A lower bound on the local extragalactic magnetic field

Assuming that the hard gamma-ray emission of Cen A is a result of synchrotron radiation of ultra-relativistic electrons, we derive a lower bound on the local extragalactic magnetic field, $B> 10^{-8}$ G. This result is consistent with (and close to) upper bounds on magnetic fields derived from consideration of cosmic microwave background distortions and Faraday rotation measurements.Comment: Includes extensive discussion of particle acceleration above 10^20 eV in the hot spot-like region of Cen

Level Set Method for the Evolution of Defect and Brane Networks

A theory for studying the dynamic scaling properties of branes and relativistic topological defect networks is presented. The theory, based on a relativistic version of the level set method, well-known in other contexts, possesses self-similar ``scaling'' solutions, for which one can calculate many quantities of interest. Here, the length and area densities of cosmic strings and domain walls are calculated in Minkowski space, and radiation, matter, and curvature-dominated FRW cosmologies with 2 and 3 space dimensions. The scaling exponents agree the naive ones based on dimensional analysis, except for cosmic strings in 3-dimensional Minkowski space, which are predicted to have a logarithmic correction to the naive scaling form. The scaling amplitudes of the length and area densities are a factor of approximately 2 lower than results from numerical simulations of classical field theories. An expression for the length density of strings in the condensed matter literature is corrected.Comment: 46pp LaTeX, revtex4(preprint), 1 eps figure, revised for publication. Note title chang

Association of Immunosuppression and Human Immunodeficiency Virus (HIV) Viremia with Anal Cancer Risk in Persons Living with HIV in the United States and Canada

Background: People living with human immunodeficiency virus (HIV; PLWH) have a markedly elevated anal cancer risk, largely due to loss of immunoregulatory control of oncogenic human papillomavirus infection. To better understand anal cancer development and prevention, we determined whether recent, past, cumulative, or nadir/peak CD4+ T-cell count (CD4) and/or HIV-1 RNA level (HIV RNA) best predict anal cancer risk. Methods: We studied 102 777 PLWH during 1996-2014 from 21 cohorts participating in the North American AIDS Cohort Collaboration on Research and Design. Using demographics-adjusted, cohort-stratified Cox models, we assessed associations between anal cancer risk and various time-updated CD4 and HIV RNA measures, including cumulative and nadir/peak measures during prespecified moving time windows. We compared models using the Akaike information criterion. Results: Cumulative and nadir/peak CD4 or HIV RNA measures from approximately 8.5 to 4.5 years in the past were generally better predictors for anal cancer risk than their corresponding more recent measures. However, the best model included CD4 nadir (ie, the lowest CD4) from approximately 8.5 years to 6 months in the past (hazard ratio [HR] for <50 vs ≥500 cells/μL, 13.4; 95% confidence interval [CI], 3.5-51.0) and proportion of time CD4 <200 cells/μL from approximately 8.5 to 4.5 years in the past (a cumulative measure; HR for 100% vs 0%, 3.1; 95% CI, 1.5-6.6). Conclusions: Our results are consistent with anal cancer promotion by severe, prolonged HIV-induced immunosuppression. Nadir and cumulative CD4 may represent useful markers for identifying PLWH at higher anal cancer risk

Continuum effects in nuclear pairing properties

If we consider the history of science as a whole, we find that the great advances and the great scientific theories until the 18th century were produced by universal minds for whom science was part of a philosophical, humanist, metaphysical and even theological process. This “ontological characteristic” has been questioned since the early 19th century by the necessary specialisation because of technical advances and the emergence of increasingly abstract models and new subjects. We are going to show how this specialisation has cut scientific research and learning from its historical and epistmological roots, and how science has been restricted to models that are misunderstood and to “formulas” that scientists use without any critical eye and without connecting them with the history of concepts. We will use practical examples, and expose the difficulties that science teaching is now facing -particularly as students desert scientific studies- so as to conclude that it is necessary to return to a cultural and cross-disciplinary vision of science. Science should get closer to a new version of universalism than to an excessive specialisation that unfortunately cuts it from its ontological roots