115 research outputs found
Extragalactic neutrino background from very young pulsars surrounded by supernova envelopes
We estimate the extragalactic muon neutrino background which is produced by
hadrons injected by very young pulsars at an early phase after supernova
explosion. It is assumed that hadrons are accelerated in the pulsar wind zone
which is filled with thermal photons captured below the expanding supernova
envelope. In collisions with those thermal photons hadrons produce pions which
decay into muon neutrinos. At a later time, muon neutrinos are also produced by
the hadrons in collisions with matter of the expanding envelope. We show that
extragalactic neutrino background predicted by such a model should be
detectable by the planned 1 km neutrino detector if a significant part of
pulsars is born with periods shorter than ms. Since such population
of pulsars is postulated by the recent models of production of extremely high
energy cosmic rays, detection of neutrinos with predicted fluxes can be used as
their observational test.Comment: 4 pages, 2 figures, A&A style, accepted to A&A Let
Observations of metals in the intra-cluster medium
Because of their deep gravitational potential wells, clusters of galaxies
retain all the metals produced by the stellar populations of the member
galaxies. Most of these metals reside in the hot plasma which dominates the
baryon content of clusters. This makes them excellent laboratories for the
study of the nucleosynthesis and chemical enrichment history of the Universe.
Here we review the history, current possibilities and limitations of the
abundance studies, and the present observational status of X-ray measurements
of the chemical composition of the intra-cluster medium. We summarise the
latest progress in using the abundance patterns in clusters to put constraints
on theoretical models of supernovae and we show how cluster abundances provide
new insights into the star-formation history of the Universe.Comment: 28 pages, 12 figures, accepted for publication in Space Science
Reviews, special issue "Clusters of galaxies: beyond the thermal view",
Editor J.S. Kaastra, Chapter 16; work done by an international team at the
International Space Science Institute (ISSI), Bern, organised by J.S.
Kaastra, A.M. Bykov, S. Schindler & J.A.M. Bleeke
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures
Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo
B77 impact test data processing
With the system of equations presented, variables which describe the motion of B77 Impact Test Units can be obtained from high-speed motion picture data. Equations are developed that describe the kinematics of the body in terms of linear and angular positions, velocities and acceleration, flight path azimuth and elevation angles, and total angle of attack and windward meridian angle. The dynamics of the body are described in terms of its linear and angular momentum, its kinetic and potential energies, and the external forces and moments
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Practical applications of adaptive mesh refinement (rezoning)
A collection of finite element problems that have been examined with a posteriori convergence measures is presented. Results show that these local convergence measures can be used to indicate the quality of a finite element solution and to suggest boundaries for mesh rezones. 18 figures, 1 table
Entanglement, evaluation and practice in a professional learning innovation
Evaluations of professional development programmes often seek to represent definitive outcomes, with phenomena posited as discrete, bounded and independent entities, and researchers positioned as external actors. An alternative is to understand the complexity of these relationships as entanglements by applying Baradian concepts. The value of this is illustrated through the example of the evaluation of the Mathematics Teacher Exchange (MTE). The MTE is a transnational professional learning programme, part of a policy described as learning from East-Asian mathematics teaching to introduce ‘teaching for mastery’ in England. Four instances of entanglement are analysed. The first two of these relate to the entanglement of evaluation processes and the mastery innovation in knowledge production. The other two examples are entanglements and diffractions that are found in changes in pedagogical practice related to mathematics representations and ways learners are grouped in classrooms. Although the transnational nature of the MTE is unusual and specific to the current English context, similar entanglements may be found in more locally generated teacher change initiatives and in their evaluation. Thinking in terms of entanglements adds another conceptual tool for sociomaterial and related analysis and also draws attention to our ethical responsibility for these relationalities
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