3 h (10 800 cycles) wear simulation under a walking gait, subsidence occurred in all OCC samples irrespective of surgical positioning, but with no apparent loss of material and low meniscus wear. Half the predicate grafts exhibited delamination and scratching of the cartilage surfaces. No graft subsidence occurred in the positive controls but wear and deformation of the meniscus were apparent. Implanting a new chitosan-based OCC either optimally (flush), inverted or proud of the cartilage surface resulted in minimal wear, damage and deformation of the meniscus

Minisuperspace Quantization of "Bubbling AdS" and Free Fermion Droplets

We quantize the space of 1/2 BPS configurations of Type IIB SUGRA found by Lin, Lunin and Maldacena (hep-th/0409174), directly in supergravity. We use the Crnkovic-Witten-Zuckerman covariant quantization method to write down the expression for the symplectic structure on this entire space of solutions. We find the symplectic form explicitly around AdS_5 x S^5 and obtain a U(1) Kac-Moody algebra, in precise agreement with the quantization of a system of N free fermions in a harmonic oscillator potential, as expected from AdS/CFT. As a cross check, we also perform the quantization around AdS_5 x S^5 by another method, using the known spectrum of physical perturbations around this background and find precise agreement with our previous calculation.Comment: 22 Pages + 2 Appendices, JHEP3; v3: explanation of factor 2 mismatch added, references reordered, published versio