Dinamička simulacija mehaničkih opterećenja – pristup zasnovan na svojstvima industrijskih elektromotornih pogona

Dynamic emulation of mechanical loads presents a modern and interesting approach for testing and validating performance of electrical drives without a real mechanical load included in the test rig. The paper presents an approach to dynamic emulation of mechanical loads when the load torque and inertia mass of emulated load can be significantly greater than that of laboratory test rig. Closed-loop control of load torque and feedforward compensation of inertia and friction torques are used in a test rig. The approach is focused on the use with standard industrial converters. The described method can be used for design and validation of speed control algorithms in mechatronic applications. Experimental results with the emulation of linear loads are presented in end of the paper.Dinamička simulacija mehaničkih opterećenja predstavlja moderan i zanimljiv pristup testiranju i validaciji ponašanja elektromotornih pogona bez uključenog stvarnog mehaničkog opterećenja u eksperimentalni postav. U radu je predstavljen pristup s dinamičkom simulacijom mehaničkih opterećenja za slučaj kada moment tereta ili moment tromosti simuliranog tereta mogu biti daleko veći od onih dostupnih u eksperimentalnom postavu. U postavu se koristi upravljanje momentom tereta u zatvorenoj petlji uz unaprijednu petlju kompenzacije momenta tromosti i momenata trenja. Pristup je usmjeren na upotrebu standardnih industrijskih pretvarača. Opisana metoda može se koristiti za sintezu i validaciju algoritama za upravljanje po brzini u mehatroničkim primjenama. U radu su predstavljeni eksperimentalni rezultati za slučaj simulacije linearnih tereta

The stability inequality for Ricci-flat cones

In this article, we thoroughly investigate the stability inequality for Ricci-flat cones. Perhaps most importantly, we prove that the Ricci-flat cone over CP^2 is stable, showing that the first stable non-flat Ricci-flat cone occurs in the smallest possible dimension. On the other hand, we prove that many other examples of Ricci-flat cones over 4-manifolds are unstable, and that Ricci-flat cones over products of Einstein manifolds and over Kähler-Einstein manifolds with h^{1,1}>1 are unstable in dimension less than 10. As results of independent interest, our computations indicate that the Page metric and the Chen-LeBrun-Weber metric are unstable Ricci shrinkers. As a final bonus, we give plenty of motivations, and partly confirm a conjecture of Tom Ilmanen relating the lambda-functional, the positive mass theorem and the nonuniqueness of Ricci flow with conical initial data

An efficient strategy for evaluating new non-invasive screening tests for colorectal cancer: the guiding principles.

New screening tests for colorectal cancer (CRC) are rapidly emerging. Conducting trials with mortality reduction as the end point supporting their adoption is challenging. We re-examined the principles underlying evaluation of new non-invasive tests in view of technological developments and identification of new biomarkers. A formal consensus approach involving a multidisciplinary expert panel revised eight previously established principles. Twelve newly stated principles emerged. Effectiveness of a new test can be evaluated by comparison with a proven comparator non-invasive test. The faecal immunochemical test is now considered the appropriate comparator, while colonoscopy remains the diagnostic standard. For a new test to be able to meet differing screening goals and regulatory requirements, flexibility to adjust its positivity threshold is desirable. A rigorous and efficient four-phased approach is proposed, commencing with small studies assessing the test's ability to discriminate between CRC and non-cancer states (phase I), followed by prospective estimation of accuracy across the continuum of neoplastic lesions in neoplasia-enriched populations (phase II). If these show promise, a provisional test positivity threshold is set before evaluation in typical screening populations. Phase III prospective studies determine single round intention-to-screen programme outcomes and confirm the test positivity threshold. Phase IV studies involve evaluation over repeated screening rounds with monitoring for missed lesions. Phases III and IV findings will provide the real-world data required to model test impact on CRC mortality and incidence. New non-invasive tests can be efficiently evaluated by a rigorous phased comparative approach, generating data from unbiased populations that inform predictions of their health impact

Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They are significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values < 0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice

Küçülme Stratejisinin Çalişanların Örgüte Bağlılıkları Üzerindeki Etkileri Kayseri İli nde Bir Araştırma

This paper investigates a global search optimisation technique, referred to as the repeated weighted boosting search. The proposed optimisation algorithm is extremely simple and easy to implement. Heuristic explanation is given for the global search capability of this technique. Comparison is made with the two better known and widely used global search techniques, known as the genetic algorithm and adaptive simulated annealing. The effectiveness of the proposed algorithm as a global optimiser is investigated through several examples

Colorectal cancer screening: A global overview of existing programmes

Colorectal cancer (CRC) ranks third among the most commonly diagnosed cancers worldwide, with wide geographical variation in incidence and mortality across the world. Despite proof that screening can decrease CRC incidence and mortality, CRC screening is only offered to a small proportion of the target population worldwide. Throughout the world there are widespread differences in CRC screening implementation status and strategy. Differences can be attributed to geographical variation in CRC incidence, economic resources, healthcare structure and infrastructure to support screening such as the ability to identify the target population at risk and cancer registry availability. This review highlights issues to consider when implementing a CRC screening programme and gives a worldwide overview of CRC burden and the current status of screening programmes, with focus on international differences