Spin correlations in the algebraic spin liquid - implications for high Tc superconductors

We propose that underdoped high $T_c$ superconductors are described by an algebraic spin liquid (ASL) at high energies, which undergoes a spin-charge recombination transition at low energies. The spin correlation in the ASL is calculated via its effective theory - a system of massless Dirac fermions coupled to a U(1) gauge field. We find that without fine tuning any parameters the gauge interaction strongly enhances the staggered spin correlation even in the presence of a large single particle pseudo-gap. This allows us to show that the ASL plus spin-charge recombination picture can explain many highly unusual properties of underdoped high $T_c$ superconductors.Comment: 22 pages, 18 figures, submitted to PR

Staggered flux and stripes in doped antiferromagnets

We have numerically investigated whether or not a mean-field theory of spin textures generate fictitious flux in the doped two dimensional $t-J$-model. First we consider the properties of uniform systems and then we extend the investigation to include models of striped phases where a fictitious flux is generated in the domain wall providing a possible source for lowering the kinetic energy of the holes. We have compared the energetics of uniform systems with stripes directed along the (10)- and (11)-directions of the lattice, finding that phase-separation generically turns out to be energetically favorable. In addition to the numerical calculations, we present topological arguments relating flux and staggered flux to geometric properties of the spin texture. The calculation is based on a projection of the electron operators of the $t-J$ model into a spin texture with spinless fermions.Comment: RevTex, 19 pages including 20 figure

Physical conditions of the interstellar medium of high-redshift, strongly lensed submillimetre galaxies from the Herschel-ATLAS

The definitive version can be found at : http://onlinelibrary.wiley.com/ Copyright Royal Astronomical SocietyWe present Herschel-Spectral and Photometric Imaging Receiver (SPIRE) Fourier transform spectrometer (FTS) and radio follow-up observations of two Herschel-Astrophysical Terahertz Large Area Survey (H-ATLAS)-detected strongly lensed distant galaxies. In one of the targeted galaxies H-ATLAS J090311.6+003906 (SDP. 81), we detect [O III] 88 mu m and [C II] 158 mu m lines at a signal-to-noise ratio of similar to 5. We do not have any positive line identification in the other fainter target H-ATLAS J091305.0-005343 (SDP. 130). Currently, SDP. 81 is the faintest submillimetre galaxy with positive line detections with the FTS, with continuum flux just below 200 mJy in the 200-600 mu m wavelength range. The derived redshift of SDP. 81 from the two detections is z = 3.043 +/- 0.012, in agreement with ground-based CO measurements. This is the first detection by Herschel of the [O III] 88 mu m line in a galaxy at redshift higher than 0.05. Comparing the observed lines and line ratios with a grid of photodissociation region (PDR) models with different physical conditions, we derive the PDR cloud density n approximate to 2000 cm(-3) and the far-ultraviolet ionizing radiation field G(0) approximate to 200 (in units of the Habing field - the local Galactic interstellar radiation field of 1.6 x 10(-6) W m(-2)). Using the CO-derived molecular mass and the PDR properties, we estimate the effective radius of the emitting region to be 500-700 pc. These characteristics are typical for star-forming, high-redshift galaxies. The radio observations indicate that SDP. 81 deviates significantly from the local far-infrared/radio (FIR/radio) correlation, which hints that some fraction of the radio emission is coming from an active galactic nucleus (AGN). The constraints on the source size from millimetre-wave observations put a very conservative upper limit of the possible AGN contribution to less than 33 per cent. These indications, together with the high [OIII]/FIR ratio and the upper limit of [O I] 63 mu m/[C II] 158 mu m, suggest that some fraction of the ionizing radiation is likely to originate from the AGN.Peer reviewe

Interplay of Electron-Phonon Interaction and Electron Correlation in High Temperature Superconductivity

We study the electron-phonon interaction in the strongly correlated superconducting cuprates. Two types of the electron-phonon interactions are introduced in the $t-J$ model; the diagonal and off-diagonal interactions which modify the formation energy of the Zhang-Rice singlet and its transfer integral, respectively. The characteristic phonon-momentum $(\vec q)$ and electron-momentum $(\vec k)$ dependence resulted from the off-diagonal coupling can explain a variety of experiments. The vertex correction for the electron-phonon interaction is formulated in the SU(2) slave-boson theory by taking into account the collective modes in the superconducting ground states. It is shown that the vertex correction enhances the attractive potential for the d-wave paring mediated by phonon with $\vec q=(\pi(1-\delta), 0)$ around $\delta \cong 0.3$ which corresponds to the half-breathing mode of the oxygen motion.Comment: 14 pages, 13 figure

Innovative solutions to novel drug development in mental health

There are many new advances in neuroscience and mental health which should lead to a greater understanding of the neurobiological dysfunction in neuropsychiatric disorders and new developments for early, effective treatments. To do this, a biomarker approach combining genetic, neuroimaging, cognitive and other biological measures is needed. The aim of this article is to highlight novel approaches for pharmacological and non-pharmacological treatment development. This article suggests approaches that can be taken in the future including novel mechanisms with preliminary clinical validation to provide a toolbox for mechanistic studies and also examples of translation and back-translation. The review also emphasizes the need for clinician-scientists to be trained in a novel way in order to equip them with the conceptual and experimental techniques required, and emphasizes the need for private-public partnership and pre-competitive knowledge exchange. This should lead the way for important new holistic treatment developments to improve cognition, functional outcome and well-being of people with neuropsychiatric disorders

Engineered immunogens to elicit antibodies against conserved coronavirus epitopes

Immune responses to SARS-CoV-2 primarily target the receptor binding domain of the spike protein, which continually mutates to escape acquired immunity. Other regions in the spike S2 subunit, such as the stem helix and the segment encompassing residues 815-823 adjacent to the fusion peptide, are highly conserved across sarbecoviruses and are recognized by broadly reactive antibodies, providing hope that vaccines targeting these epitopes could offer protection against both current and emergent viruses. Here we employ computational modeling to design scaffolded immunogens that display the spike 815-823 peptide and the stem helix epitopes without the distracting and immunodominant receptor binding domain. These engineered proteins bind with high affinity and specificity to the mature and germline versions of previously identified broadly protective human antibodies. Epitope scaffolds interact with both sera and isolated monoclonal antibodies with broadly reactivity from individuals with pre-existing SARS-CoV-2 immunity. When used as immunogens, epitope scaffolds elicit sera with broad betacoronavirus reactivity and protect as “boosts” against live virus challenge in mice, illustrating their potential as components of a future pancoronavirus vaccine

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo